The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Nondiabetic Adults: Response to Tournis and Mitrakou

BACKGROUND It has been shown that many women with polycystic ovary syndrome (PCOS) are 25-hydroxyvitamin D (25OHD) insufficient. Both statin treatment and vitamin D supplementation have been shown to improve biochemical hyperandrogenemia, insulin resistance, and markers of inflammation in patients with PCOS, raising the possibility that some of the statin effects are mediated through vitamin D. METHODS We conducted this randomized, double-blind placebo controlled study to assess the effect of atorvastatin on serum 25OHD concentrations in patients with PCOS. Forty medication-naive patients with PCOS were randomized to either atorvastatin 20 mg daily or placebo for 3 months. After completing the initial 3 months of atorvastatin or placebo, both groups of patients participated in a 3-month extension study with metformin 1500 mg daily. We measured changes in 25OHD concentrations by use of tandem mass spectrometry. RESULTS Mean (SD) baseline 25OHD concentrations were comparable between the 2 groups [45.9 (2.4) vs 44.8 (1.8) nmol/L; P = 0.7]. There was a significant increase in 25OHD concentrations with atorvastatin [45.9 (2.4) vs 60.8 (3.5) nmol/L] compared with placebo [44.8 (1.8) vs 41.8 (3.2) nmol/L; P = 0.02]. Three-month treatment with metformin maintained the improvement of 25OHD with atorvastatin compared to baseline [45.9 (2.4) vs 61.8 (3.5), P ≤ 0.01). There were no significant changes in 25OHD concentrations in the placebo group after 12 weeks of metformin. CONCLUSIONS Among patients with polycystic ovary syndrome, 12 weeks of atorvastatin led to a clinically significant rise in 25OHD concentrations. This may represent a beneficial pleiotropic effect of statins on 25OHD concentrations.

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LSC Abstract – Effects of vitamin D supplementation on perioperative markers of inflammation in patients at risk of acute respiratory distress syndrome (ARDS)

10.1183/13993003.congress-2016.oa466 ◽

2016 ◽

Author(s):

Rachel Dancer ◽

Dhruv Parekh ◽

David Thickett

Keyword(s):

At Risk ◽

Vitamin D ◽

Acute Respiratory Distress Syndrome ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Vitamin D Supplementation ◽

Markers Of Inflammation ◽

Patients At Risk

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Vitamin D supplementation improves waist-to-hip ratio and fasting blood glucose in vitamin D deficient, overweight or obese Asians: A pilot secondary analysis of a randomised controlled trial

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2018.10.006 ◽

2019 ◽

Vol 186 ◽

pp. 136-141 ◽

Cited By ~ 1

Author(s):

David Scott ◽

Aya Mousa ◽

Negar Naderpoor ◽

Maximilian P.J. de Courten ◽

Robert Scragg ◽

...

Keyword(s):

Vitamin D ◽

Blood Glucose ◽

Randomised Controlled Trial ◽

Controlled Trial ◽

Fasting Blood Glucose ◽

Secondary Analysis ◽

Vitamin D Supplementation ◽

Waist To Hip Ratio ◽

Randomised Controlled

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Effect of Vitamin D Supplementation on Insulin, Fasting Blood Glucose, and Waist-Hip Ratio in Young Females with Pre-existing Vitamin D Deficiency

The Indonesian Biomedical Journal ◽

10.18585/inabj.v11i1.489 ◽

2019 ◽

Vol 11 (1) ◽

pp. 42-7

Author(s):

Mona Hmoud AlSheikh ◽

Shayma Ibrahim Almubayadh

Keyword(s):

Vitamin D ◽

Placebo Group ◽

Blood Glucose ◽

Vitamin D Deficiency ◽

Fasting Blood Glucose ◽

Insulin Level ◽

Vitamin D Supplementation ◽

Small Sample ◽

Young Females ◽

Waist Hip Ratio

BACKGROUND: Vitamin D is an essential nutrient requirement for adults and children for normal metabolism and maintenance of healthy bones. Its deficiency may disrupt homeostasis and contribute to systemic diseases, especially in obese patients. This study aimed to examine the effect of vitamin D on insulin, fasting blood glucose (FBG) and waist-hip ratio (WHR) in young and obese Saudi females with pre-existing hypovitaminosis D.METHODS: The results of this study were based on prospective parallel randomised controlled clinical trial conducted at King Fahd University Hospital in which 30 obese Saudi young females aging 18-23 years with preexisting vitamin D deficiency contributed. Participants were randomly assigned to either vitamin D supplementation group (experimental) or placebo group (control). Subjects of vitamin D group received 50,000 IU/week of cholecalciferol drops and placebo group received 10 mL of normal saline drops for 12 weeks.RESULTS: The results of multivariate repeated measures analysis showed a change in serum 25-Hydroxycholecalciferol levels after vitamin D supplementation (F=296.132, p<0.05). There was also an indication of difference between the vitamin D group and placebo group. The only significant relationship was found between vitamin D and FBG (p<0.05). Supplementation of vitamin D improved FBG but did not contribute to improving insulin level. There was no association between vitamin D supplementation and WHR.CONCLUSION: This study concludes that supplementation of vitamin D improves FBG, but it has no contribution in improving insulin level. No association exists between vitamin D supplementation and WHR. The insignificant correlation of vitamin D intake with WHR and insulin can be attributed to the small sample size, therefore, further research is suggested with large sample size.KEYWORDS: vitamin D, fasting blood glucose, body mass index, waist hip ratio, hypovitaminosis D

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