1012-P: Study of Insulin Stability Impact on Pump Therapy: Test Model Development

This research is a development research that develops teaching materials physics based contextual by integrating local wisdom. To further this research as the basis for the development of textbook physics of high economic value. This study intends to improve the mastery of concepts of physics students. Teaching materials developed using models of R & D with develop model used is a model development Borg & Gall (1985) and Kemp and Dayton (1985), which consists of; (1) research and data collection through surveys, (2) planning, (3) the preparation of teaching materials printed in the form of student worksheets, (4) test the validity of the expert, (5) product revision, (6) field trials small scale, (7) the revised product, (8) broad-scale field trials, (9) the revision of the final product, and (10) the dissemination and implementation. The trials conducted teaching materials student of physics education by test model one group pretest-posttes design. And based on the analysis of the data validation and testing that the teaching materials developed showing the criteria of "very feasible" to use and to improve the procurement of the concepts of physics students in basic physics lectures. Penelitian ini adalah penelitian pengembangan yang mengembangkan bahan ajar fisika berbasis kontekstual dengan mengintegrasikan kearifan lokal. Untuk lebih jauh penelitian ini sebagai dasar pengembangan buku ajar Fisika yang bernilai ekonomi tinggi. Penelitian ini bermaksud untuk meningkatkan pemahaman konsep fisika peserta didik. Bahan ajar dikembangkan menggunakan model R & D dengan model pengembangan yang digunakan adalah model Borg & Gall (1989) dan Kemp & Dayton (1985) yang terdiri atas; (1) penelitian dan pengumpulan data melalui survei, (2) perencanaan, (3) penyusunan bahan ajar cetak dalam bentuk lembar kerja siswa, (4) uji validitas pakar, (5) revisi produk, (6) uji coba lapangan skala kecil, (7) revisi produk, (8) uji coba lapangan skala luas, (9) revisi produk final, dan (10) diseminasi dan implementasi. Uji coba bahan ajar dilakukan mahasiswa program studi pendidikan fisika dengan model tes one group pretest-posttes design. Dan berdasarkan hasil analisis dari data validasi dan uji coba bahwa bahan ajar yang dikembangkan menunjukkan kriteria”sangat layak” untuk digunakan serta dapat meningkatkan pemahaman konsep fisika mahasiswa pada perkuliahan fisika dasar.

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PENDIDIKAN MULTIKULTURAL MELALUI PROGRAM BAHASA HOLISTIK (PENELITIAN PENGEMBANGAN DI KELOMPOK B TAMAN KANAK-KANAK NASIMA SEMARANG)

JPUD - Jurnal Pendidikan Usia Dini ◽

10.21009/jpud.112.09 ◽

2017 ◽

Vol 11 (2) ◽

pp. 308-322

Author(s):

ROOSTRIANAWAHTI SOEKMONO

Keyword(s):

Multicultural Education ◽

Whole Language ◽

Learning Strategy ◽

Model Development ◽

Social Background ◽

Test Model ◽

Diversity Awareness ◽

Validation Test ◽

Preliminary Study ◽

Development Approach

Abstract: A challenging diversity in Indonesian society turns out to be cultural asset and conflict.Tolerance is the main key to ease up the cultural conflict through multicultural education. Earlychildhood can be taught about diversity awareness by diversity experience, which is a basic stepdevelopment of tolerance. This study is aimed to uncover learning strategy in enhancing diversityawareness, such as, understanding diversity, skill in communicating diversity and treatingdiversity positively. This study employs Research and Development approach modified into threephases of research: preliminary study, development model and validation test model. In thepreliminary study, bibliographical study discusses multicultural theme “What a BeautifulDiversity in the Old Town” and social background study about children culture in Semarang city.Development model consist of five steps based on five concepts, namely, identification ofmulticultural theme, unit planning of multicultural theme with whole language programme,preparation for game apparatus and books about multicultural stories, implementation ofmulticultural learning, and assesment on diversity awareness. Validation test model is comprisedof assesment validation about diversity awareness and models of validation by experts. It’ssignificant, effective and appropriate. Discoveries resulting from study, communication andparticipation are factors influencing level of diversity awareness. Keywords: Model Development, Multicultural Education, Whole Language Programme andDiversity awareness Abstrak: Masyarakat Indonesia yang beragam merupakan tantangan, menjadi modal budaya ataukonflik budaya. Konflik budaya dapat dikurangi dengan mengembangkan sikap toleran melaluipendidikan multikultural. Pada anak usia dini kita dapat meningkatkan kesadaran tentangkeberagaman, yang merupakan dasar dari sikap toleran. Penelitian ini diperlukan untukmenemukan strategi pembelajaran untuk meningkatkan kesadaran tentang keberagaman, sepertimemahami, mengkomunikasikan dan menyikapi keberagaman dengan cara positif. Pendekatanpenelitian menggunakan Penelitian dan Pengembangan yang dimodifikasi dalam tiga langkahpenelitian yaitu: studi pendahuluan, model pengembangan dan model tes validasi. Studipendahuluan berisi studi pustaka untuk tema multikultural “Indahnya keberagaman kota lama” danstudi latar belakang sosial budaya anak. Model pengembangan mempunyai lima langkah yangdikembangkan dari lima konsep yaitu identifikasi tema multikultural, perencanaan unit dari temamultikultural dengan program bahasa holistik, Persiapan alat permainan dan buku ceritamultikultural, implementasi pembelajaran multikultural, dan asesmen kesadaran tentangkeberagaman. Model tes validasi berupa validasi asesmen kesadaran tentang keberagaman danvalidasi model oleh pakar. Asesmen kesadaran tentang keberagaman dalam uji coba kelompokkecil adalah signifikan, model terbukti efektif meningkatkan kesadaran tentang keberagaman.Pakar menyatakan model layak. Temuan penelitian komunikasi dan partisipasi adalah faktor yangberpengaruh untuk meningkatkan kesadaran tentang keberagaman. Komunikasi dan partisipasipada usia dini dipengaruhi oleh budaya suku dan suku mayoritas. Kata Kunci: Pengembangan Model, Pendidikan Multikultural, Program Whole Language danKeanekaragaman

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Evaluation of JULES-crop performance against site observations of irrigated maize from Mead, Nebraska

10.5194/gmd-2016-252 ◽

2016 ◽

Author(s):

Karina Williams ◽

Jemma Gornall ◽

Anna Harper ◽

Andy Wiltshire ◽

Debbie Hemming ◽

...

Keyword(s):

Input Parameter ◽

Model Development ◽

Crop Productivity ◽

Crop Model ◽

Test Model ◽

Area Index ◽

Crop Varieties ◽

Weather And Climate ◽

Set Up ◽

The Impact

Abstract. The JULES-crop model (Osborne et al., 2015) is a parameterisation of crops within the Joint UK Land Environment Simulator (JULES), which aims to simulate both the impact of weather and climate on crop productivity and the impact of crop-lands on weather and climate. In this evaluation paper, observations of maize at three FLUXNET sites in Nebraska (US-Ne1, US-Ne2, US-Ne3) are used to test model assumptions and make appropriate input parameter choices. JULES runs are performed for the irrigated sites (US-Ne1 and US-Ne2) both with the crop model switched off (prescribing leaf area index (LAI) and canopy height) and with the crop model switched on. These are compared against GPP and carbon pool FLUXNET observations. We use the results to point to future priorities for model development and describe how our methodology can be adapted to set up model runs for other sites and crop varieties. The implications of our results on the choice of parameters and settings to be used in global runs of JULES-crop are also discussed.

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Evaluation of JULES-crop performance against site observations of irrigated maize from Mead, Nebraska

Geoscientific Model Development ◽

10.5194/gmd-10-1291-2017 ◽

2017 ◽

Vol 10 (3) ◽

pp. 1291-1320 ◽

Cited By ~ 9

Author(s):

Karina Williams ◽

Jemma Gornall ◽

Anna Harper ◽

Andy Wiltshire ◽

Debbie Hemming ◽

...

Keyword(s):

Input Parameter ◽

Model Development ◽

Crop Productivity ◽

Crop Model ◽

Test Model ◽

Area Index ◽

Crop Varieties ◽

Weather And Climate ◽

Set Up ◽

The Impact

Abstract. The JULES-crop model (Osborne et al., 2015) is a parametrisation of crops within the Joint UK Land Environment Simulator (JULES), which aims to simulate both the impact of weather and climate on crop productivity and the impact of croplands on weather and climate. In this evaluation paper, observations of maize at three FLUXNET sites in Nebraska (US-Ne1, US-Ne2 and US-Ne3) are used to test model assumptions and make appropriate input parameter choices. JULES runs are performed for the irrigated sites (US-Ne1 and US-Ne2) both with the crop model switched off (prescribing leaf area index (LAI) and canopy height) and with the crop model switched on. These are compared against GPP and carbon pool FLUXNET observations. We use the results to point to future priorities for model development and describe how our methodology can be adapted to set up model runs for other sites and crop varieties.

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A Study on the Test Model Development for Design Creativity Evaluation and Its Application

A Journal of Brand Design Association of Korea ◽

10.18852/bdak.2018.16.2.117 ◽

2018 ◽

Vol 16 (2) ◽

pp. 117-134 ◽

Cited By ~ 1

Author(s):

송영은

Keyword(s):

Model Development ◽

Test Model ◽

Design Creativity

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Population pharmacokinetics (Pop PK) of MYL-1402O (a proposed biosimilar to bevacizumab) and reference product (Avastin) in patients with nonsquamous non-small cell lung cancer (nsNSCLC).

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e21087 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e21087-e21087

Author(s):

Joel Owen ◽

Russell J. Rackley ◽

Matthew A. Hummel ◽

Stefan Roepcke ◽

Hannah Huang ◽

...

Keyword(s):

Reference Product ◽

Phase 1 ◽

Model Development ◽

Stage Iv ◽

Parameter Estimates ◽

Model Parameters ◽

Test Model ◽

Phase 3 ◽

Double Blind ◽

Model Based

e21087 Background: MYL-1402O (MYL) is a proposed biosimilar to bevacizumab reference product. A multicenter, double blind randomized, phase 3 study compared the efficacy, safety, PK, and immunogenicity of MYL and Avastin in patients with Stage IV metastatic nsNSCLC. Patients received either MYL or reference product, in combination with carboplatin-paclitaxel up to 18 weeks (6 cycles) followed by monotherapy for up to an additional 24 weeks (8 cycles). The objective was to develop a Pop PK model based on data from a phase 3 study pooled with a single dose healthy volunteer phase 1 study data; to assess PK linearity across the dose levels of 1 mg/kg to 15 mg/kg in 2 clinical studies; to assess the PK similarity of MYL and reference product in patients with nsNSCLC; and to explore potential covariates to account for variability in Pop PK model parameters. Methods: A Pop PK model was developed based on preliminary analyses of MYL phase 1 data and published population analyses of reference product using a 2-compartment linear model (Han K et al., 2016). Individual empiric Bayesian parameter estimates of nsNSCLC patients were used to predict PK measures reflecting exposure to drug and were compared qualitatively between treatments. Results: The data subset used for model development consisted of 8724 records from 771 subjects. Population PK analyses indicated no differences between PK profiles of patients in the MYL and reference product arms. Importantly, treatment was not a significant covariate of clearance ( P = 0.453) or volume of the central compartment ( P = 0.161) using the likelihood ratio χ2 test. Model-based steady state exposure measures, predicted based on the final model for all patients, were also similar between treatment arms (Table). Conclusions: The model supported linear PK at clinical doses in patients with nsNSCLC; there were no clinically relevant/significant differences between the PK of MYL and reference product; and the findings were consistent with the PK study in normal, healthy volunteers. Bayesian Parameter Clinical trial information: 2015-005141-32. [Table: see text]

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