Development of a Miniaturized Glucose Monitoring System by Combining a Needle-Type Glucose Sensor With Microdialysis Sampling Method: Long-term subcutaneous tissue glucose monitoring in ambulatory diabetic patients

Diabetes Care ◽  
1994 ◽  
Vol 17 (5) ◽  
pp. 387-396 ◽  
Author(s):  
Y. Hashiguchi ◽  
M. Sakakida ◽  
K. Nishida ◽  
T. Uemura ◽  
K.-I. Kajiwara ◽  
...  
Keyword(s):  
Monitoring System ◽  
Sampling Method ◽  
Glucose Sensor ◽  
Subcutaneous Tissue ◽  
Glucose Monitoring ◽  
Diabetic Patients ◽  
Microdialysis Sampling ◽  
Needle Type

scholarly journals Electrochemically Activated Conductive Ni-Based MOFs for Non-enzymatic Sensors Toward Long-Term Glucose Monitoring

2020 ◽  
Vol 8 ◽  
Author(s):  
Yating Chen ◽  
Yulan Tian ◽  
Ping Zhu ◽  
Liping Du ◽  
Wei Chen ◽  
...  
Keyword(s):  
Continuous Glucose Monitoring ◽  
Glucose Sensor ◽  
Glucose Monitoring ◽  
Glucose Sensors ◽  
Blood Glucose Monitoring ◽  
Diabetic Patients ◽  
Potential Range ◽  
Potential Applications ◽  
Naoh Solution

Continuous intensive monitoring of glucose is one of the most important approaches in recovering the quality of life of diabetic patients. One challenge for electrochemical enzymatic glucose sensors is their short lifespan for continuous glucose monitoring. Therefore, it is of great significance to develop non-enzymatic glucose sensors as an alternative approach for long-term glucose monitoring. This study presented a highly sensitive and selective electrochemical non-enzymatic glucose sensor using the electrochemically activated conductive Ni3(2,3,6,7,10,11-hexaiminotriphenylene)2 MOFs as sensing materials. The morphology and structure of the MOFs were investigated by scanning SEM and FTIR, respectively. The performance of the activated electrode toward the electrooxidation of glucose in alkaline solution was evaluated with cyclic voltammetry technology in the potential range from 0.2 V to 0.6 V. The electrochemical activated Ni-MOFs exhibited obvious anodic (0.46 V) and cathodic peaks (0.37 V) in the 0.1 M NaOH solution due to the Ni(II)/Ni(III) transfer. A linear relationship between the glucose concentrations (ranging from 0 to 10 mM) and anodic peak currents with R2 = 0.954 was obtained. It was found that the diffusion of glucose was the limiting step in the electrochemical reaction. The sensor exhibited good selectivity toward glucose in the presence of 10-folds uric acid and ascorbic acid. Moreover, this sensor showed good long-term stability for continuous glucose monitoring. The good selectivity, stability, and rapid response of this sensor suggests that it could have potential applications in long-term non-enzymatic blood glucose monitoring.

966-P: The Long-Term Impact of a Flash Glucose Monitoring System on Glycemic Control

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 966-P
Author(s):  
ATSUSHI FUJIYA ◽  
TOSHIKI KIYOSE ◽  
TAIGA SHIBATA ◽  
HIROSHI SOBAJIMA
Keyword(s):  
Glycemic Control ◽  
Monitoring System ◽  
Glucose Monitoring ◽  
Flash Glucose Monitoring ◽  
Long Term Impact ◽  
Flash Glucose Monitoring System

scholarly journals Further Evidence of Severe Allergic Contact Dermatitis From Isobornyl Acrylate While Using a Continuous Glucose Monitoring System

2018 ◽  
Vol 12 (3) ◽  
pp. 630-633 ◽  
Author(s):  
Stefanie Kamann ◽  
Olivier Aerts ◽  
Lutz Heinemann
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Monitoring System ◽  
Continuous Glucose Monitoring ◽  
Glucose Sensor ◽  
Skin Irritation ◽  
Glucose Monitoring ◽  
Gas Chromatography Mass Spectrometry ◽  
Skin Reactions ◽  
Allergic Contact

In the past decade, new diabetes technologies, including continuous glucose monitoring (CGM) systems, support patients with diabetes in their daily struggle with achieving a good glucose control. However, shortly after the first CGM systems appeared on the market, also the first concerns about adverse skin reactions were raised. Most patients claimed to suffer from (sometimes severe) skin irritation, or even allergy, which they related to the (acrylate-based) adhesive part of the device. For a long time the actual substance that caused these skin reactions with, for example, the Flash Glucose Monitoring system (iscCGM; Freestyle® Libre) could not be identified; however, recently Belgian and Swedish dermatologists reported that the majority of their patients that have developed a contact-allergic while using iscCGM react sensitively to a specific acrylate, that is, isobornyl acrylate (IBOA). Subsequently they showed by means of gas chromatography-mass spectrometry that this substance is present in the case of the glucose sensor attached by an adhesive to the skin. We report three additional cases from Germany, including a 10-year-old boy, suffering from severe allergic contact dermatitis to IBOA.

scholarly journals Noninvasive Electromagnetic Wave Sensing of Glucose

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1151 ◽  
Author(s):  
Ruochong Zhang ◽  
Siyu Liu ◽  
Haoran Jin ◽  
Yunqi Luo ◽  
Zesheng Zheng ◽  
...  
Keyword(s):  
Review Paper ◽  
Glucose Monitoring ◽  
Fundamental Principle ◽  
Glucose Sensors ◽  
Glucose Measurement ◽  
Thz Spectroscopy ◽  
Diabetic Patients ◽  
Fda Approval ◽  
Finger Prick

Diabetic patients need long-term and frequent glucose monitoring to assist in insulin intake. The current finger-prick devices are painful and costly, which places noninvasive glucose sensors in high demand. In this review paper, we list several advanced electromagnetic (EM)-wave-based technologies for noninvasive glucose measurement, including infrared (IR) spectroscopy, photoacoustic (PA) spectroscopy, Raman spectroscopy, fluorescence, optical coherence tomography (OCT), Terahertz (THz) spectroscopy, and microwave sensing. The development of each method is discussed regarding the fundamental principle, system setup, and experimental results. Despite the promising achievements that have been previously reported, no established product has obtained FDA approval or survived a marketing test. The limitations of, and prospects for, these techniques are presented at the end of this review.

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