scholarly journals Behavioral and Laboratory Abnormalities in Rat Offspring Exposed to Fipronil during the Perinatal Period

2018 ◽  
Vol 7 (1) ◽  
pp. 356-373 ◽  
Author(s):  
Francisco Pizzolato Montanha ◽  
◽  
Caique Aparecido Faria ◽  
Faber Daniel Machado ◽  
Fábio Anselmo ◽  
...  
Keyword(s):  
Perinatal Period ◽  
Rat Offspring

Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration

2007 ◽  
Vol 197 (1) ◽  
pp. 83-94 ◽  
Author(s):  
Lindsay Naef ◽  
Lalit Srivastava ◽  
Alain Gratton ◽  
Howard Hendrickson ◽  
S. Michael Owens ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Behavioral Responses ◽  
Perinatal Period ◽  
High Fat ◽  
Adult Rat ◽  
Rat Offspring ◽  
Amphetamine Administration

scholarly journals Effects of Perinatal Fluoxetine Exposure on Novelty-induced Social and Non-Social Investigation Behaviors in a Seminatural Environment

2021 ◽  
Author(s):  
Ole Christian Sylte ◽  
Jesper Solheim Johansen ◽  
Indrek Heinla ◽  
Danielle J Houwing ◽  
Jocelien DA Olivier ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Perinatal Period ◽  
Female Offspring ◽  
Social Aspects ◽  
Perinatal Exposure ◽  
Social Investigation ◽  
Adult Rat ◽  
Rat Offspring ◽  
Males And Females

AbstractSelective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various affective disorders during pregnancy. SSRIs cross the placenta and affect serotonergic neurotransmission in the fetus, but the neurobehavioral consequences for the offspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations in both social and non-social aspects of behavior. However, this research has mainly focused on behavior within simplified environments. The current study investigates the effects of perinatal SSRI exposure on social and non-social investigation behaviors of adult rat offspring upon introduction to a novel seminatural environment with unknown conspecifics. During the perinatal period (gestational day 1 until postnatal day 21), rat dams received daily treatment with either an SSRI (fluoxetine, 10 mg/kg) or vehicle. Adult male and female offspring were observed within the first hour after introduction to a seminatural environment. The results showed that perinatal fluoxetine exposure altered aspects of non-social investigation behaviors, while not altering social investigation behaviors. More specific, both fluoxetine exposed males and females spent more total time on locomotor activity than controls. Furthermore, fluoxetine exposed females spent less time exploring objects and specific elements in the environment. The data suggest that perinatal exposure to SSRIs leads to a quicker, less detailed investigation strategy in novel environments, and that the alteration is mostly pronounced in females.

scholarly journals Perinatal undernutrition programmes thyroid function in the adult rat offspring

2013 ◽  
Vol 110 (12) ◽  
pp. 2207-2215 ◽  
Author(s):  
Rosario Ayala-Moreno ◽  
Radu Racotta ◽  
Brenda Anguiano ◽  
Carmen Aceves ◽  
Lucía Quevedo
Keyword(s):  
Thyroid Function ◽  
Perinatal Period ◽  
Control Group ◽  
Free Access ◽  
Commercial Diet ◽  
Adult Rat ◽  
Rat Offspring ◽  
Brown Adipose ◽  
Fat Depot ◽  
Tsh Levels

Increasing evidence suggests that alterations in early nutrition programme physiological changes in adulthood. In the present study, we determined the effects of undernutrition during gestation and lactation on the programming of thyroid function in adult rat offspring. Perinatal undernutrition was achieved by a 40 % food restriction in female Wistar rats from the mating day to weaning. On postpartum day 21, the offspring of the control and food-restricted dams were weaned and given free access to a commercial diet until adulthood. The results showed that undernourished rats exhibited decreased 3,5,3′-triiodothyronine (T3) levels but had normal thyroxine (T4) and thyrotropin (TSH) levels at weaning; on day 90, these rats displayed a significant flip, exhibiting normalised T3(total and free) and total T4levels, but low free T4and persistently higher TSH levels, which were maintained even on postnatal day 140. This profile was accompanied by a scarce fat depot, a lower RMR and an exacerbated sympathetic brown adipose tissue (BAT) tone (deiodinase type 2 expression) in basal conditions. Moreover, when a functional challenge (cold exposure) was applied, the restricted group exhibited partial changes in TSH (29v.100 %) and T4(non-responsev.17 %) levels, a significant decrease in leptin levels (75v. 32 %) and the maintenance of a sympathetic BAT over-response (higher noradrenaline levels) in comparison with the control group. The findings of the present study suggest that undernutrition during the perinatal period produces permanent changes in the hypothalamus–pituitary–thyroid axis with consequent low body weight and decreased RMR and facultative thermogenesis. We hypothesise that these changes predispose individuals to exhibiting adult subclinical hypothyroidism.

Effects of a Westernized Diet on the Reflexes and Physical Maturation of Male Rat Offspring During the Perinatal Period

Lipids ◽  
2013 ◽  
Vol 48 (11) ◽  
pp. 1157-1168 ◽  
Author(s):  
Taisy Cinthia Ferro Cavalcante ◽  
Jennyffer Mayara Lima da Silva ◽  
Amanda Alves da Marcelino da Silva ◽  
Gisélia Santana Muniz ◽  
Laércio Marques da Luz Neto ◽  
...  
Keyword(s):  
Perinatal Period ◽  
Male Rat ◽  
Rat Offspring ◽  
Physical Maturation ◽  
Westernized Diet

scholarly journals Effects of perinatal fluoxetine exposure on novelty-induced social and non-social investigation behaviors in a seminatural environment

2021 ◽  
Author(s):  
Ole Christian Sylte ◽  
Jesper Solheim Johansen ◽  
Indrek Heinla ◽  
Danielle J. Houwing ◽  
Jocelien D. A. Olivier ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Perinatal Period ◽  
Female Offspring ◽  
Social Aspects ◽  
Perinatal Exposure ◽  
Social Investigation ◽  
Adult Rat ◽  
Rat Offspring ◽  
Males And Females

AbstractSelective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various affective disorders during pregnancy. SSRIs cross the placenta and affect serotonergic neurotransmission in the fetus, but the neurobehavioral consequences for the offspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations in both social and non-social aspects of behavior. However, this research has mainly focused on behavior within simplified environments. The current study investigates the effects of perinatal SSRI exposure on social and non-social investigation behaviors of adult rat offspring upon introduction to a novel seminatural environment with unknown conspecifics. During the perinatal period (gestational day 1 until postnatal day 21), rat dams received daily treatment with either an SSRI (fluoxetine, 10 mg/kg) or vehicle. Adult male and female offspring were observed within the first hour after introduction to a seminatural environment. The results showed that perinatal fluoxetine exposure altered aspects of non-social investigation behaviors, while not altering social investigation behaviors. More specifically, both fluoxetine-exposed males and females spent more total time on locomotor activity than controls. Furthermore, fluoxetine-exposed females spent less time exploring objects and specific elements in the environment. The data suggest that perinatal exposure to SSRIs leads to a quicker, less detailed investigation strategy in novel environments and that the alteration is mostly pronounced in females.

scholarly journals Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165432 ◽  
Author(s):  
María Teresa Ramírez-López ◽  
Raquel Arco ◽  
Juan Decara ◽  
Mariam Vázquez ◽  
Rosario Noemí Blanco ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Perinatal Period ◽  
Cannabinoid System ◽  
Adult Rat ◽  
Rat Offspring ◽  
Palatable Diet ◽  
Endogenous Cannabinoid ◽  
The Brain ◽  
Endogenous Cannabinoid System

Ultrastructural alterations in the fetal mouse myocardium in response to genetic and environmental factors

1987 ◽  
Vol 45 ◽  
pp. 724-725
Author(s):  
K.C. Feng-Chen ◽  
F.B. Essien ◽  
K.J. Prestwidge ◽  
J.T. Cheng ◽  
C.L. Shen
Keyword(s):  
Fetal Heart ◽  
Perinatal Period ◽  
Primary Energy ◽  
Cardiac Contraction ◽  
Ultrastructural Changes ◽  
Fetal Mouse ◽  
The Subject ◽  
Physiological Adjustments ◽  
Genetic And Environmental Factors ◽  
Genetically Determined

The physiology of the fetal heart differs significantly from that of the mature post-natal organ: e.g., the metabolic supply for adult cardiac contraction relies mainly on fatty acids; whereas, the fetal heart uses carbohydrates as its primary energy source. Limited morphological descriptions of the developing myocardium have appeared. However, additional studies are required to elucidate the ultrastructural changes occuring in the perinatal period when enormous physiological adjustments are made. Although adult animals are most often used in toxocological and pathological analyses, it is also important to investigate fetal cardiac responsiveness to various agents. The vulnerability of the ultrastructure of the fetal mouse myocardium to genetic and environmental assault is the subject of this report. The genetically determined effect on the heart was observed in mouse embryos homozygous for the cab (cardiac abnormality) mutation discovered by Essien.

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