scholarly journals Preparation and Characterization of Spion-CDs as a Multifunctional Fluorescence/Magnetic Resonance Nanoparticle

2019 ◽  
Vol 27 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Mahdi Asgari ◽  
Hasan Motaghi ◽  
Hossein Khanahmad ◽  
Masoud A. Mehrgardi ◽  
Amin Farzadniya ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Properties ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Carbon Dots ◽  
Optimal Size ◽  
Resonance Imaging ◽  
Super Paramagnetic Iron Oxide ◽  
Fluorescence Characteristics ◽  
Multifunctional Nanoparticle

Abstract A multifunctional nanoparticle, Super Paramagnetic Iron Oxide Nanoparticle-Carbon Dots (SPION-CDs), for fluorescence and magnetic resonance imaging is introduced. This nanoparticle possesses the magnetic properties of super-paramagnetic iron oxide (SPION) core as well as the fluorescence characteristics of carbon dots (CDs) coated in mesoporous structure. The SPION-CDs were synthesized using a high temperature facile single-pot hydrothermal method. The products were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), UV/vis absorption, vibrating sample magnetometer (VSM). The cytotoxic effect of SPION-CDs on OVCAR-3 cells was also evaluated. The synthesized nanoparticle possesses optimal size, low toxicity and excellent magnetic properties, including super-paramagnetic behavior (Ms = 42 emu g−1). Moreover, in the viewpoint of optical properties, the quantum yield of ~2.4% was obtained and the nanoparticle shows good fluorescence stability for cell-labeling studies. This multifunctional nanoparticle with appropriate characterization is a promising candidate for multimodal fluorescence/magnetic resonance imaging platform.

Gold nanoclusters decorated with magnetic iron oxide nanoparticles for potential multimodal optical/magnetic resonance imaging

2015 ◽  
Vol 3 (23) ◽  
pp. 5910-5917 ◽  
Author(s):  
Chan Wang ◽  
Yagang Yao ◽  
Qijun Song
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Properties ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Cancer Diagnosis ◽  
Gold Nanoclusters ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Optical And Magnetic Properties

The dual optical and magnetic properties of the synthesized Fe3O4@AuNCs were applicable to cancer diagnosis by fluorescence and MR-based imaging.

scholarly journals Precise Study on Size-Dependent Properties of Magnetic Iron Oxide Nanoparticles for In Vivo Magnetic Resonance Imaging

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ling Chen ◽  
Jun Xie ◽  
Haoan Wu ◽  
Jianzhong Li ◽  
Zhiming Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Properties ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Magnetic Iron Oxide

Developing a biocompatible contrast agent with high stability and favorable magnetism for sensitive detection of malignant tumors using magnetic resonance imaging (MRI) remains a great demand in clinical. Nowadays, the fine control of magnetic iron oxide nanoparticle (MION) sizes from a few nanometers to dozens of nanometers can be realized through a thermal decomposition method of iron precursors. This progress allows us to research accurately on the size dependence of magnetic properties of MION, involving saturation magnetization (Ms), specific absorption rate (SAR), and relaxivity. Here, we synthesized MION in a size range between 14 and 26 nm and modified them with DSPE-PEG2000 for biomedical use. The magnetic properties of PEGylated MION increased monotonically with MION size, while the nonspecific uptake of MION also enhanced with size through cell experiments. The MION with the size of 22 nm as a T2-weighted contrast agent presented the best contrast-enhancing effect comparing with other sizes in vivo MRI of murine tumor. Therefore, the MION of 22 nm may have potential to serve as an ideal MRI contrast agent for tumor detection.

scholarly journals Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia

2016 ◽  
Vol 18 (25) ◽  
pp. 16848-16855 ◽  
Author(s):  
Maria F. Casula ◽  
Erika Conca ◽  
Ioanna Bakaimi ◽  
Ayyappan Sathya ◽  
Maria Elena Materia ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Properties ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Water Soluble ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Nanoparticle Clusters ◽  
Oxide Nanoparticle ◽  
Mn Doped

A method for water-soluble Mn doped iron oxide clusters and their magnetic properties.

scholarly journals Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents

2019 ◽  
Vol 10 ◽  
pp. 1964-1972 ◽  
Author(s):  
Natalia E Gervits ◽  
Andrey A Gippius ◽  
Alexey V Tkachev ◽  
Evgeniy I Demikhov ◽  
Sergey S Starchikov ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Properties ◽  
Iron Oxide ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Behavior ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

Background: One of the future applications of magnetic nanoparticles is the development of new iron-oxide-based magnetic resonance imaging (MRI) negative contrast agents, which are intended to improve the results of diagnostics and complement existing Gd-based contrast media. Results: Iron oxide nanoparticles designed for use as MRI contrast media are precisely examined by a variety of methods: powder X-ray diffraction (XRD), transmission electron microscopy (TEM), Raman spectroscopy, Mössbauer spectroscopy and zero-field nuclear magnetic resonance (ZF-NMR) spectroscopy. TEM and XRD measurements reveal a spherical shape of the nanoparticles with an average diameter of 5–8 nm and a cubic spinel-type crystal structure of space group Fd−3m. Raman, Mössbauer and NMR spectroscopy clearly indicate the presence of the maghemite γ-Fe2O3 phase. Moreover, a difference in the magnetic behavior of uncoated and human serum albumin coated iron oxide nanoparticles was observed by Mössbauer spectroscopy. Conclusion: This difference in magnetic behavior is explained by the influence of biofunctionalization on the magnetic and electronic properties of the iron oxide nanoparticles. The ZF-NMR spectra analysis allowed us to determine the relative amount of iron located in the core and the surface layer of the nanoparticles. The obtained results are important for understanding the structural and magnetic properties of iron oxide nanoparticles used as T 2 contrast agents for MRI.

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