1471-P: Efficacy of Lifestyle Intervention in Preventing Diabetes in People with IGT with and without Impaired Fasting Glucose: A Secondary Analysis of Da Qing Diabetes Prevention Outcomes Study (DQDPOS)

It is well established that individuals who have prediabetes either impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) have high risk to develop diabetes. However, it is unclear whether the rate of progression to diabetes is different between these two categories. Lifestyle modification has been recommended for diabetes prevention in these high-risk groups. However, given the differences in their pathophysiology, it is possible that these subtypes of prediabetes condition may have different responses to lifestyle modification. The present review was to summarize the risk of progression to diabetes and the effectiveness of lifestyle intervention for diabetes prevention in individuals who have isolated IGT or isolated IFG or combined. The risk of progression to diabetes is highest in combined IFG and IGT subtype. Individuals who have isolated IFG by the American Diabetes Association criteria (100 to 125 mg/dl) has lower risk of progression to diabetes than those with World Health Organization criteria (110 to 125 mg/dl) and the latter has similar or higher risk of incident diabetes than those with isolated IGT. Lifestyle modification is most effective in individuals with IGT (with or without IFG) but is less effective in those with isolated IFG. In conclusion, The risk of progression to diabetes and the effectiveness of lifestyle intervention for diabetes prevention are disparate between prediabetes subtypes. Given the paucity of diabetes prevention data in individuals with isolated IFG, more studies dedicated to this subtype is required. Keywords: Impaired fasting glucose, Impaired glucose tolerance, Prediabetes, Type 2 diabetes, Lifestyle intervention, Diabetes prevention

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Predictors of Sustained Reduction in Energy and Fat Intake in the Diabetes Prevention Program Outcomes Study Intensive Lifestyle Intervention

Journal of the Academy of Nutrition and Dietetics ◽

10.1016/j.jand.2013.07.003 ◽

2013 ◽

Vol 113 (11) ◽

pp. 1455-1464 ◽

Cited By ~ 14

Author(s):

Nichola J. Davis ◽

Yong Ma ◽

Linda M. Delahanty ◽

Heather J. Hoffman ◽

Elizabeth Mayer-Davis ◽

...

Keyword(s):

Lifestyle Intervention ◽

Prevention Program ◽

Diabetes Prevention ◽

Diabetes Prevention Program ◽

Fat Intake ◽

Program Outcomes ◽

Intensive Lifestyle Intervention ◽

Sustained Reduction ◽

Outcomes Study

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STUDI LITERATUR EFEK MODIFIKASI GAYA HIDUP SECARA INTENSIF PADA PREDIABETES

JURNAL ILMU KEDOKTERAN DAN KESEHATAN ◽

10.33024/jikk.v7i4.3211 ◽

2020 ◽

Vol 7 (4) ◽

Author(s):

Serra Meilawati

Keyword(s):

Diabetes Mellitus ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Impaired Fasting Glucose ◽

Prevention Program ◽

Diabetes Prevention ◽

Fasting Glucose ◽

Diabetes Prevention Program ◽

Prevention Study ◽

Diabetes Prevention Study

Prediabetes adalah kondisi sebelum terjadinya diabetes mellitus tipe 2. Impaired Fasting Glucose (IFG) dan Impaired Glucose Tolerance (IGT) merupakan kondisi prediabetes. Prevalensi diabetes mellitus tipe 2 yang terus meningkat disebabkan karena setiap tahunnya 4-9% orang dengan prediabetes akan berkembang menjadi diabetes. IGT mempunyai risiko lebih tinggi untuk berkembang menjadi diabetes mellitus tipe 2. Sehingga upaya pencegahan agar tidak berkembangnya prediabetes menjadi diabetes mellitus tipe 2 menjadi sangat penting. Modifikasi gaya hidup secara intensif merupakan upaya yang dapat dilakukan pada prediabetes. Diabetes Prevention Program (DPP) di Amerika Serikat dan Finnish Diabetes Prevention Study (DPS) melakukan uji klinis yang menunjukkan bahwa modifikasi gaya hidup efektif dalam mengurangi atau menunda onset diabetes mellitus tipe 2 sebesar 4058% pada individu yang mempunyai risiko tinggi. Adapun modifikasi gaya hidup yang dapat dilakukan seperti, penurunan berat badan pada prediabetes dianjurkan sebesar 5-10% dari berat badan awal, perubahan pola makan dengan mengurangi konsumsi karbohidrat sederhana dan memperbanyak konsumsi serat, dan aktivitas fisik dilakukan selama 30-60 menit setiap hari. Modifikasi gaya hidup secara intensif pada prediabetes mempunyai efektivitas yang bagus.

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