Effect of Vitamin D Supplementation on Blood Glucose Homeostasis, BMI and Lipid Profile in Diabetic Patients with Vitamin D Deficiency

Background: Dyslipidemia is one of the most common metabolic syndrome among diabetic patients due to several factors include insulin insufficiency, resistance, and central obesity. Furthermore both vitamin D deficiency and diabetes are most public health worldwide problems. Therefore the aim of the present work to study the dyslipidemia and vitamin D status in diabetes patients and also to study the relation between vitamin D status and lipid profile in diabetic patients. Methods: A Cross sectional study conducted on randomly selected diabetic patients whether have vitamin D deficiency with dyslipidemia, vitamin D deficiency with no dyslipidemia or dyslipidemia with no vitamin D deficiency. A total sample 165 patients enrolled in the study with serum lipid profile, vitamin D and glycemic control measured at beginning and end of the study. The data analysis was done through Chi-square or T test at α< 0.05. Result: The data collected on 165 patients revealed that, patients aged 41-60 years were most common, and female gender was twice as male. This study include both types of diabetes with vitamin D deficiency and dyslipidemia or vitamin D deficiency with no dyslipidemia or dyslipidemia with not vitamin D deficiency as control. Therefore, the result of this work confirmed that vitamin D deficiency significant implicated in elevated serum levels of TG, TC, LDL, VLDL, FPG and HbA1C (P< 0.05). However, vitamin D deficiency has linked to slight increased serum HDL levels. In compared to man, vitamin D deficiency linked significantly to dyslipidemia and abnormal high levels blood glucose and HbA1C par in women. Conclusion: The present study revealed that, vitamin D deficiency associated negatively with serum levels of TC, TG, VLDL, LDL, FPG and HbA1C whereas the deficiency of vitamin D linked to elevated HDL levels. In gender distribution lower vitamin D values associated with elevated serum FPG, HbA1C, lipid profile with exception HDL in women. The data of this study suggested that, diabetic patients with dyslipidemia may improve their lipid profile and glucose hemostasis through vitamin D supplementation

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The impact of vitamin D supplementation on peripheral neuropathy in a sample of Egyptian prediabetic individuals

F1000Research ◽

10.12688/f1000research.55221.1 ◽

2021 ◽

Vol 10 ◽

pp. 817

Author(s):

Mohamed Reda Halawa ◽

Iman Zaky Ahmed ◽

Nahla Fawzy Abouelezz ◽

Nagwa Roushdy Mohamed ◽

Naira Hany Abdelaziz Khalil ◽

...

Keyword(s):

Vitamin D ◽

Peripheral Neuropathy ◽

Lipid Profile ◽

Vitamin D Deficiency ◽

Short Form ◽

Vitamin D Supplementation ◽

Mcgill Pain Questionnaire ◽

Diabetic Patients ◽

Group A ◽

The Impact

Background: Vitamin D deficiency is seen more frequently in diabetic patients with distal symmetrical polyneuropathy. Unfortunately, there is a shortage of data concerning prediabetic individuals with peripheral neuropathy (PN). Therefore, we aimed to study the association of vitamin D deficiency with PN severity and to determine the effect of vitamin D supplementation on PN in prediabetics. Methods: A case-control study was conducted consisting of 178 prediabetic individuals recruited from the outpatient department of the National Institute of Diabetes and Endocrinology, Cairo, Egypt. All patients were screened for PN using clinical examination and Douleur Neuropathique 4 diagnostic questionnaire (DN4). They were divided into 89 patients with and 89 patients without PN (group A and B). Group A was assessed for neuropathic severity using the Short-Form McGill Pain Questionnaire (SF-MPQ). In addition, 25-hydroxyvitamin D, ionized calcium, phosphorus, parathyroid hormone (PTH), glycated hemoglobin (HbA1c), fasting blood glucose (FBG), 2-hour post 75g glucose (2h-75g glucose) and lipid profile were measured. Prediabetic patients with PN were given vitamin D3 200.000 IU IM monthly for three months. After three months, clinical assessment, DN4, SF-MPQ and all laboratory measures were repeated. Results: Vitamin D level was negatively correlated with neuropathy score and severity (r = -0.65, -0.47, p <0.001) among group A. Moreover, vitamin D level was an independent predictor of neuropathic severity (odds ratio -0.18, 95% CI -0.33 -0.03, P ≤ 0.05). Supplementation of vitamin D resulted in a highly significant improvement in glycemic parameters and lipid profile, p ≤ 0.001. Interestingly, neuropathy score and severity before vitamin D supplementation were (6.4 ± 1.6 and 28.3 ± 7.2) and after became (2.5 ± 0.9 and 17 ± 6.3, p ≤ 0.001). Conclusion: Vitamin D deficiency is an independent risk factor for PN. Correction of vitamin D deficiency improves glycemic parameters, PN score and severity.

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Effect of high-dose vitamin D supplementation in combination with weight loss diet on glucose homeostasis, insulin resistance, and matrix metalloproteinases in obese subjects with vitamin D deficiency: a double-blind, placebo-controlled, randomized clinical trial

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2018-0773 ◽

2020 ◽

Vol 45 (10) ◽

pp. 1092-1098

Author(s):

Soodabeh Aliashrafi ◽

Mehrangiz Ebrahimi-Mameghani ◽

Mohammad Asghari Jafarabadi ◽

Lida Lotfi-Dizaji ◽

Elnaz Vaghef-Mehrabany ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Weight Loss ◽

Matrix Metalloproteinases ◽

Vitamin D Deficiency ◽

Glucose Homeostasis ◽

Vitamin D Supplementation ◽

High Dose ◽

Model Assessment ◽

Obese Subjects

As there is limited and inconsistent evidence in potential role of vitamin D on insulin resistance and matrix metalloproteinases, this study aimed to examine the effect of vitamin D supplementation on glucose homeostasis, insulin resistance, and matrix metalloproteinases in obese subjects with vitamin D deficiency. A total of 44 participants with serum 25-hydroxyvitamin D (25(OH)D) level ≤ 50 nmol/L and body mass index (BMI) 30–40 kg/m2 were randomly allocated into receiving weight reduction diet with either 50 000 IU vitamin D3 pearl (n = 22) or placebo (n = 22) once weekly for 12 weeks. Primary outcomes were changes in fasting serum glucose (FSG), homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and matrix metalloproteinases (MMPs). Secondary outcomes were changes in weight, BMI, 25(OH)D, calcium, phosphorous and parathyroid hormone (PTH). Sun exposure and dietary intakes were also assessed. Serum levels of 25(OH)D3 increased significantly with a simultaneous decrease in serum concentration of PTH in the vitamin D group. Weight, BMI, FSG, and MMP-9 decreased significantly in both groups, and there were significant differences in changes in weight, serum 25(OH)D3, PTH, and MMP-9 levels between the groups. Within- and between-groups analysis revealed no significant differences in serum calcium, phosphorous, serum insulin, HOMA-IR, QUICKI, and MMP-2 after intervention. Our results indicated that improvement in vitamin D status resulted in greater reductions in weight and MMP-9 during weight loss. These preliminary results are sufficient to warrant a bigger study group.

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Effects on lipid profile of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018815599874 ◽

2015 ◽

Vol 6 (6) ◽

pp. 245-248 ◽

Cited By ~ 7

Author(s):

José Manuel Ramiro-Lozano ◽

José María Calvo-Romero

Keyword(s):

Vitamin D ◽

Lipid Profile ◽

Vitamin D Deficiency ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

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Effect of Vitamin D supplementation on vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency

Indian Journal of Endocrinology and Metabolism ◽

10.4103/ijem.ijem_140_17 ◽

2017 ◽

Vol 21 (4) ◽

pp. 555 ◽

Cited By ~ 9

Author(s):

Sandhiya Selvarajan ◽

Nishanthi Anandabaskar ◽

StevenAibor Dkhar ◽

SadishKumar Kamalanathan ◽

Kadhiravan Tamilarasu ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D Supplementation ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

And Oxidative Stress ◽

Type 2 Diabetic

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VITAMIN D STATUS IN A HEALTHY TUNISIAN POPULATION

Journal of Medical Biochemistry ◽

10.5937/jomb0-30247 ◽

2022 ◽

Author(s):

Asma KRIR ◽

Afef BAHLOUS ◽

Mehdi MRAD ◽

BOUKSILA Mouna ◽

KALAI Safa ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Rural Areas ◽

Hypovitaminosis D ◽

Vitamin D Supplementation ◽

Tunisian Population ◽

Diabetic Patients ◽

Dietary Intakes ◽

Vitamin D Status ◽

Vitamin D Levels

Vitamin D deficiency is one of the most common medical conditions worldwide. In Tunisia, several studies evaluated Vitamin D status, but this was concerning specific populations (pregnant women, obese or diabetic patients and children with asthma). The only study that evaluated Vitamin D status in a healthy Tunisian population was conducted by Meddeb and al. in 2002. The update of data available, based on the currently recommended limits, is necessary. This study aimed to estimate the prevalence of hypovitaminosis D in a healthy Tunisian population, and correlate the values with potential risk factors. It was conducted on 209 Tunisian healthy subjects. Data collected included clinical characteristics and dietary intakes. We measured 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), glycemia, creatinine, calcium, phosphorus, proteins and alkaline phosphatase levels. Hypovitaminosis D was retained for 25(OH)D concentrations <30ng/ml. Vitamin D deficiency was defined by 25(OH)D concentrations <10 ng/ml. The prevalence of hypovitaminosis D and vitamin D deficiency were respectively 92.3% and 47.6%. The main factors that were significantly associated with low vitamin D levels in our multivariate analysis were veiling, living in rural areas and sunscreen use. However, sex, age, socioeconomic level, phototype, solar exposure score, smoking and bone mass index, were not statistically associated with hypovitaminosis D. The study of relationship between vitamin D status and serum PTH levels showed a significative and negative correlation (p< 0.005). Given the high prevalence of vitamin D, an adapted health policy is essential. A widespread vitamin D supplementation and food fortification seems to be necessary in Tunisia.

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Prevalence and severity of vitamin D deficiency in patients with diabetic foot infection

British Journal Of Nutrition ◽

10.1017/s0007114512000578 ◽

2012 ◽

Vol 109 (1) ◽

pp. 99-102 ◽

Cited By ~ 27

Author(s):

Shalbha Tiwari ◽

Daliparthy D. Pratyush ◽

Balram Gupta ◽

Awanindra Dwivedi ◽

Sandeep Chaudhary ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Diabetic Foot ◽

Vitamin D Supplementation ◽

Diabetic Patients ◽

Similar Data ◽

Diabetic Foot Infection ◽

Hydroxyvitamin D ◽

Severe Vitamin ◽

Diabetic Foot Infections

The aim of the present research was to study the prevalence and severity of vitamin D deficiency in patients with diabetic foot infection. Patients were enrolled in two groups: diabetic patients with foot infection (n 125) as cases and diabetic patients without the infection as controls (n 164). Serum 25-hydroxyvitamin D (25(OH)D) was measured by RIA. Data were presented as means and standard deviations unless otherwise indicated and were analysed by SPSS. Results revealed that 25(OH)D (nmol/l) was significantly lower (40·25 (sd 38·35) v. 50·75 (sd 33·00); P < 0·001) in cases than in controls. Vitamin D inadequacy (25(OH)D < 75 nmol/l) was equally common in cases and controls (OR 1·45, 95 % CI 0·8, 3·0; P = 0·32), but cases had a greater risk of vitamin D deficiency (25(OH)D < 50 nmol/l) than controls (OR 1·8, 95 % CI 1·1, 3·0; P = 0·02). Risk of severe vitamin D deficiency (25(OH)D < 25 nmol/l) was significantly higher in cases than in controls (OR 4·0, 95 % CI 2·4, 6·9; P < 0·0001). Age, duration of diabetes and HbA1c were significantly higher in cases than in controls and therefore adjusted to nullify the effect of these variables, if any, on study outcome. The study concluded that vitamin D deficiency was more prevalent and severe in patients with diabetic foot infection. This study opens up the issue of recognising severe vitamin D deficiency ( < 25 nmol/l) as a possible risk factor for diabetic foot infections and the need for vitamin D supplementation in such patients for a better clinical outcome. This could be substantiated by similar data from future studies.

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Effect of vitamin D supplementation in combination with weight loss diet on lipid profile and sirtuin 1 in obese subjects with vitamin D deficiency: a double blind randomized clinical trial

Health Promotion Perspectives ◽

10.15171/hpp.2019.36 ◽

2019 ◽

Vol 9 (4) ◽

pp. 263-269

Author(s):

Soodabeh Aliashrafi ◽

Seyed Rafie- Arefhosseini ◽

Lida Lotfi-Dizaji ◽

Mehrangiz Ebrahimi-Mameghani

Keyword(s):

Vitamin D ◽

Placebo Group ◽

Lipid Profile ◽

Vitamin D Deficiency ◽

Density Lipoprotein ◽

Vitamin D Supplementation ◽

Mean Difference ◽

Sirtuin 1 ◽

Obese Subjects ◽

Mean Differences

Background: Due to inconsistent evidence regarding the potential role of vitamin D on lipid profile and sirtuin 1 (SIRT-1), this study was designed to investigate the effect of vitamin D supplementation in combination with weight loss diet on lipid profile and SIRT-1 in obese subjects with vitamin D deficiency. Methods: Forty-four obese subjects with vitamin D deficiency were randomly assigned in a randomized clinical trial to receive either a weight reduction diet supplemented with 50000IU vitamin D3 pearl (n = 22) or placebo (n = 22) once weekly for 12 weeks. Changes in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and low high density lipoprotein cholesterol (HDL-C) and SIRT-1 were the primary outcomes. Secondary outcomes were changes in body mass index (BMI), 25(OH) D and parathyroid hormone (PTH). Physical activity and dietary intakes were also assessed. Results: During the intervention, PTH (mean difference, -33.36; 95% CI: -49.15 to -17.57;P<0.001) and LDL-C (mean difference, -15.91; 95% CI: -21.76 to -10.07; P<0.001) decreased and 25(OH) D (mean difference, 36.44; 95% CI: 29.05 to 43.83; P<0.001) increased significantly in the vitamin D group. BMI (mean differences: -2.40; 95% CI: [-2.92 to-1.88] in vitamin D group and mean differences: -1.90; 95% CI [-6.58 to -3.01] in placebo group, P<0.05 for both groups), TC (mean difference,-21.31; 95% CI: -27.24 to -15.38; P<0.001 in vitamin D group and mean difference, -12.54; 95% CI: -19.02 to -6.06; P<0.001 in placebo group) and TG (mean difference,-21.31; 95% CI: -27.24 to -15.38; P<0.001in vitamin D group and mean difference, -12.54; 95% CI: -19.02 to -6.06; P<0.001 in placebo group) decreased and SIRT-1(mean difference, 3.95; 95% CI: 1.18 to 6.73; P=0.007in vitamin D group and mean difference,1.91; 95% CI: 0.31 to 3.63 in placebo group, P=0.022) increase significantly in both group. At end of the study, 25(OH) D and PTH showed significant differences in between-group analyses(P<0.05). No significant difference was detected for HDL-C in within and between groups. Conclusion: This study gives no support for any beneficial effect of vitamin D supplementation on lipid profile and SIRT-1 in obese subjects with vitamin D deficiency.

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