OBJECTIVE: To conduct <i>post-hoc</i>
secondary analysis examining the association between change in physical
activity (PA), measured with self-report and accelerometry, from baseline to 1
and 4 years and cardiovascular disease (CVD) outcomes in the Look AHEAD Trial.
<p>RESEARCH DESIGN AND METHODS: Participants were adults with overweight/obesity
and type 2 diabetes with PA data at baseline and year 1 or 4 (n = 1,978). Participants
were randomized to diabetes support and education or intensive lifestyle
intervention. Measures included accelerometry-measured moderate-to-vigorous PA
(MVPA), self-reported PA, and composite (morbidity and mortality) CVD outcomes.</p>
<p>RESULTS: In pooled analyses of all participants, using Cox
proportional hazards models, each 100 MET-min/wk increase in accelerometry-measured
MVPA from baseline to 4 years was associated with decreased risk of the subsequent
primary composite outcome of CVD. Results were consistent for changes in total MVPA
[HR=0.97 (95% CI: 0.95, 0.99)] and MVPA accumulated in <u>></u>10-minute
bouts [HR=0.95 (95% CI: 0.91, 0.98)], with a similar pattern for secondary CVD
outcomes. Change in accelerometry-measured MVPA at 1 year and self-reported
change in PA at 1 and 4 years were not associated with CVD outcomes.</p>
<p>CONCLUSIONS: Increased accelerometry-measured MVPA from
baseline to year 4 is associated with decreased risk of CVD outcomes. This
suggests the need for long-term engagement in MVPA to reduce the risk of CVD in
adults with overweight/obesity and type 2 diabetes.</p>
Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial
