scholarly journals PROFIL PASIEN KO-INFEKSI TUBERCULOSE-HIV DI RSUD DOK II JAYAPURA Tuberculosis-HIV Co-infection Profile in DOK II Hospital Jayapura

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Elfride Irawati Sianturi ◽  
Rusnaeni Rusnaeni
Keyword(s):  
Side Effects ◽  
Drug Monitoring ◽  
Clinical Symptoms ◽  
Fixed Dose ◽  
Her Family ◽  
Monitoring Therapy ◽  
Common Opportunistic Infection ◽  
Dose Combination ◽  
Keywords Aids ◽  
Hiv Aids

AbstrakPapua adalah daerah yang memiliki angka prevalensi HIV-AIDS tertinggi di Indonesia. Infeksi TB adalah infeksi oportunistik terbanyak yang menyerang pasien HIV-AIDS.  Tujuan penelitian ini adalah untuk mengetahui profil pasien koinfeksi TB-HIV yang mendapatkan pengobatan obat anti tuberculosis (OAT) di klinik VCT RSUD Dok II Jayapura selama periode Januari 2011 hingga September 2012. Penelitian ini merupakan penelitian retrospektif deskriptif. Data diambil dari rekam medik, kartu TB 01 dan hasil mikrobiologis pasien koinfeksi TB-HIV yang mengambil OAT di  klinik VCT RSUD Dok II Jayapura. Hasil penelitian menunjukkan bahwa 35 dari 124 pasien adalah pasien default yang mengalami efek samping obat dan tidak memiliki Pengawas Minum Obat (PMO). Efek samping obat TB menjadi kendala selama pengobatan sehingga peranan PMO yang berasal dari keluarga inti mampu membantu pasien menyelesaikan pengobatan TB tersebut. Kata kunci: AIDS, pengawas minum obat (PMO), rifampisin, tuberculosis, AbstractPapua shows the highest prevalency rate of HIV-AIDS in Indonesia and almost 60% people who live with HIV develop tuberculosis (TB), hence TB is the most common opportunistic infection in HIV patients. This study was aimed to know and to describe the profile of TB-HIV co-infection patients among TB patients according to clinical symptoms and the side effects of FDC (Fixed Dose Combination) drugs. Methods used was descriptive study taken from medical record of 124  TB-HIV co-infection patients in Dok II Jayapura hospital, Papua during January  2011 – September 2012. Results showed that 35 of 124 patients indicated side effect of antituberculosis risk default when they did not undergo drug monitoring therapy. The patients should be controlled by his/her family to help them through all the side effects of antituberculose drugs to complete the treatment. Keywords: AIDS, drug monitoring therapy, rifampicin, tuberculosis

scholarly journals Association between Compliance Level on Fixed-Dose Combination Antiretroviral Drug and CD4 Level among HIV Patients

2020 ◽  
Author(s):  
Fadhil Ilham Mustafa ◽  
◽  
Nurfitri Bustamam ◽  
Andri Pramesyanti ◽  
◽  
...  
Keyword(s):  
Significant Relationship ◽  
Fixed Dose Combination ◽  
Hiv Care ◽  
Fixed Dose ◽  
People Living With Hiv ◽  
Hiv Patients ◽  
Drug Induced ◽  
Cross Sectional ◽  
Dose Combination ◽  
Hiv Aids

Background: People living with HIV / AIDS (PLWHA) have weak immune systems and are prone to infection. Therefore, PLWHA must take antiretroviral (ARV) to maintain their immunity. This study aimed to determine the relationship between the level of adherence to taking ARV fixed-dose combination (FDC) drugs and CD4 levels of HIV patients. Subjects and Method: This was a cross-sectional study conducted at Pengayoman Cipinang Hospital, Indonesia, in 2018. Total of 91 HIV patient over 17 years of age, had or had received FDC ARV therapy for at least 1 year, and did not experience drug-induced hepatitis were enrolled in this study. The dependent variable was CD4 level. The independent variable was level of adherence to taking ARV fixed-dose combination (FDC). The data were taken from the Voluntary Counseling and Testing Poli Pengayoman Cipinang Hospital. This study used secondary data from the Overview of HIV Care and ARV Therapy. The data were analyzed using Chi-square. Results: A total of 65.93% HIV patients had a good level of medication adherence and 79.12% had an increase of CD4 levels. There was a significant relationship between adherence to taking FDC ARV drugs and CD4 levels (OR = 6.50; 95% CI = 2.15 to 19.62; p<0.001), and it was statistically significant. Conclusion: There is a significant relationship between the level of adherence to taking FDC ARV drugs and CD4 levels. Therefore, patients must receive education and support to improve adherence to taking ARV drugs. Keywords: antiretroviral, CD4, fixed-dose combination, adherence to taking medication, people with HIV / AIDS Correspondence: Fadhil Ilham Mustafa. Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta. Jl. RS Fatmawati, Pondok Labu, South Jakarta. Email: [email protected]. Mobile: 081283681755. DOI: https://doi.org/10.26911/the7thicph.02.03

scholarly journals Combination of Tramadol-Paracetamol in Palliative Care Pain Management: A Case Report

2021 ◽  
Vol 3 (1) ◽  
pp. 39
Author(s):  
Riris Sifa Fauziah
Keyword(s):  
Palliative Care ◽  
Case Report ◽  
Side Effects ◽  
Opioid Analgesic ◽  
Palliative Therapy ◽  
Spinal Pain ◽  
Fixed Dose ◽  
Vas Score ◽  
Before And After ◽  
Dose Combination

One of the basic goals of palliative care is to reduce the suffering of the patient, which includes relieving the pain. Some facts show that sometimes a doctor is afraid to give opioid analgesic mono-therapy to his patients because she is worried on one hand about the effect of addiction. In addition, in some cases, NSAID analgesics mono-therapy can also cause a series of side effects or even the patient may be contraindicated against the use of NSAID or paracetamol class drugs. Actually, this can be prevented by giving a combination of opioids and non-opioids analgesic. By providing this combination of therapy, it is hoped that this can accelerate the onset of work, extend the working period which can reduce the dose of drugs consumed, and more importantly minimize the side effects of each drug. The fixed dose combination of Tramadol-Paracetamol (Tramadol 37.5 mg–Paracetamol 325 mg) is an example of a drug combination preparation that has been shown to be effective in the treatment of pain. In this case report, a patient who is currently undergoing palliative therapy for cancer is described. On the way, the patient felt spinal pain as a result of the spread of the disease. The combination of Tramadol-paracetamol was administered twice a day with a dose that adjusted to the VAS Score observations before and after drug administration. And in this case, there was a decrease in the VAS score after being given Tramadol-Paracetamol combination.

Testosterone treatment of clinical hypogonadism in patients with HIV/AIDS

1997 ◽  
Vol 8 (9) ◽  
pp. 537-545 ◽  
Author(s):  
Judith G Rabkin ◽  
Richard Rabkin ◽  
Glenn J Wagner
Keyword(s):  
Side Effects ◽  
Outcome Measures ◽  
Clinical Application ◽  
Clinical Management ◽  
Clinical Symptoms ◽  
Testosterone Therapy ◽  
Testosterone Treatment ◽  
Measurement Issues ◽  
Treatment Indications ◽  
Hiv Aids

The use of testosterone to treat clinical symptoms of hypogonadism and wasting among patients with HIV/AIDS is a relatively new area of inquiry and clinical application. Outcome measures have included changes in mood, libido, energy, weight and muscle mass1-5. The purpose of this review is to identify the questions most commonly raised about risks of testosterone therapy, to review available data which address these questions, and to discuss issues of clinical management. These include treatment indications, measurement issues, and side effects and their management.

scholarly journals Fixed-dose combination and therapeutic drug monitoring in tuberculosis: friend or foe?

2016 ◽  
Vol 48 (4) ◽  
pp. 1230-1233 ◽  
Author(s):  
Marlanka A. Zuur ◽  
Onno W. Akkerman ◽  
Lina Davies Forsman ◽  
Yi Hu ◽  
Rongdong Zheng ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Therapeutic Drug ◽  
Dose Combination

scholarly journals Potential side effects of medicine on patients with tuberculosis fixed-dose combination in dr. Pirngadi Hospital, Medan

2020 ◽  
Vol 20 (1) ◽  
pp. 10-14
Author(s):  
EVA SARTIKA DASOPANG ◽  
FENNY HASANAH ◽  
IDA FAUZIAH ◽  
SALMAN SALMAN ◽  
TEDY KURNIAWAN BAKRI
Keyword(s):  
Side Effects ◽  
Compliance Rate ◽  
Acute Stage ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Tb Treatment ◽  
Stomach Pain ◽  
Patient Will ◽  
New Antibiotics ◽  
Dose Combination

Tuberculosis is caused by the bacterium Mycobacterium tuberculosis, which by only using a few new antibiotics, can kill the bacteria. Tuberculosis treatment has several stages, namely intensive and advanced stages. Compliance with the use of OAT is an imported factor in the success of TB treatment. The use of many drugs can cause side effects that result in patients stopping treatment when it creates the TB treatment process to fail. Improved adherence can do by using a fixed-dose combination OAT. In the intensive phase, the patient will get a fixed-dose combination containing a mixture of four antibiotics. The purpose of this study is to evaluate the potential side effects that occur during fixed-dose combination OAT treatment at an intensive stage and see the level of compliance of patients taking TB drugs. Observational sampling in TB patients was taking OAT at an acute stage by looking at side effects that arise during treatment and then analyzed using statistics and algorithm Naranjo. The results showed the most common potential side effects for fixed-dose combination OAT in the intensive stage were itching, headache and nausea with a percentage of 72% each, joint pain 45%, stomach pain 36.4%, lack of appetite and rashes 27.3% each and reddish color in the urine 18.2%. The results of the analysis using Naranjo logarithm obtained results eight, which means the side effects might cause due to the use of the drug. The results of patient compliance achieved a 100% compliance rate

scholarly journals Studi Efektifitas Antiretroviral Regimen Obat Kombinasi Dosis Tetap (Tenofovir/Lamivudin/Efavirenz) Berdasarkan Peningkatan Kadar Cd4 T-Limfosit (Studi dilakukan di Intalasi Farmasi Rumah Sakit X Surabaya)

2018 ◽  
Vol 2 (1) ◽  
pp. 22-28
Author(s):  
Putri Kusuma Wardani ◽  
Ninik Mas Ulfa ◽  
A.C Aditya Natalia
Keyword(s):  
Immune Deficiency ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Dose Combination ◽  
Cluster Of Differentiation ◽  
Acquired Immune Deficiency ◽  
Hiv Aids

ABSTRAKHIV adalah virus yang secara bertahap menyerang sistem kekebalan tubuh manusia. HIV dapat menyebabkan AIDS (Acquired Immune Deficiency Syndrome) dan sel yang terinfeksi yang memiliki molekul Cluster of Differentiation 4 (CD4). Pengobatan dengan antiretroviral memiliki mekanisme tindakan untuk mencegah replikasi virus yang secara bertahap menurunkan jumlah virus dalam darah. Penelitian ini observasional yang dilakukan secara retrospektif selama 2 tahun (Januari 2014 - Desember 2015) pada pasien HIV / AIDS denganjumlah 51 pasien rawat jalan. Hasil studi observasional menunjukkan bahwa pengobatan dengan antiretroviral regimen obat kombinasi dosis tetap (Tenofovir 300 mg + Lamivudin 300 mg + Efavirenz 600 mg) mengalami peningkatan jumlah CD4 selama terapi dan analisis statistik deskriptif menunjukkan bahwa ada perbedaansebelum dan sesudah terapi, sehingga dapat disimpulkan bahwa antiretroviral regimen obat kombinasi dosis tetap efektif.Kata Kunci: HIV / AIDS, CD4 T-Limfosit, Tenofovir, Lamivudin, Efavirenz.ABSTRACTHIV is a virus that gradually attack the human immune system. HIV can lead to the AIDS (Acquired Immune Deficiency Syndrome) and infected cells that have molecul Cluster of Differentiation 4 (CD4). Treatment withantiretroviral have mechanism of action to prevent replication virus which is step by step decrease the amount of virus in blood. This observasional study conducted retrospectively during 2 years (Januari 2014 - December2015) againt patient HIV/AIDS with 51 outpatients. The result of the observational study showed that treatment with Antiretroviral Fixed Dose Combination (Tenofovir 300 mg + Lamivudin 300 mg + Efavirenz 600 mg) had increased CD4 level during therapy and descriptive statistic analysis showed that there was a differences in preand post theraphy, so if could be concluded that Antiretroviral Fixed Dose Combination administration was effective.Key Words: HIV/AIDS, CD4 T-Limfosit, Tenofovir, Lamivudin, Efavirenz.

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