scholarly journals The Absence of Interleukin-6 Enhanced Arsenite-Induced Renal Injury by Promoting Autophagy of Tubular Epithelial Cells with Aberrant Extracellular Signal-Regulated Kinase Activation

2010 ◽  
Vol 176 (1) ◽  
pp. 40-50 ◽  
Author(s):  
Akihiko Kimura ◽  
Yuko Ishida ◽  
Takashi Wada ◽  
Tomoko Hisaoka ◽  
Yoshihiro Morikawa ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Interleukin 6 ◽  
Renal Injury ◽  
Tubular Epithelial Cells ◽  
Kinase Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils

2005 ◽  
Vol 35 (9) ◽  
pp. 2728-2737 ◽  
Author(s):  
Carol Ward ◽  
Joanna Murray ◽  
April Clugston ◽  
Ian Dransfield ◽  
Christopher Haslett ◽  
...  
Keyword(s):  
Interleukin 10 ◽  
Human Neutrophils ◽  
Kinase Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Role of Stat3 Signaling in Control of EMT of Tubular Epithelial Cells During Renal Fibrosis

2017 ◽  
Vol 42 (6) ◽  
pp. 2552-2558 ◽  
Author(s):  
Jingsong Liu ◽  
Ying Zhong ◽  
Guoyong Liu ◽  
Xiaobai Zhang ◽  
Bofei Xiao ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Renal Injury ◽  
Renal Fibrosis ◽  
Critical Role ◽  
Dependent Manner ◽  
Tubular Epithelial Cells ◽  
Mesenchymal Transition ◽  
Stat3 Signaling ◽  
Phosphorylated Stat3

Background/Aims: Transforming growth factor β 1 (TGFβ1) plays a critical role in the epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells (TECs) during renal injury, a major cause of acute renal failure, renal fibrosis and obstructive nephropathy. However, the underlying molecular mechanisms remain ill-defined. Here, we addressed this question. Methods: Expression of TGFβ1, Snail, and phosphorylated Stat3 was examined by immunohistochemistry in the kidney after induction of unilateral ureteral obstruction (UUO) in mice. In vitro, primary TECs were purified by flow cytometry, and then challenged with TGFβ1 with/without presence of specific inhibitors for phosphorylation of SMAD3 or Stat3. Protein levels were determined by Western blotting. Results: We detected significant increases in Snail and phosphorylated Stat3, an activated form for Stat3, in the kidney after induction of UUO in mice. In vitro, TGFβ1-challenged primary TECs upregulated Snail, in a SMAD3/Stat3 dependent manner. Conclusion: Our study sheds light on the mechanism underlying the EMT of TECs after renal injury, and suggests Stat3 signaling as a promising innovative therapeutic target for prevention of renal fibrosis.

scholarly journals Cue-Elicited Reward-Seeking Requires Extracellular Signal-Regulated Kinase Activation in the Nucleus Accumbens

2008 ◽  
Vol 28 (6) ◽  
pp. 1434-1443 ◽  
Author(s):  
M. W. Shiflett ◽  
R. P. Martini ◽  
J. C. Mauna ◽  
R. L. Foster ◽  
E. Peet ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Kinase Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Reward Seeking ◽  
Extracellular Signal

Cyclooxygenase-2 Up-Regulates Ataxia Telangiectasia and Rad3 Related through Extracellular Signal-Regulated Kinase Activation

2009 ◽  
Vol 7 (7) ◽  
pp. 1158-1168 ◽  
Author(s):  
Young Mee Kim ◽  
Eun Jung Lee ◽  
Soo-Yeon Park ◽  
Kwan Ho Cho ◽  
Joo Young Kim ◽  
...  
Keyword(s):  
Ataxia Telangiectasia ◽  
Cyclooxygenase 2 ◽  
Kinase Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal
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