scholarly journals Major Adverse Cardiovascular Events Following Simultaneous Pancreas and Kidney Transplantation in the United Kingdom

Diabetes Care ◽  
2019 ◽  
Vol 42 (4) ◽  
pp. 665-673 ◽  
Author(s):  
Petros Yiannoullou ◽  
Angela Summers ◽  
Shu C. Goh ◽  
Catherine Fullwood ◽  
Hussein Khambalia ◽  
...  
Keyword(s):  
United Kingdom ◽  
Kidney Transplantation ◽  
Cardiovascular Events ◽  
Major Adverse Cardiovascular Events ◽  
The United Kingdom

scholarly journals Identification and Validation of Major Cardiovascular Events in the United Kingdom Data Sources Included in a Multi-database Post-authorization Safety Study of Prucalopride

Drug Safety ◽  
2021 ◽  
Vol 44 (5) ◽  
pp. 541-551
Author(s):  
Ana Ruigómez ◽  
Estel Plana ◽  
Alicia Gilsenan ◽  
Joan Fortuny ◽  
Miguel Cainzos-Achirica ◽  
...  
Keyword(s):  
United Kingdom ◽  
Cardiovascular Events ◽  
Data Sources ◽  
Safety Study ◽  
Major Cardiovascular Events ◽  
The United Kingdom

scholarly journals Utilization and Outcomes of Single and Dual Kidney Transplants from Older Deceased Donors in the United Kingdom

2020 ◽  
Vol 15 (9) ◽  
pp. 1320-1329
Author(s):  
Maria Ibrahim ◽  
George H.B. Greenhall ◽  
Dominic M. Summers ◽  
Lisa Mumford ◽  
Rachel Johnson ◽  
...  
Keyword(s):  
United Kingdom ◽  
Kidney Transplantation ◽  
Propensity Score ◽  
Graft Survival ◽  
Propensity Score Analysis ◽  
Kidney Transplants ◽  
The United Kingdom ◽  
Score Analysis ◽  
Deceased Donors ◽  
Single Kidney

Background and objectivesKidneys from elderly deceased donors are often discarded after procurement if the expected outcomes from single kidney transplantation are considered unacceptable. An alternative is to consider them for dual kidney transplantation. We aimed to examine the utilization of kidneys from donors aged ≥60 years in the United Kingdom and compare clinical outcomes of dual versus single kidney transplant recipients.Design, setting, participants, & measurementsData from the United Kingdom Transplant Registry from 2005 to 2017 were analyzed. We examined utilization rates of kidneys retrieved from deceased donors aged ≥60 years, and 5-year patient and death-censored graft survival of recipients of dual and single kidney transplants. Secondary outcomes included eGFR. Multivariable analyses and propensity score analysis were used to correct for differences between the groups.ResultsDuring the study period, 7841 kidneys were procured from deceased donors aged ≥60 years, of which 1338 (17%) were discarded; 356 dual and 5032 single kidneys were transplanted. Donors of dual transplants were older (median, 73 versus 66 years; P<0.001) and had higher United States Kidney Donor Risk Indices (2.48 versus 1.98; P<0.001). Recipients of dual transplants were also older (64 versus 61 years; P<0.001) and had less favorable human leukocyte antigen matching (P<0.001). After adjusting for confounders, dual and single transplants had similar 5-year graft survival (hazard ratio, 0.81; 95% CI, 0.59 to 1.12). No difference in patient survival was demonstrated. Similar findings were observed in a matched cohort with a propensity score analysis method. Median 12-month eGFR was significantly higher in the dual kidney transplant group (40 versus 36 ml/min per 1.73 m2; P<0.001).ConclusionsRecipients of kidneys from donors aged ≥60 years have similar 5-year graft survival and better graft function at 12 months with dual compared with single deceased donor kidney transplants.

scholarly journals Inequity in Access to Transplantation in the United Kingdom

2020 ◽  
Vol 15 (6) ◽  
pp. 830-842 ◽  
Author(s):  
Rishi Pruthi ◽  
Matthew L. Robb ◽  
Gabriel C. Oniscu ◽  
Charles Tomson ◽  
Andrew Bradley ◽  
...  
Keyword(s):  
Health Care ◽  
United Kingdom ◽  
Kidney Transplantation ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Practice Patterns ◽  
Universal Health Care ◽  
The United Kingdom ◽  
Universal Health Care System ◽  
Universal Health

Background and objectivesDespite the presence of a universal health care system, it is unclear if there is intercenter variation in access to kidney transplantation in the United Kingdom. This study aims to assess whether equity exists in access to kidney transplantation in the United Kingdom after adjustment for patient-specific factors and center practice patterns.Design, setting, participants, & measurements In this prospective, observational cohort study including all 71 United Kingdom kidney centers, incident RRT patients recruited between November 2011 and March 2013 as part of the Access to Transplantation and Transplant Outcome Measures study were analyzed to assess preemptive listing (n=2676) and listing within 2 years of starting dialysis (n=1970) by center.ResultsSeven hundred and six participants (26%) were listed preemptively, whereas 585 (30%) were listed within 2 years of commencing dialysis. The interquartile range across centers was 6%–33% for preemptive listing and 25%–40% for listing after starting dialysis. Patient factors, including increasing age, most comorbidities, body mass index >35 kg/m2, and lower socioeconomic status, were associated with a lower likelihood of being listed and accounted for 89% and 97% of measured intercenter variation for preemptive listing and listing within 2 years of starting dialysis, respectively. Asian (odds ratio, 0.49; 95% confidence interval, 0.33 to 0.72) and Black (odds ratio, 0.43; 95% confidence interval, 0.26 to 0.71) participants were both associated with reduced access to preemptive listing; however Asian participants were associated with a higher likelihood of being listed after starting dialysis (odds ratio, 1.42; 95% confidence interval, 1.12 to 1.79). As for center factors, being registered at a transplanting center (odds ratio, 3.1; 95% confidence interval, 2.36 to 4.07) and a universal approach to discussing transplantation (odds ratio, 1.4; 95% confidence interval, 1.08 to 1.78) were associated with higher preemptive listing, whereas using a written protocol was associated negatively with listing within 2 years of starting dialysis (odds ratio, 0.7; 95% confidence interval, 0.58 to 0.9).ConclusionsPatient case mix accounts for most of the intercenter variation seen in access to transplantation in the United Kingdom, with practice patterns also contributing some variation. Socioeconomic inequity exists despite having a universal health care system.

scholarly journals For Estimating Costs in Patients Experiencing Cardiovascular Events Using Utilization Data From The United Kingdom

2016 ◽  
Vol 19 (7) ◽  
pp. A645-A646
Author(s):  
M Danese ◽  
M Gleeson ◽  
L Kutikova ◽  
R Griffiths ◽  
A Azough
Keyword(s):  
United Kingdom ◽  
Cardiovascular Events ◽  
The United Kingdom ◽  
Utilization Data

scholarly journals Lipid Modifying Therapy Treatment Patterns And Cholesterol Control After Cardiovascular Events In The United Kingdom

2015 ◽  
Vol 18 (7) ◽  
pp. A406
Author(s):  
M Danese ◽  
M Gleeson ◽  
L Kutikova ◽  
R Griffiths ◽  
K Khunti ◽  
...  
Keyword(s):  
United Kingdom ◽  
Cardiovascular Events ◽  
Treatment Patterns ◽  
The United Kingdom ◽  
Cholesterol Control ◽  
Therapy Treatment

scholarly journals Sex, Age, and Socioeconomic Differences in Nonfatal Stroke Incidence and Subsequent Major Adverse Outcomes

Stroke ◽  
2021 ◽  
Vol 52 (2) ◽  
pp. 396-405
Author(s):  
Ralph K. Akyea ◽  
Yana Vinogradova ◽  
Nadeem Qureshi ◽  
Riyaz S. Patel ◽  
Evangelos Kontopantelis ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
United Kingdom ◽  
Adverse Outcomes ◽  
Nonfatal Stroke ◽  
Practice Research ◽  
Major Adverse Cardiovascular Events ◽  
Clinical Practice Research Datalink ◽  
Socioeconomic Differences ◽  
Stroke Incidence ◽  
The United Kingdom

Background and Purpose: Data about variations in stroke incidence and subsequent major adverse outcomes are essential to inform secondary prevention and prioritizing resources to those at the greatest risk of major adverse end points. We aimed to describe the age, sex, and socioeconomic differences in the rates of first nonfatal stroke and subsequent major adverse outcomes. Methods: The cohort study used linked Clinical Practice Research Datalink and Hospital Episode Statistics data from the United Kingdom. The incidence rate (IR) ratio of first nonfatal stroke and subsequent major adverse outcomes (composite major adverse cardiovascular events, recurrent stroke, cardiovascular disease-related, and all-cause mortality) were calculated and presented by year, sex, age group, and socioeconomic status based on an individual’s location of residence, in adults with incident nonfatal stroke diagnosis between 1998 and 2017. Results: A total of 82 774 first nonfatal stroke events were recorded in either primary care or hospital data—an IR of 109.20 per 100 000 person-years (95% CI, 108.46–109.95). Incidence was significantly higher in women compared with men (IR ratio, 1.13 [95% CI, 1.12–1.15]; P <0.001). Rates adjusted for age and sex were higher in the lowest compared with the highest socioeconomic status group (IR ratio, 1.10 [95% CI, 1.08–1.13]; P <0.001). For subsequent major adverse outcomes, the overall incidence for major adverse cardiovascular event was 38.05 per 100 person-years (95% CI, 37.71–38.39) with a slightly higher incidence in women compared with men (38.42 versus 37.62; IR ratio, 1.02 [95% CI, 1.00–1.04]; P =0.0229). Age and socioeconomic status largely accounted for the observed higher incidence of adverse outcomes in women. Conclusions: In the United Kingdom, incidence of initial stroke and subsequent major adverse outcomes are higher in women, older populations, and people living in socially deprived areas.

scholarly journals Pre-Transplant Left Ventricular Geometry and Major Adverse Cardiovascular Events After Kidney Transplantation

2019 ◽  
Vol 24 ◽  
pp. 100-107
Author(s):  
Rohit Malyala ◽  
Lindita Rapi ◽  
Michelle M. Nash ◽  
G. V. Ramesh Prasad
Keyword(s):  
Kidney Transplantation ◽  
Cardiovascular Events ◽  
Left Ventricular ◽  
Left Ventricular Geometry ◽  
Major Adverse Cardiovascular Events ◽  
Ventricular Geometry

scholarly journals Ethnicity matching and outcomes after kidney transplantation in the United Kingdom

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195038 ◽  
Author(s):  
Bhavini Pisavadia ◽  
Adam Arshad ◽  
Imogen Chappelow ◽  
Peter Nightingale ◽  
Benjamin Anderson ◽  
...  
Keyword(s):  
United Kingdom ◽  
Kidney Transplantation ◽  
The United Kingdom

scholarly journals Belatacept, kidney transplantation and COVID‐19: Successful management of the first reported case within the United Kingdom

2020 ◽  
Vol 34 (9) ◽  
Author(s):  
Syed Hasan Ahmad ◽  
Richard Smith ◽  
Brian Camilleri
Keyword(s):  
United Kingdom ◽  
Kidney Transplantation ◽  
Successful Management ◽  
The United Kingdom
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