scholarly journals DIFFERENCES OF VITAMIN D LEVELS IN CONTROLLED AND UNCONTROLLED TYPE 2 DIABETES MELLITUS ( DM ) PATIENTS

Author(s):  
Adhisti Adhisti Azlin ◽  
Ratna Akbari Ganie ◽  
Santi Syafril

Vitamin D as an immunomodulator, plays an important role in controlling glycemic levels and decreasing diabetes complications. HbA1c is a marker of glycemic control which is known to have association with vitamin D. This study aims to see the differences in vitamin D serum levels and glycemic index in patients with type 2 DM.The design of this study is cross-sectional study and it was performed in RSUP HAM in December 2017 until March 2018. DM type 2 patients were classified based on HbA1c <7% controlled and ≥ 7% uncontrolled. Vitamin D serum levels were examined using the Enzyme-Linked Fluourescent Assay (ELFA) method., differences in vitamin D levels among controlled and uncontrolled type 2 diabetes mellitus were assessed by using independent t-test, and the differences of HbA1c level were assessed using Mann-Whitney-U test.45 patients with type 2 DM were divided into controlled (HbA1c <7%) and uncontrolled patients (HbA1c ≥ 7%). There was no difference in vitamin D serum levels between controlled and uncontrolled DM Type 2 patients (p = 0,310).

2021 ◽  
Vol 9 (1) ◽  
pp. 13-20
Author(s):  
Dr. J.V. Srujan ◽  
◽  
Dr. Surya Prakash Rao ◽  

Introduction: Diabetes is defined as a disturbance in intermediary metabolism manifesting aschronic sustained hyperglycemia, primarily due to either an absolute or a relative lack of insulin.Many epidemiological studies have demonstrated an inverse relationship between vitamin D levelsand diabetes mellitus. However, there is a paucity of literature regarding the levels of vitamin D intype 2 diabetes, which is common in our community. This study was taken up to shed more light onthis issue. Material and methods: This was a cross-sectional study conducted at NRI Institute ofMedical Sciences, Sangivalasa, Visakhapatnam district. Cases of Type 2 Diabetes Mellitus attendingto the outpatient department, diagnosed as per the ADA criteria of 2011, between the ages of 31and 75 years constituted the material for the present study. Results and conclusion: Vitamin Dlevels were found to be significantly lower in the study group (19.91±7.0 ng/ml) as compared to thecontrol group (32.22±4.0 ng/ml).


2014 ◽  
Vol 84 (1-2) ◽  
pp. 27-34 ◽  
Author(s):  
Nasser M. Al-Daghri ◽  
Khalid M. Alkharfy ◽  
Nasiruddin Khan ◽  
Hanan A. Alfawaz ◽  
Abdulrahman S. Al-Ajlan ◽  
...  

The aim of our study was to evaluate the effects of vitamin D supplementation on circulating levels of magnesium and selenium in patients with type 2 diabetes mellitus (T2DM). A total of 126 adult Saudi patients (55 men and 71 women, mean age 53.6 ± 10.7 years) with controlled T2DM were randomly recruited for the study. All subjects were given vitamin D3 tablets (2000 IU/day) for six months. Follow-up mean concentrations of serum 25-hydroxyvitamin D [25-(OH) vitamin D] significantly increased in both men (34.1 ± 12.4 to 57.8 ± 17.0 nmol/L) and women (35.7 ± 13.5 to 60.1 ± 18.5 nmol/L, p < 0.001), while levels of parathyroid hormone (PTH) decreased significantly in both men (1.6 ± 0.17 to 0.96 ± 0.10 pmol/L, p = 0.003) and women (1.6 ± 0.17 to 1.0 ± 0.14 pmol/L, p = 0.02). In addition, there was a significant increase in serum levels of selenium and magnesium in men and women (p-values < 0.001 and 0.04, respectively) after follow-up. In women, a significant correlation was observed between delta change (variables at six months-variable at baseline) of serum magnesium versus high-density lipoprotein (HDL)-cholesterol (r = 0.36, p = 0.006) and fasting glucose (r = - 0.33, p = 0.01). In men, there was a significant correlation between serum selenium and triglycerides (r = 0.32, p = 0.04). Vitamin D supplementation improves serum concentrations of magnesium and selenium in a gender-dependent manner, which in turn could affect several cardiometabolic parameters such as glucose and lipids.


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2393-PUB
Author(s):  
KENICHIRO TAKAHASHI ◽  
MINORI SHINODA ◽  
RIKA SAKAMOTO ◽  
JUN SUZUKI ◽  
TADASHI YAMAKAWA ◽  
...  

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