scholarly journals Clinicopathological Study of Skin Adnexal Tumors: A Single Institute Experience

2021 ◽  
Vol 21 (2) ◽  
pp. 61-68
Author(s):  
V. Bartos
Keyword(s):  
Sweat Gland ◽  
Neck Region ◽  
Sebaceous Glands ◽  
Head And Neck Region ◽  
Clinicopathological Findings ◽  
Anatomic Distribution ◽  
Broad Variety ◽  
And Gender ◽  
Follicular Tumors ◽  
Adnexal Tumors

Abstract Background: Skin adnexal tumors (SATs) encompass a very broad variety of rare dermatopathologic entities. Objective: The aim of the present study was to analyze an incidence and clinicopathological findings of patients with biopsy-proven ASTs. Material and Methods: A retrospective review of all consecutive cutaneous tumors that were diagnosed at the Martin Biopsy Center in Martin from July 2019 to March 2021 was carried out. ASTs have been searched for from this file and studied based on their histologic type and line of differentiation, anatomic distribution, age, and gender. Results: Among over 3,700 skin tumors a total of 38 ASTs in 38 individuals (21 males, 17 females) have been found. The age of the patients ranged from 22-89 years (mean 55.5 y.). The head and neck region was found to be the most common site affected (26/38; 68.4%), followed by extremities (8/38; 21.1%) and trunk (4/38; 10.5%). Tumors of hair follicle origin constituted the largest category (22/38; 57.9%), followed by sweat gland tumors (15/38; 39.5%) and tumors derived from sebaceous glands (1/38; 2.6%). Benign lesions accounted for all 38 cases. Trichoepithelioma was the most frequent lesion found in the category of follicular tumors and poroma was the most common among tumours with sweat gland differentiation. Conclusion: An overall incidence of ASTs is low and in this institutional study they constituted about 1% of all cutaneous neoplasms. ASTs display a marked phenotypic heterogeneity, that is why many published studies have provided divergent results concerning their clinicopathological features.

scholarly journals Spectrum of skin adnexal tumors with eccrineand apocrine differentiation – A single institution study of 40 cases with clinicopathological correlation

2015 ◽  
Vol 5 (9) ◽  
pp. 727-732
Author(s):  
P Vijayan ◽  
R Nayak
Keyword(s):  
Correct Diagnosis ◽  
Neck Region ◽  
Skin Tumors ◽  
Benign Tumors ◽  
Head And Neck Region ◽  
Tertiary Center ◽  
Apocrine Differentiation ◽  
Diagnostic Difficulties ◽  
Adnexal Tumors

Background: Adnexal skin tumors are relatively rare and present diagnostic difficulties in view of the endless morphological spectrum, complex nomenclature and incomplete knowledge of their histogenesis. Since pathologists encounter these lesions rarely, accurate sub classification of these can be challenging. This study intends to study skin adnexal tumors with eccrine and apocrine differentiation with emphasis on their histomorphology.Materials and Methods:The present study is a five year retrospective study with comprehensive analysis of 40 cases of adnexal tumors of skin in a tertiary center in Karnataka, South India. These tumors were reclassified and subtyped according to WHO classification of skin tumors, 2006.Results and analysis:Out the 62 cases of adnexal tumors studied, 40 were tumors with eccrine and apocrine differentiation (77% benign and 23% malignant). Hidradenoma was the most common tumor comprising 37% of all tumors and 45% of the benign tumors followed byspiradenoma, cylindroma and chondroidsyringoma respectively. Head and neck region was the most common site of occurrence, and seventh decade was the most frequent age group of presentation. A definite female preponderance was noted. Pagets disease of the breast was the most common malignant tumor in this group comprising (10%). Conclusion: Histopathology is considered the gold standard in the diagnosis of these tumors and so a clear knowledge of the clinical presentation and histomorphology of these tumors is essential to make a correct diagnosis. A diagnostic logarithm based on histomorphology provides a logical approach in the subclassification of adnexal tumors.DOI:

Pilomatrixoma: a common tumour of head and neck, but rarely reported

2021 ◽  
Vol 14 (2) ◽  
pp. e238033
Author(s):  
Korikkar Mahaling Veena ◽  
Jagadish Chandra
Keyword(s):  
Differential Diagnosis ◽  
Head And Neck ◽  
Preoperative Diagnosis ◽  
Neck Region ◽  
Beta Catenin ◽  
Neck Swelling ◽  
Sebaceous Glands ◽  
Head And Neck Region ◽  
Skin Tumour ◽  
Ctnnb1 Gene

Pilomatrixoma is a benign subcutaneous tumour arising from the sebaceous glands. Mutation in the CTNNB1 gene is seen, suggesting beta-catenin misregulation may be the cause of pilomatrixoma. The preoperative diagnosis may be improved by the awareness of the fact that pilomatrixoma is a common and benign skin tumour of the head and neck region. It presents as a well-defined mass, which may be firm to hard in consistency, usually attached to the skin, but not to the underlying tissue. The colour of overlying skin appears a reddish-brown tinge, indicating that it could be a case of pilomatrixoma. Here, we report a case of pilomatrixoma of the cheek in a woman along with the CT findings and histopathological appearances. Dental surgeons should consider it as one of the differential diagnosis in superficial head and neck swelling with calcification.

Sebaceous carcinoma of the breast area − a case report

2021 ◽  
Vol 100 (4) ◽  
Keyword(s):  
Case Report ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Pectoral Muscle ◽  
Sebaceous Carcinoma ◽  
Sebaceous Glands ◽  
Head And Neck Region ◽  
Good Clinical Condition ◽  
Medical Teams ◽  
The Right

Introduction: Sebaceous carcinoma is a rare malignant tumor of the sebaceous glands. Sebaceous carcinoma occurs mainly in the head and neck region, rarely in trunk. Case report: We present a case report of 63-year-old patient, operated on for sebaceous carcinoma in the right breast area. The patient underwent radical surgery, removal of the tumor with the skin, subcutaneous tissue, and the large pectoral muscle. The patient is in good clinical condition eight months after the surgery. She is being constantly monitored and so far, there are neither signs of local recurrence nor tumor progression. Conclusion: Patients with rare tumors should be treated comprehensively with subsequent lifelong dispensarisation in specialized centers. Multidisciplinary medical teams are able to eruditely diagnose, recognize, treat and dispense patients.

scholarly journals Teratoid Cyst of the Postauricular Region: The First Ever Case Report

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Sabin Ranabhat ◽  
Mamata Tiwari ◽  
Sushna Maharjan
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Dermoid Cyst ◽  
Neck Region ◽  
The Body ◽  
Sebaceous Glands ◽  
Germ Layers ◽  
Head And Neck Region ◽  
Sebaceous Cyst ◽  
Teratoid Cyst

Rudolf Virchow is considered to be the first scientist to have used the word sebaceous cyst. It was thought that these lesions occurred due to retention of sebaceous secretion consequent to obstruction of sebaceous ducts of sebaceous glands, although that was found not to be the case. In all these cysts, the cavity is filled with keratin. There are six types of keratin-filled cysts, namely, epidermoid, dermoid, teratoid, keratinous, trichilemmal, and teratoma cyst, which have one common name “dermoid cyst.” Of the six, teratoid cyst is the least common. In contrast to other dermoid cysts, teratoid cysts contain tissue elements derived from all the three germ layers, namely, ectoderm, mesoderm, and endoderm. Teratomas can be differentiated from teratoid cysts by the fact that recognizable organ structures may be found in the former; examples include teeth and skin. Teratoid cysts can develop anywhere in the body but rarely arise in the head and neck region. They have never been reported in the postauricular region. In this case report, we present a case of teratoid cyst in the postauricular region in a 21-year-old female. The significance of this case lies in its rarity.

scholarly journals Aggressive Extraocular Sebaceous Carcinoma Recurring after Mohs Micrographic Surgery

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Konstantin V. Grigoryan ◽  
Laurel Leithauser ◽  
Hugh M. Gloster
Keyword(s):  
Neck Region ◽  
Surgical Excision ◽  
Sebaceous Carcinoma ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Head And Neck Region ◽  
Effective Treatment Modality ◽  
Poorly Differentiated ◽  
Adnexal Tumors ◽  
Caucasian Female

Sebaceous carcinomas (SC) are rare adnexal tumors with possible aggressive behavior usually arising in the head and neck region of adults in the seventh decade of life. Treatment has traditionally been with surgical excision with 5-6 mm wide margins but Mohs micrographic surgery (MMS) has also been reported as an effective treatment modality. We present a case of a Caucasian female renal transplant patient with a rapidly enlarging nodule on the left preauricular cheek that was excised with MMS with negative margins. The tumor recurred rapidly and metastasized ultimately leading to the death of the patient. There was some disagreement amongst pathologists as to the possible nature of the diagnosis with the original biopsy being labeled as a poorly differentiated carcinoma. We aim to highlight the potential aggressive nature of SC and review the features of the neoplasm including histological features that help in making the diagnosis.

scholarly journals A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma: Is it Still an Under-Recognized Entity?

2020 ◽  
Vol 12 (3) ◽  
pp. 255-261
Author(s):  
Khaled A. Murshed ◽  
Mohamed Ben-Gashir
Keyword(s):  
Skin Lesion ◽  
Sweat Gland ◽  
Neck Region ◽  
Lower Eyelid ◽  
Low Grade ◽  
Head And Neck Region ◽  
Mucin Production ◽  
Molecular Features ◽  
Sweat Gland Carcinoma ◽  
Gland Carcinoma

Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade sweat gland carcinoma characterized by immunoexpression of neuroendocrine markers and mucin production. It occurs most frequently at the head and neck region with strong predilection to the eyelids. Up to 2013, only few cases have been reported. However, in the following years, the number of cases reported has increased significantly, which indicates an upsurge in awareness and increased recognition of this neoplasm. Herein, we describe another case of EMPSGC in a 78-year-old man who presented with a 6-mm skin lesion at the lower eyelid. We discuss the clinical, histopathologic and immunophenotypic features of the tumor with particular emphasis on molecular features and prognosis.

scholarly journals Giant chondroid syringoma of the eyelid

2021 ◽  
Vol 6 (4) ◽  
pp. 298-301
Author(s):  
Shushruta Mohanty ◽  
Ashok Kumar Dash ◽  
Meenakshi Mohapatro ◽  
Subhashree Archana Rout
Keyword(s):  
Head And Neck ◽  
Incidence Rate ◽  
Sweat Gland ◽  
Neck Region ◽  
Lower Eyelid ◽  
Mixed Tumour ◽  
Head And Neck Region ◽  
Chondroid Syringoma

Chondroid syringoma is a rare mixed tumour of sweat gland origin that is characterised by sweat gland elements in a cartiliginous stroma. Its an uncommon cutaneous tumour of head and neck region with a reported incidence rate of 0.01% to 0.1%. Its occurence in periorbital tissues is rare and usually are small in size. Here we report a case of giant chondroid syringoma (>3 cms) arising in the lower eyelid.

A family with pheochromocytoma-paraganglioma inherited tumour syndrome

2016 ◽  
Vol 55 (01) ◽  
pp. 34-40 ◽  
Author(s):  
P. Zschieschang ◽  
V. Prasad ◽  
D. Moskopp ◽  
B. Knie ◽  
M. Plotkin
Keyword(s):  
Early Detection ◽  
Neck Region ◽  
Hereditary Disease ◽  
Head And Neck Region ◽  
Pet Ct ◽  
Highly Sensitive ◽  
Hereditary Pheochromocytoma ◽  
Genetically Determined ◽  
Mass Lesions ◽  
Pet Ct Scan

SummaryAim: Hereditary pheochromocytoma-paraganglioma syndromes are characterized by multiple pheochromocytomas (PCC) and paragangliomas (PGLs), inherited in an autosomal dominant manner. Early detection and removal of tumours may prevent or minimize complications related to mass effects and malignant transformation. Having confirmed the diagnosis, it is important to localize the tumours and reveal their extent preoperatively. This study aimed to introduce 18F-DOPA PET/CT as a highly sensitive noninvasive diagnostic tool for early detection of mass lesions in patients with pheochromocytoma-paraganglioma inherited tumour syndrome and to report about its impact on patient management. Patients, methods: We are currently supervising one of the largest documented families in Germany with genetically determined SDHD gene mutation. We performed 18F-DOPA PET/CT in order to detect tumours in asymptomatic gene carriers and enable subsequent surgical therapy. Results: In seven patients undergoing 12 18F-DOPA PET/CT scans 17 lesions have been detected. Three of these lesions, located in the head and neck region, have had no morphologic correlate in CT and one had also no morphologic correlate in MRI. Of the six histologically analyzed lesions five have been tumors (PGL or PCC) and one has been a nodular hyperplasia. This means the 18F-DOPA PET/CT scan in our study group had a sensitivity of 83%. 18F-DOPA PET/CT investigations lead to change in the management in 5/7 studied patients (70%). Conclusion: The benefits of PET/ CT in detection of pheochromocytoma and paraganglioma are well documented, but we are the first to use this technique for screening of a rare hereditary disease (estimated prevalence 0.3/100 000).

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