scholarly journals Dysregulation mechanism of the influence of water of negative redox potential on kidney function

2020 ◽  
Vol 24 (4 (96)) ◽  
pp. 93-98
Author(s):  
Yu. Rohovyi ◽  
O. Kolesnik ◽  
V. Tsіtrіn
Keyword(s):  
Renal Function ◽  
Redox Potential ◽  
Glomerular Filtration ◽  
Energy Supply ◽  
Contractile Function ◽  
Tap Water ◽  
Sodium Ions ◽  
Filtration Fraction ◽  
Water Loading ◽  
Effect Of Water

Elucidate the dysregulatory mechanism of the effect of water load of negative redox potential in comparison with induced diuresis with ordinary tap water on the functional state of the kidneys.Material and methods. The experiments were carried out on 40 male white nonlinear rats weighing 0.16-0.18 kg with the analysis of the effect of water loading with a negative redox potential on renal function, which was obtained by treating tap water with microhydrin. The redox potential of water and urine was determined with an ORP meter. From the indicators of renal function studied: protein excretion, glomerular filtration, filtration fraction of sodium ions, its absolute and proximal reabsorption. Statistical processing of the data obtained, including multivariate regression analysis, was carried out using the Statgrafics, Statistica, and Excel 2003 programs.Results. Comparative multivariate analysis of the effect of water loading of negative redox potential in comparison with induced diuresis with ordinary tap water revealed an ambiguous nature of reliable correlations (p <0.05) between the studied indicators of renal function and the redox potential of urine, which is due to the simultaneous presence of both protective mechanisms of negative redox potential influence (improvement of energy supply, antioxidant effect), and damaging (transient renal ischemia due to activation of the basal tone mechanism due to an increase in the contractile function of the heart as a result of improving its energy supply), the final result will depend on the dominance of classical or dysregulation mechanisms in this particular situation. Conclusion. The dysregulation mechanism of the effect of water of negative redox potential on renal function is due to the initial mobilization of defense reactions with improved contractile function of the heart, which is subsequently transformed into an injury response due to increased basal renal vascular tone with the development of transient ischemia and renal dysfunction, decrease оf glomerular filtration, filtration fraction of sodium ions, its absolute and proximal reabsorption and development of proteinuria.

scholarly journals RENAL FUNCTION DURING CHRONIC ANEMIA IN MAN

Blood ◽  
1947 ◽  
Vol 2 (2) ◽  
pp. 192-202 ◽  
Author(s):  
STANLEY E. BRADLEY ◽  
GERALDINE P. BRADLEY
Keyword(s):  
Blood Flow ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Normal Values ◽  
Renal Plasma Flow ◽  
Filtration Fraction ◽  
Chronic Anemia

Abstract 1. Renal function has been studied quantitatively in 15 patients with chronic anemia, 8 of whom were proved to have pernicious anemia. In 7 the anemia was secondary to chronic blood loss, iron deficiency, paroxysmal nocturnal hemoglobinuria, and leukemia. The effective renal plasma flow and glomerular filtration rate were measured by clearance technics; and tubular function, by saturation methods (diodrast Tm and glucose Tm). 2. The effective renal plasma flow, the glomerular filtration rate, and the filtration fraction (percentage of plasma filtered at the glomerulus) were reduced slightly below the normal values in most subjects. The effective renal whole blood flow was always greatly reduced, by 46 per cent on the average in males and by 31.8 per cent in females. 3. Since arterial pressure was not significantly depressed it was concluded that renal vasoconstriction occurs in chronic anemia, possibly as a homeostatic device for the diversion of blood to tissues more sensitive to oxygen lack. The relatively small reduction of filtration fraction implies afferent and efferent arteriolar vasoconstriction with dominance by the afferent arterioles. These changes were shown to be reversible, a return to normal values paralleling the return of the blood picture to normal. 4. Diodrast Tm was reduced significantly in 9 of 10 patients while the values of glucose Tm were normal in 6 of 7 patients. The normal values for glucose Tm indicated continued operation of all glomeruli and implied the absence of shunting or of cessation of blood flow in any significant portion of the kidney. The fall in diodrast Tm, which appeared to be reversible in 2 of 4 individuals, was interpreted as evidence of intracellular dysfunction rather than destruction or inactivation of nephrons.

WATER RETENTION IN OBESITY

1959 ◽  
Vol XXXII (I) ◽  
pp. 113-122 ◽  
Author(s):  
H. W. Bansi ◽  
J. M. Olsen
Keyword(s):  
Blood Flow ◽  
Renal Function ◽  
Glomerular Filtration ◽  
Renal Blood Flow ◽  
Water Retention ◽  
Filtration Fraction ◽  
Statistical Probability ◽  
Total Body ◽  
Normal Controls ◽  
Clearance Methods

ABSTRACT In 27 cases of obesity, renal function was examined by clearance methods with a constant plasma level. The results showed that, as compared with normal controls, renal blood flow, glomerular filtration and the filtration fraction were significantly reduced. Therapy with L-tri-iodothyronine (TIT) covered 17 cases of obesity. The influence of the drug on renal function, total body fluids and extracellular fluids was examined. Statistical probability indicated that total body fluid and glomerular filtration were nearly normalised and renal blood flow was significantly increased while the extracellular fluids volume remained unchanged at a low level.

Clinical Renal Function Testing by External Double Isotope Monitoring Technique

1971 ◽  
Vol 10 (01) ◽  
pp. 16-24
Author(s):  
J. Fog Pedersen ◽  
M. Fog Pedersen ◽  
Paul Madsen
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Correlation Coefficients ◽  
Feedback System ◽  
Effective Renal Plasma Flow ◽  
Advantages And Disadvantages

SummaryAn accurate catheter-free technique for clinical determination simultaneouslyof glomerular filtration rate and effective renal plasma flow by means of radioisotopes has been developed. The renal function is estimated by the amount of radioisotopes necessary to maintain a constant concentration in the patient’s blood. The infusion pumps are steered by a feedback system, the pumps being automatically turned on when the radiation measured over the patient’s head falls below a certain preset level and turned off when this level is again readied. 131I-iodopyracet was used for the estimation of effective renal plasma flow and125I-iothalamate estimation of the glomerular filtration rate. These clearances were compared to the conventional bladder clearances and good correlation was found between these two clearance methods (correlation coefficients 0.97 and.90 respectively). The advantages and disadvantages of this new clearance technique are discussed.

STUDY OF RADIATION CHARACTERISTICS THE RENAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES

2014 ◽  
pp. 73-77
Author(s):  
Van Chuong Nguyen ◽  
Thi Kim Anh Nguyen
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Disease Duration ◽  
Left Kidney ◽  
Cross Sectional ◽  
The Right

Background: A Research glomerular filtration rate (GFR) of 61 patients with type 2 diabetes mellitus with renal scanning 99mTc-DTPA glomerular filtration rate at the hospital 175. Objective: (1) To study characteristics of imaging of renal function. (2) Understanding the relationship between GFR with blood sugar, HbA1c, blood pressure and albuminuria in patients with type 2 diabetes. Methods: Descriptive, prospective, cross-sectional study. Clinical examination, Clinical tests and 99mTc-DTPA GFR gamma - camera renography for patients. Result: GFR of the study group was 75,4 ± 22,3 ml/phut/1,73m2, the left kidney was 35,0 ± 13,0 is lower than the right kidney and 39,8 ± 11,9; p <0,01. There is no correlation between GFR with blood glucose and HbA1c, the risk of reduced GFR in hypertensive group associated is OR = 6,5 with p<0,01; albuminuria (+) is OR = 4,2 with p <0,01; and disease duration > 10 years is OR = 3,5 with p <0.01. Conclusion: GFR of the left kidneys is lower than the right kidney; correlation decreased GFR associated with hypertension, albuminuria and disease duration. Keywords: GFR, diabetes, albuminuria

Insulin Resistance, Elevated Glomerular Filtration Fraction, and Renal Injury

Hypertension ◽  
1996 ◽  
Vol 28 (1) ◽  
pp. 127-132 ◽  
Author(s):  
Donald R. Dengel ◽  
Andrew P. Goldberg ◽  
Ronaldo S. Mayuga ◽  
Gretchen M. Kairis ◽  
Matthew R. Weir
Keyword(s):  
Insulin Resistance ◽  
Glomerular Filtration ◽  
Renal Injury ◽  
Filtration Fraction

scholarly journals The Long-Term Effect of Preterm Birth on Renal Function: A Meta-Analysis

2021 ◽  
Vol 18 (6) ◽  
pp. 2951
Author(s):  
Ju Sun Heo ◽  
Jiwon M. Lee
Keyword(s):  
Renal Function ◽  
Preterm Birth ◽  
Glomerular Filtration ◽  
Renal Plasma Flow ◽  
Meta Analysis ◽  
Full Term ◽  
Significant Difference ◽  
Preterm Group ◽  
Preterm Born

The preterm-born adult population is ever increasing following improved survival rates of premature births. We conducted a meta-analysis to investigate long-term effects of preterm birth on renal function in preterm-born survivors. We searched PubMed and EMBASE to identify studies that compared renal function in preterm-born survivors and full-term-born controls, published until 2 February 2019. A random effects model with standardized mean difference (SMD) was used for meta-analyses. Heterogeneity of the studies was evaluated using Higgin’s I2 statistics. Risk of bias was assessed using the Newcastle–Ottawa quality assessment scale. Of a total of 24,388 articles screened, 27 articles were finally included. Compared to full-term-born controls, glomerular filtration rate and effective renal plasma flow were significantly decreased in preterm survivors (SMD −0.54, 95% confidence interval (CI), −0.85 to −0.22, p = 0.0008; SMD −0.39, 95% CI, −0.74 to −0.04, p = 0.03, respectively). Length and volume of the kidneys were significantly decreased in the preterm group compared to the full-term controls (SMD −0.73, 95% CI, −1.04 to −0.41, p < 0.001; SMD −0.82, 95% CI, −1.05 to −0.60, p < 0.001, respectively). However, serum levels of blood urea nitrogen, creatinine, and cystatin C showed no significant difference. The urine microalbumin to creatinine ratio was significantly increased in the preterm group. Both systolic and diastolic blood pressures were also significantly elevated in the preterm group, although the plasma renin level did not differ. This meta-analysis demonstrates that preterm-born survivors may be subject to decreased glomerular filtration, increased albuminuria, decreased kidney size and volume, and hypertension even though their laboratory results may not yet deteriorate.

scholarly journals Assessing glomerular filtration rate in healthy adult potential kidney donors in Bangladesh: A comparison of various prediction equations with measured glomerular filtration rate by diethylentriamine pentaacetic acid renogram

2014 ◽  
Vol 39 (2) ◽  
pp. 74-79
Author(s):  
F Jahan ◽  
MNU Chowdhury ◽  
T Mahbub ◽  
SM Arafat ◽  
S Jahan ◽  
...  
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Healthy Adult ◽  
Healthy Population ◽  
Prediction Equations ◽  
Estimated Gfr ◽  
Kidney Donors ◽  
Measured Gfr

To ensure that potential kidney donors in Bangladesh have no renal impairment, it is extremely important to have accurate methods for evaluating the glomerular filtration rate (GFR). We evaluated the performance of serum creatinine based GFR in healthy adult potential kidney donors in Bangladesh to compare GFR determined by DTPA with that determined by various prediction equations. In this study GFR in 61 healthy adult potential kidney donors were measured with 99mTc-diethylenetriamine penta-acetic acid (DTPA) renogram. We also estimated GFR using a four variable equation modification of diet in renal disease (MDRD), Cockcroft-Gault creatinine clearance (CG CrCl), Cockcroft-Gault glomerular filtration rate (CG-GFR). The mean age of study population was 34.31±9.46 years and out of them 65.6% was male. In this study mean mGFR was 85.4±14.8. Correlation of estimated GFR calculated by CG-CrCl, CG-GFR and MDRD were done with measured GFR DTPA using quartile. Kappa values were also estimated which was found to be 0.104 for (p=0.151), 0.336 for (p=0.001) and 0.125 for (p=0.091) respectively. This indicates there is no association between estimated GFR calculated by CG-CrCl, CG-GFR, MDRD with measured GFR DTPA. These results show poor performance of these equations in evaluation of renal function among healthy population and also raise question regarding validity of these equations for assessment of renal function in chronic kidney disease in our population. DOI: http://dx.doi.org/10.3329/bmrcb.v39i2.19646 Bangladesh Med Res Counc Bull 2013; 39: 74-79

Pathogenesis and Assessment of Renal Function in Patients With Liver Cirrhosis

Folia Medica ◽  
2012 ◽  
Vol 54 (4) ◽  
pp. 5-13 ◽  
Author(s):  
Bilyana H. Teneva
Keyword(s):  
Renal Function ◽  
Liver Cirrhosis ◽  
Glomerular Filtration Rate ◽  
Serum Creatinine ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Serum Markers ◽  
Meld Score ◽  
Kidney Damage ◽  
Early Assessment

Abstract In liver cirrhosis patients awaiting liver transplantation, it is prognostically equally important to assess the renal function before and after transplantation. This is evidenced by the inclusion of serum creatinine in the Model for End-Stage Liver Disease (MELD) score. Most of the causes of renal failure in liver cirrhosis are functional, the acute kidney damage including prerenal azotemia, acute tubular necrosis and hepatorenal syndrome. A major index of the renal function, the glomerular filtration rate (GFR) is determined in a specific way in patients with liver cirrhosis. Clinically, serum creatinine is considered the best indicator of kidney function, although it is rather unreliable when it comes to early assessment of renal dysfunction. Most of the patients with liver cirrhosis have several concomitant conditions, which are the reason for the false low creatinine levels, even in the presence of moderate to severe kidney damage. This also holds for the creatinine clearance and creatinine-based estimation equations for assessment of the glomerular filtration rate (the Cockroft-Gault and MDRD formulas), which overestimate the real glomerular filtration. Clearance of exogenous markers is considered a gold standard, but the methods for their determination are rather costly and hard to apply. Alternative serum markers (e.g., cystatin C) have been used, but they should be better studied in cases of liver cirrhosis assessment.

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