Enzymes of glucose metabolism and of the citrate cleavage pathway in adipose tissue of normal and diabetic subjects

Diabetes ◽  
1975 ◽  
Vol 24 (10) ◽  
pp. 865-873 ◽  
Author(s):  
F. Belfiore ◽  
A. M. Rabuazzo ◽  
E. Napoli ◽  
V. Borzi ◽  
L. Lo Vecchio
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism

scholarly journals Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 554
Author(s):  
Stefania Croce ◽  
Maria Antonietta Avanzini ◽  
Corrado Regalbuto ◽  
Erika Cordaro ◽  
Federica Vinci ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Th17 Cells ◽  
Metabolic Disorders ◽  
Potential Role ◽  
Immune Monitoring ◽  
Metabolic Dysfunction ◽  
Impaired Glucose Metabolism ◽  
T Cell Infiltration

In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Some studies demonstrated that peripheral Treg and Th17 cells exhibit increased imbalance with worsening of glucose metabolic dysfunction, already in children with obesity. In this review, we considered the role of adipose tissue immunomodulation and the potential role played by Treg/T17 imbalance on the impaired glucose metabolism in pediatric obesity. In the patient care, immune monitoring could play an important role to define preventive strategies of pediatric metabolic disease treatments.

HORMONAL REGULATION OF GLUCOSE METABOLISM IN ADIPOSE TISSUE IN VITRO

1965 ◽  
Vol 131 (1 Adipose Tissu) ◽  
pp. 43-58 ◽  
Author(s):  
Bernard R. Landau ◽  
Joseph Katz ◽  
Glenn E. Bartsch ◽  
Lawrence W. White ◽  
Hollis R. Williams
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Hormonal Regulation ◽  
Adipose Tissue In Vitro

scholarly journals Fad24 Causes Hyperplasia in Adipose Tissue and Improves Glucose Metabolism

2009 ◽  
Vol 32 (10) ◽  
pp. 1656-1664 ◽  
Author(s):  
Yoshikazu Johmura ◽  
Kayoko Watanabe ◽  
Keishi Kishimoto ◽  
Takashi Ueda ◽  
Shoichi Shimada ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism

scholarly journals Glucose Metabolism and the Response to Insulin by Human Adipose Tissue in Spontaneous and Experimental Obesity

1974 ◽  
Vol 53 (3) ◽  
pp. 848-856 ◽  
Author(s):  
L. B. Salans ◽  
G. A. Bray ◽  
S. W. Cushman ◽  
E. Danforth ◽  
J. A. Glennon ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Human Adipose Tissue

Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse

2018 ◽  
Vol 36 (1-2) ◽  
pp. 78-88 ◽  
Author(s):  
Deike Hesse ◽  
Jan Trost ◽  
Nadine Schäfer ◽  
Kristin Schwerbel ◽  
Andreas Hoeflich ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Tissue Mass ◽  
Igf I ◽  
Adipose Tissue Mass

scholarly journals Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time

Gut ◽  
2019 ◽  
Vol 69 (3) ◽  
pp. 502-512 ◽  
Author(s):  
Pieter de Groot ◽  
Torsten Scheithauer ◽  
Guido J Bakker ◽  
Andrei Prodan ◽  
Evgeni Levin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Bile Acids ◽  
Transit Time ◽  
Intestinal Transit ◽  
Faecal Microbiota ◽  
Intestinal Transit Time ◽  
Insulin Resistant

ObjectiveBariatric surgery improves glucose metabolism. Recent data suggest that faecal microbiota transplantation (FMT) using faeces from postbariatric surgery diet-induced obese mice in germ-free mice improves glucose metabolism and intestinal homeostasis. We here investigated whether allogenic FMT using faeces from post-Roux-en-Y gastric bypass donors (RYGB-D) compared with using faeces from metabolic syndrome donors (METS-D) has short-term effects on glucose metabolism, intestinal transit time and adipose tissue inflammation in treatment-naïve, obese, insulin-resistant male subjects.DesignSubjects with metabolic syndrome (n=22) received allogenic FMT either from RYGB-D or METS-D. Hepatic and peripheral insulin sensitivity as well as lipolysis were measured at baseline and 2 weeks after FMT by hyperinsulinaemic euglycaemic stable isotope (2H2-glucose and 2H5-glycerol) clamp. Secondary outcome parameters were changes in resting energy expenditure, intestinal transit time, faecal short-chain fatty acids (SCFA) and bile acids, and inflammatory markers in subcutaneous adipose tissue related to intestinal microbiota composition. Faecal SCFA, bile acids, glycaemic control and inflammatory parameters were also evaluated at 8 weeks.ResultsWe observed a significant decrease in insulin sensitivity 2 weeks after allogenic METS-D FMT (median rate of glucose disappearance: from 40.6 to 34.0 µmol/kg/min; p<0.01). Moreover, a trend (p=0.052) towards faster intestinal transit time following RYGB-D FMT was seen. Finally, we observed changes in faecal bile acids (increased lithocholic, deoxycholic and (iso)lithocholic acid after METS-D FMT), inflammatory markers (decreased adipose tissue chemokine ligand 2 (CCL2) gene expression and plasma CCL2 after RYGB-D FMT) and changes in several intestinal microbiota taxa.ConclusionAllogenic FMT using METS-D decreases insulin sensitivity in metabolic syndrome recipients when compared with using post-RYGB-D. Further research is needed to delineate the role of donor characteristics in FMT efficacy in human insulin-resistant subjects.Trial registration numberNTR4327.

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