scholarly journals Kimura Disease of the Nose

2021 ◽  
Vol 6 (2) ◽  
pp. 61-64
Author(s):  
Zalilah Musa ◽  
Abdul Razak Ismail ◽  
Irfan Mohamad
Keyword(s):  
Head And Neck ◽  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Surgical Excision ◽  
Unknown Etiology ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Nasal Bridge ◽  
Chronic Inflammatory Disorder

Introduction: Kimura disease is a rare chronic inflammatory disorder affecting the subcutaneous tissue. It is of unknown etiology mainly occurring in head and neck region. Case report: A 34-year-old Malay lady presented with a gradually enlarging, painless right nasal bridge mass for one year duration. Clinical examination revealed a firm, immobile swelling measuring 2 cm x 2 cm. Nasal endoscopy showed no extension of the mass into the right nasal cavity. Surgical excision was performed where histopathological examination reported as finding consistent with Kimura disease. Conclusion: Kimura disease is extremely a rare benign disease, which can affect the head and neck structures. Manifestation at the nasal region is an extremely rare occurrence. Histopathological examination is needed to diagnose the disease.

scholarly journals Kimura disease of the supraauricular region: a rare presentation

2019 ◽  
Vol 5 (5) ◽  
pp. 1437
Author(s):  
Firamir Bin Zulkifli ◽  
Mawaddah Binti Azman ◽  
Loong Siow Ping
Keyword(s):  
Subcutaneous Tissue ◽  
Treatment Options ◽  
Neck Region ◽  
Surgical Excision ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Rare Presentation ◽  
High Tendency ◽  
Chronic Inflammatory Disorder ◽  
Benign Nature

Kimura disease is an idiopathic chronic inflammatory disorder involving the subcutaneous tissue. It favors the head and neck region, although presentation over atypical sites has been reported. This disease occurs spontaneously, has a characteristic indolent growth pattern but has a high tendency to recur locally after treatment. Due to its benign nature, there is still no clear consensus on the optimal management of this rare disorder. Various treatment options are available which include systemic steroids, antihistamines, immunosuppressant, chemotherapy, radiotherapy, and surgical excision. Presently, the disease remains a therapeutic enigma as the pathogenesis is still a mystery and its tendency to recur following treatment proves to be discouraging. Herein we report a rare case of Kimura disease involving the supra-auricular region who underwent surgical excision.

scholarly journals Kimura Disease as a Rare Cause of Proptosis: A Case Report

2021 ◽  
Vol 16 (2) ◽  
pp. 259-265
Author(s):  
V Sha Kri Eh Dam ◽  
Irfan Mohamad ◽  
Evelyn Li Min Tai ◽  
Adil Hussein ◽  
Khairil Amir Sayuti ◽  
...  
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Oral Prednisolone ◽  
Lymph Node Involvement ◽  
High Recurrence Rate ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
Middle Aged Adult

Kimura disease (KD) is a rare chronic inflammatory disorder of unknown aetiology that primarily affects the head and neck region with lymph node involvement. Young to middle-aged adult Asian males are predominantly affected. The most common presentation is painless subcutaneous swelling in the head and neck region, while proptosis or orbital involvement is very rarely reported. KD shares some features with other inflammatory and neoplastic disorders, including lymphoma; thus, investigations to confirm the diagnosis should not be delayed. Systemic corticosteroids are commonly used to treat KD and show an excellent response; however, the optimal treatment is still uncertain, and KD has a high recurrence rate. We describe the case of a patient with KD who presented with proptosis and post-auricular swelling, which responded well to oral prednisolone treatment.

Oropharyngeal Kimura’s disease: a diagnostic dilemma and therapeutic challenge

2020 ◽  
Vol 13 (10) ◽  
pp. e236366
Author(s):  
Prasanna Kumar Saravanam ◽  
Aishwarya Gajendran ◽  
Nethra Dinakaran ◽  
Dhaarani Jayaraman
Keyword(s):  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Treatment Modalities ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
First Line ◽  
Diagnostic Dilemma ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder

Kimura’s disease is a chronic inflammatory disorder involving subcutaneous tissue and locoregional lymph nodes of head and neck region, characterised by angiolymphoid proliferation. It is typically associated with peripheral eosinophilia, increased serum IgE and lymphadenopathy. Diagnosis is usually based on histopathological examination. Though various treatment modalities have been put forward, surgical management remains the first line of treatment, followed by systemic steroids application. This case report discusses the diagnostic dilemma and therapeutic management of a rare clinical presentation and management of oropharyngeal Kimura’s disease in a young immunocompetent woman.

Kimura Disease

2007 ◽  
Vol 131 (4) ◽  
pp. 650-651
Author(s):  
Mohammad Abuel-Haija ◽  
Matthew T. Hurford
Keyword(s):  
Immunoglobulin E ◽  
Subcutaneous Tissue ◽  
Elevated Serum ◽  
Unknown Etiology ◽  
Systemic Steroid ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Systemic Steroid Therapy ◽  
Peripheral Blood Eosinophilia

Abstract Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissue of the head and neck regions. Elevated serum immunoglobulin E levels and peripheral blood eosinophilia are also common. This disease is most common in middle-aged Asian men. Although the etiology is unknown, it most probably represents an aberrant chronic immune response. Treatment for Kimura disease includes surgical resection and regional or systemic steroid therapy. Cytotoxic therapy and radiation have also been utilized. The disease has an excellent prognosis, although it may recur locally.

scholarly journals Rituximab Treatment in a Patient with Kimura Disease and Membranous Nephropathy: Case Report

2021 ◽  
pp. 116-123
Author(s):  
Roald Vissing-Uhre ◽  
Alastair Hansen ◽  
Susanne Frevert ◽  
Ditte Hansen
Keyword(s):  
Case Report ◽  
Membranous Nephropathy ◽  
Neck Region ◽  
Renal Diseases ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Eosinophil Granulocytes ◽  
Anti Cd20

Kimura disease (KD) is a chronic, inflammatory disorder with slowly developing subcutaneous tumor-like swellings, often occurring in the head and neck region. KD is diagnosed based on histology, elevated levels of immunoglobulin type E, and increased peripheral eosinophil granulocytes. KD may coexist with glomerular renal diseases, and this case report is based on a patient with KD-associated membranous nephropathy. Patients with membranous nephropathy without KD have demonstrated responsiveness to treatment with monoclonal anti-CD20 antibodies. This case report is the first to investigate the effect of rituximab treatment in a patient with KD-associated membranous nephropathy. A 30-year-old Italian man living in Denmark was diagnosed with Kimura’s disease based on subcutaneous nodules with eosinophil angiolymphoid hyperplasia. The patient was admitted to the hospital due to nephrotic syndrome. Serology showed eosinophil granulocytosis and negative PLA2-receptor antibody. Renal biopsy showed membranous nephropathy, and the patient was treated with systemic methylprednisolone followed by cyclosporin and then cyclophosphamide with only partial remission. Ultimately, treatment with intravenous rituximab was initiated, which resulted in overall remission and no nephrotic relapses at 30 months of follow-up. Thus, intravenous rituximab effectively decreased proteinuria and prevented nephrotic relapses in a patient with treatment-refractory membranous nephropathy due to KD.

scholarly journals Rosai-Dorfman Disease Originating from Nasal Septal Mucosa

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Abdulvahap Akyigit ◽  
Hadice Akyol ◽  
Oner Sakallioglu ◽  
Cahit Polat ◽  
Erol Keles ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Head And Neck ◽  
Nasal Obstruction ◽  
Histopathological Examination ◽  
Neck Region ◽  
Unknown Etiology ◽  
Extranodal Involvement ◽  
Head And Neck Region ◽  
Histiocytic Cell ◽  
Rosai Dorfman Disease

Rosai-Dorfman disease is a rarely seen disease with unknown etiology. Extranodal involvement is most commonly seen in the head and neck region. Histopathologically, it is characterized by histiocytic cell proliferation. This paper presents a case of a 15-year-old male patient who presented with nasal obstruction and was surgically treated for a mass filling in the left nasal meatus that was diagnosed to be Rosai-Dorfman disease by histopathological examination.

scholarly journals Kimura Disease of the Parotid Gland: Management Approach

2022 ◽  
Vol 4 (1) ◽  
pp. 01-03
Author(s):  
Hafeza MS ◽  
Vanitha Palanisamy
Keyword(s):  
Parotid Gland ◽  
Frozen Section ◽  
Neck Region ◽  
Unknown Etiology ◽  
Management Approach ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Parotid Neoplasm ◽  
The Right

Here we present a 43-years old Malay man with Kimura’s disease of the right parotid gland. Asian men have a predisposition for this chronic inflammatory disorder of unknown etiology mostly presenting at the head and neck region. The management in dealing with this patient is not straight forward as the presentation mimics a subcutaneous tumor-like mass in which main differential diagnosis includes lymphoproliferative disorders and parotid neoplasm. Moreover, cytological investigation is inadequate, and this necessitates the use intra-operative frozen section prior to tumor debulking. Without proper investigation, misdiagnosis can occur and potentially expose the patient to unnecessary extensive surgical procedures. Here we discuss step by step approach in managing this patient.

scholarly journals A Clinical Characters and Prognosis Analysis on 15 Cases With Malignant Melanoma in the Head and Neck

2020 ◽  
Author(s):  
Xiaodong Liu ◽  
Weixian Liu ◽  
Qiuxu Wang
Keyword(s):  
Malignant Melanoma ◽  
Parotid Gland ◽  
Head And Neck ◽  
Histopathological Examination ◽  
Maxillofacial Surgery ◽  
Neck Region ◽  
Surgical Excision ◽  
Pathological Examination ◽  
Oral And Maxillofacial Surgery ◽  
Golden Standard

Abstract Objective: We analyze the pathogenesis, clinical characteristics, diagnosis, treatment and histological feature of Malignant Melanoma in the head and neck. To improve the understanding and help the early diagnosis and treatment of the disease. As a result, improve the treatment and prognosis of Malignant Melanoma in head and neck.Method: We collect 15 cases of Malignant Melanoma in the head and neck region treated in the Department of Oral and Maxillofacial Surgery in Shengjing Hospital of China Medical University. All data were obtained from patient’s medical records which including the pathogenesis, clinical and histological features, diagnosis, treatment and prognosis.Result: This study included 15 cases, there are 9 male and 6 female patients. The average age is 62.9 years lid, the oldest one is 75 years old and the youngest one is 40 years old. 2 cases occurred in the lip, 2 cases occurred in the tongue, 2 cases occurred in the submandibular area, 1 cases occurred in the parotid gland, 1 case occurred in the neck, other 7 cases occurred in the gingiva. The cases occurred in the lip, gingiva, tongue, parotid gland and submandibular area are primary tumor, cases occurred in neck were metastasis. 6 cases were treated by surgical excision. 1 cases occurred in gingiva was treated by surgical excision combine with chemotherapy. 5 years followed up has been taken. 10 cases were dead because of recurrence and metastasis in 5 years after the operation. 5 patients do not have a relapse and still alive.Conclusion: Malignant Melanoma in the head and neck are mostly affected the old people. In this study gingiva is the most commonly primary site, neck is the most commonly transferring site. The diagnosis of malignant Melanoma is mainly relying on the clinical manifestation and pathological examination. Histopathological examination is considered the golden standard for diagnosis. Surgical excision combined with chemotherapy is the main treatment modality for Malignant Melanoma. Cryotherapy and immunotherapy also have been used in the treatment. The prognosis of Malignant Melanoma is poor. So early detection and early treatment is important in the treatment.

Our Experience in Treating a Rare Clinical Case Angiomyomatous Hamartomas of Head and Neck Region; Case Report

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Hakobyan Gagik
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Surgical Excision ◽  
Final Diagnosis ◽  
External Carotid Artery ◽  
Unknown Etiology ◽  
External Carotid ◽  
Head And Neck Region ◽  
Neck Masses ◽  
Head And Neck Masses

Angiomyomatous hamartoma of head and neck region is very are disease, of unknown etiology and more often than not it can be misdiagnosed preoperatively. Materials and Methods: In a study we present a case of angiomyomatous hamartoma in the carotid triangle, a site where a tumor has an invasion to external carotid artery, treatment carried out by surgical excision, after histological examination, the final diagnosis was made. The patient was under observation for 3 years, there were no relapses. Conclusion: The diagnosis of angiomyomatous hamartoma is based on histologic examination. Although this entity is rare, we believe that head and neck surgeons should include it in the differential diagnosis of head and neck masses.

scholarly journals Malakoplakia of the parotid gland: a case report and review of localised malakoplakia of the head and neck

2019 ◽  
Vol 101 (5) ◽  
pp. 309-312
Author(s):  
C Samian ◽  
S Ghaffar ◽  
V Nandapalan ◽  
S Santosh
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Head And Neck ◽  
World Literature ◽  
Neck Region ◽  
Submandibular Salivary Gland ◽  
Inflammatory Disorder ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder

Introduction Malakoplakia is a rare chronic inflammatory disorder, predominantly affecting the urinary tract. In the head and neck region, it is very rare and may confuse the clinicians during investigations, as features may mimic malignancy. Materials and methods We report a case of malakoplakia involving the parotid gland and review of the reported cases of malakoplakia in head and neck region. Results Histologically, this is the first classic case report of malakoplakia involving the parotid gland in the world literature. A total of 49 cases have been reported in the head and neck region; 38.7% of these are cutaneous. In soft tissue, the tongue is the most common site. Salivary gland involvement is very rare. Previously, submandibular salivary gland involvement has been reported. Conclusion A possibility of malakoplakia should be considered as a differential diagnosis in patients with enlarged head and neck masses. Histology is essential to diagnose this benign inflammatory disorder and to differentiate from a malignant process.

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