Helicobacter pylori – a still ongoing problem

2020 ◽  
Vol 13 (4) ◽  
pp. 491-495
Author(s):  
Leszek Paradowski

The diagnosis and treatment of Helicobacter pylori infection are up-to-date, which is due to the frequency of human infections and the consequences of the chronic once, in most cases Helicobacter pylori infection is asymptomatic. If there are symptoms, the most common are dyspeptic complaints. In some patients Helicobacter pylori causes severe disease, mainly in stomach. This pathogen has been recognized as the main cause of the peptic ulcer, gastric cancer and MALT lymphoma. It is also known to play an important role in some other disease such essential thrombocytopenia, some types of deficiency anemia. This article discusses the current on the epidemiology of Helicobacter pylori infection, its consequences, diagnosis, treatment and the prevention of infection, information on changes in flora of digestive tract that can occur during the eradication of this bacterium, is also presented.

2005 ◽  
Vol 29 (9) ◽  
pp. 1127-1130 ◽  
Author(s):  
Andrea Giuliani ◽  
Alessandro Caporale ◽  
Martino Demoro ◽  
Eugenio Benvenuto ◽  
Massimo Scarpini ◽  
...  

1995 ◽  
Vol 62 (4) ◽  
pp. 313-319
Author(s):  
Norio Matsukura ◽  
Masahiko Onda ◽  
Kiyohiko Yamashita

2006 ◽  
Vol 50 (7) ◽  
pp. 2550-2552 ◽  
Author(s):  
P. Ruggiero ◽  
F. Tombola ◽  
G. Rossi ◽  
L. Pancotto ◽  
L. Lauretti ◽  
...  

ABSTRACT Helicobacter pylori colonizes the human gastric mucosa, causing inflammation that leads to atrophic gastritis, and it can cause peptic ulcer and gastric cancer. We show that polyphenol administration to mice experimentally infected by H. pylori or treated with VacA toxin can limit gastric epithelium damage, an effect that may be linked to VacA inhibition.


2004 ◽  
Vol 132 (11-12) ◽  
pp. 458-462 ◽  
Author(s):  
Aleksandra Sokic-Milutinovic ◽  
Vera Todorovic ◽  
Tomica Milosavljevic

Clinical relevance of infection with different Helicobacter pylori strains was reviewed in this paper. Helicobacter pylori (H. pylori) infection plays a role in pathogenesis of chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. Extragastric manifestations of H. pylori infection most probably include acne rosacea and chronic urticaria, while the importance of H. pylori infection for pathogenesis of growth retardation in children, iron deficiency anemia, coronary heart disease, stroke and idiopathic thrombocytopenic purpura remains vague. The expression of two H. pylori proteins, cytotoxin associated protein (cag A) and vacuolization cytotoxin (vac A) is considered to be related with pathogenicity of the bacterium. It is clear that presence of cag A+ strains is important for development of peptic ulcer; nevertheless, it is also protective against esophageal reflux disease. On the other hand, cag A+ strains are common in gastric adenocarcinoma and MALT lymphoma patients, but it seems that certain subtypes of vac A cytotoxin are more important risk factors. Infection with cag A+ strains is more common in patients with acne rosacea, stroke and coronary heart disease.


Life Sciences ◽  
2008 ◽  
Vol 83 (7-8) ◽  
pp. 301-304 ◽  
Author(s):  
Mitsushige Sugimoto ◽  
Takahisa Furuta ◽  
Naohito Shirai ◽  
Chise Kodaira ◽  
Masafumi Nishino ◽  
...  

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