Ultrastructural alterations in the fetal mouse myocardium in response to genetic and environmental factors

1987 ◽  
Vol 45 ◽  
pp. 724-725
Author(s):  
K.C. Feng-Chen ◽  
F.B. Essien ◽  
K.J. Prestwidge ◽  
J.T. Cheng ◽  
C.L. Shen
Keyword(s):  
Fetal Heart ◽  
Perinatal Period ◽  
Primary Energy ◽  
Cardiac Contraction ◽  
Ultrastructural Changes ◽  
Fetal Mouse ◽  
The Subject ◽  
Physiological Adjustments ◽  
Genetic And Environmental Factors ◽  
Genetically Determined

The physiology of the fetal heart differs significantly from that of the mature post-natal organ: e.g., the metabolic supply for adult cardiac contraction relies mainly on fatty acids; whereas, the fetal heart uses carbohydrates as its primary energy source. Limited morphological descriptions of the developing myocardium have appeared. However, additional studies are required to elucidate the ultrastructural changes occuring in the perinatal period when enormous physiological adjustments are made. Although adult animals are most often used in toxocological and pathological analyses, it is also important to investigate fetal cardiac responsiveness to various agents. The vulnerability of the ultrastructure of the fetal mouse myocardium to genetic and environmental assault is the subject of this report. The genetically determined effect on the heart was observed in mouse embryos homozygous for the cab (cardiac abnormality) mutation discovered by Essien.

Pharmacogenetics

1962 ◽  
Vol 11 (3) ◽  
pp. 338-350 ◽  
Author(s):  
David A. Price-Evans
Keyword(s):  
Animal Species ◽  
The Subject ◽  
Genetically Determined

The term Pharmacogenetics is defined as the study of genetically determined variations in animal species which are revealed by the effects of drugs.I am going to deal with examples of these variations which have been found in Man. I must apologise for a certain amount of repetition of some facts which have already been aired in this conference, but it is my intention to give you a bird's eye view of the subject.

GENETICS AND METABOLISM

PEDIATRICS ◽  
1960 ◽  
Vol 25 (4) ◽  
pp. 565-571
Author(s):  
Barton Childs
Keyword(s):  
Mutant Gene ◽  
Human Populations ◽  
Affected Patient ◽  
Adrenal Hyperplasia ◽  
Genetic Determination ◽  
The Subject ◽  
Definition Of ◽  
Genetically Determined ◽  
Or Genes

IT IS the part of wisdom when about to give a dissertation which one hopes will at once instruct and entertain, to provide at the outset some definition of the subject matter. Genetics is the study of the heritable components of variation; the heritable factors which determine the range or extent of diversity. So, genetics is concerned with heritable differences and likenesses between individuals and between species. One emphasizes the differences because one can be certain of genetic determination of a particular characteristic only when it exists in a population in two or more alternative forms. It is the variants which catch the eye and hold the attention of the investigator, and which by their presence suggest more than one form of the gene or genes which determine that particular characteristic. I would like in what follows to present some examples of investigations of some aspects of genetics in human populations. ADRENAL HYPERPLASIA Several years ago Dr. Melvin Grumbach and I studied the genetics of adrenal hyperplasia, using as our material the patients of Dr. Lawson Wilkins. Since the disease occurs in more than one member of a sibship and since parents are unaffected, we suspected that it was genetically determined and that the affected patient possessed a double dose of a mutant gene; that is, the characteristic was recessive.

scholarly journals Surface excitations in the modelling of electron transport for electron-beam-induced deposition experiments

2015 ◽  
Vol 6 ◽  
pp. 1260-1267 ◽  
Author(s):  
Francesc Salvat-Pujol ◽  
Roser Valentí ◽  
Wolfgang S Werner
Keyword(s):  
Electron Beam ◽  
Electron Transport ◽  
Primary Energy ◽  
Primary Electron ◽  
Sizeable Fraction ◽  
The Subject ◽  
Electron Beam Induced Deposition ◽  
The One ◽  
Electron Energy Loss ◽  
General Perspective

The aim of the present overview article is to raise awareness of an essential aspect that is usually not accounted for in the modelling of electron transport for focused-electron-beam-induced deposition (FEBID) of nanostructures: Surface excitations are on the one hand responsible for a sizeable fraction of the intensity in reflection-electron-energy-loss spectra for primary electron energies of up to a few kiloelectronvolts and, on the other hand, they play a key role in the emission of secondary electrons from solids, regardless of the primary energy. In this overview work we present a general perspective of recent works on the subject of surface excitations and on low-energy electron transport, highlighting the most relevant aspects for the modelling of electron transport in FEBID simulations.

Le Problème de L'HéréDité Dans les Syndromes Epileptiques, by Renaud Delaveleye. Paris: Expansion Scientifique Français (15, rue Saint-Benoit), 1969, 235 pp., $7.50

PEDIATRICS ◽  
1970 ◽  
Vol 46 (1) ◽  
pp. 169-169
Author(s):  
Cesare T. Lombroso
Keyword(s):  
Reference Material ◽  
Genetic Aspect ◽  
Hereditary Factors ◽  
The Subject ◽  
Genetically Determined ◽  
Vexing Problem

This monograph deals with the eugenically vexing problem of the hereditary factors in epilepsy. Its first section covers quite adequately the literature on the subject, and presents some of the conflicting opinions. In a second section the author presents his own data. His conclusions are that the epilepsies do not show a unitary genetic aspect, but rather they are the resuits of a constellation of factors of which some are genetically determined. A useful monograph results both because of its abundant reference material, and new observations reproted.

scholarly journals interactions between genetic and environmental factors determine direction of population lateralization

2005 ◽  
Vol 28 (4) ◽  
pp. 598-598 ◽  
Author(s):  
chao deng
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Head Rotation ◽  
Head Turning ◽  
Genetic And Environmental Factors ◽  
Genetically Determined

direction of the embyro's head rotation is determined by asymmetrical expression of several genes (such as shh, nodal, lefty, and fgf8) in hensen's node. this genetically determined head-turning bias provides a base for light-aligned population lateralization in chicks, in which the direction of the lateralization is determined by genetic factors and the degree of the lateralization is determined by environmental factors.

Genetics of Pancreatitis

2005 ◽  
Vol 94 (2) ◽  
pp. 103-107 ◽  
Author(s):  
V. Keim
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Autosomal Dominant ◽  
Pancreas Cancer ◽  
Genetic Risk Factors ◽  
The Past ◽  
Cationic Trypsinogen ◽  
The Subject ◽  
Genetically Determined

There was some recent progress in the understanding of genetic risk factors in chronic pancreatitis. Due to this progress some of the traditional views of the subject will change. Today, genetic risk factors are attributed a much more important role that in the past. The frequency and strength of mutations were higher than expected. Strong variants were the rare autosomal-dominant mutations N29I and R122H of PRSS1 (cationic trypsinogen) and homozygous N34S of SPINK1 (pancreatic secretory trypsin inhibitor). Other mutations (heterozygous N34S, CFTR) were of lower relevance but still mediate a higher risk than alcohol consumption. The course of genetically determined pancreatitis is rather mild. In the long term pancreas cancer was found in some patients but apart from non-smoking no adequate prophylactic strategy is available up to now.

scholarly journals Renewable Energy Sources as a Development Opportunity for Peripheral Areas

2020 ◽  
Vol 13 (2) ◽  
pp. 184-198
Author(s):  
Piotr Gradziuk ◽  
Barbara Gradziuk
Keyword(s):  
Renewable Energy ◽  
Renewable Energy Sources ◽  
Primary Energy ◽  
Peripheral Region ◽  
Energy Sources ◽  
Small Scale ◽  
Low Carbon ◽  
Renewable Sources ◽  
Low Carbon Economy ◽  
The Subject

SummarySubject and purpose of work: The subject of this analysis and evaluation is the use of renewable energy sources in Poland, particularly in the Lubelskie Voivodeship, as a peripheral region. The purpose of this paper is to identify the role and evaluate the scale and effects of using renewable energy sources (RES), as well as the availability and absorption of financial resources for RES promotion.Materials and methods: The data were obtained from the Office of the Ruda-Huta Commune, the Regional Operational Programme Department of the Marshal Office of the Lubelskie Voivodeship in Lublin and the Department of European Funds of the Ministry of Energy, as well as Statistics Poland (GUS) and the literature on the subject.Results: In Poland the proportion of energy from renewable sources to the total primary energy generated increased in 2012-2018 from 11.73% to 14.46%. A new phenomenon, which has been highly significant for the development of this sector, is the use of innovative, small-scale technologies of energy generation from renewable sources, which created the foundations for the growth of a citizens’ energy sector, based on the initiative of the citizens and their communities. The use of RES contributes to reduced expenditures on the purchase of energy carriers and constitutes an effective method of implementing plans for developing a low-carbon economy and reducing low-stack emissions.Conclusions: The continuing disparities between the regions point to the need for active structural intervention to maintain economic, social and territorial cohesion, particularly in areas which are considered peripheral and have a very low GDP per capita. One of the preferred directions should be to support the use of RES.

scholarly journals Design and Analysis of Electric Bike

2021 ◽  
pp. 165-171
Author(s):  
Praglbh Shivnay ◽  
Prof. R. S. Yadav
Keyword(s):  
Automobile Industry ◽  
Electrical Power ◽  
Primary Energy ◽  
Pollution Reduction ◽  
Rechargeable Battery ◽  
Major Goal ◽  
Accurate Picture ◽  
The Subject ◽  
The Many ◽  
Electric Bike

The increased demand for electric bikes is the subject of this study. Our main focus is in the automobile industry, where we are converting outdated bicycles to electric bicycles. The major goal of this study is to present an accurate picture by linking the many energy sources that humankind has access to humanity In order for humanity to progress in today's civilized environment, they must travel. And in order to accomplish this, his journey should be as quick and painless as possible. The Electric Bike, which is powered by a battery and so supplies voltage to the motor, is the subject of this study. This study is concerned with the design and construction of an electric bike that runs on electricity as primary energy. In the main system, there is a setting for a rechargeable battery. When compared to a traditional car, the bike's electrical power can deliver better fuel economy, performance, and pollution reduction.

scholarly journals Causal relationships between genetically determined metabolites and human intelligence: A Mendelian randomization study

2020 ◽  
Author(s):  
Jian Yang ◽  
Binbin Zhao ◽  
Li Qian ◽  
Fengjie Gao ◽  
Yanjuan Fan ◽  
...  
Keyword(s):  
Complex Traits ◽  
Mendelian Randomization ◽  
Sensitivity Analyses ◽  
Human Intelligence ◽  
Causal Relationships ◽  
Biological Mechanisms ◽  
Inverse Variance ◽  
Weighted Median ◽  
Genetic And Environmental Factors ◽  
Genetically Determined

Abstract Intelligence predicts important life and health outcomes, but the biological mechanisms underlying differences in intelligence are not yet understood. The use of genetically determined metabotypes (GDMs) to understand the role of genetic and environmental factors, and their interactions, in human complex traits has been recently proposed. However, this strategy has not been applied to human intelligence. Here we implemented a two-sample Mendelian randomization (MR) analysis using GDMs to assess the causal relationships between genetically determined metabolites and human intelligence. The standard inverse-variance weighted (IVW) method was used for the primary MR analysis and three additional MR methods (MR-Egger, weighted median, and MR-PRESSO) were used for sensitivity analyses. Using 25 genetic variants as instrumental variables (IVs), our study found that 5-oxoproline was associated with better performance in human intelligence tests (P IVW = 9 · 25×10 -5 ). The causal relationship was robust when sensitivity analyses were applied (P MR-Egger = 0 · 0001, P Weighted median = 6 · 29×10 -6 , P MR-PRESSO = 0 · 0007), and no evidence of horizontal pleiotropy was observed. Similarly, also dihomo-linoleate (20:2n6) and p-acetamidophenylglucuronide showed robust association with intelligence. Our study provides novel insight by integrating genomics and metabolomics to estimate causal effects of genetically determined metabolites on human intelligence, which help to understanding of the biological mechanisms related to human intelligence.

scholarly journals Osobennosti adaptatsii novorozhdennykh u materey s ozhireniem

2008 ◽  
Vol 5 (2) ◽  
pp. 23-26
Author(s):  
L Yu Zernova ◽  
T V Kovalenko ◽  
N N Popova ◽  
N S Strelkov
Keyword(s):  
Distress Syndrome ◽  
Adjustment Disorder ◽  
Perinatal Period ◽  
Postnatal Period ◽  
Reproductive Disorders ◽  
High Incidence ◽  
Neonatal Adaptation ◽  
The Subject ◽  
Postnatal Adaptation ◽  
Available Information

According to various authors, obesity among pregnant recorded at a frequency of 15.5 to 26.9%. There is strong evidence that obesity contributes to complications of pregnancy, childbirth and the postpartum period, provoking the development of gestosis, placental insufficiency, abnormalities of labor, bleeding, et al., Which suggests the possibility of adjustment disorder in the neonatal period in infants of obese mothers. It should be recognized, however, that the available information on the subject are scarce and fragmentary. The purpose of this study was to investigate the features of postnatal adaptation of newborns of mothers with obesity. According to the study found that obesity in women is associated with a high incidence of reproductive disorders, gestational complications and pathological course of labor, resulting in abnormalities in the neonatal adaptation in the postnatal period. Disadaptation syndrome is manifested by the development of jaundice sustained over, edema, transient changes of the cardiovascular system, hypoglycemia. Violations in health are detected in the majority of infants (83.3%) born to mothers with obesity. The most significant pathologies are infections specific to the perinatal period (40.5%), respiratory distress syndrome (3.6%), diabetic fetopathy (4.8%), congenital malformations (2.4%).

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