Interactive role of breast cancer on dyslipidemia and hypertension metabolic risk according to treatment exposure and menopausal status

Abstract Background Breast cancer (BC) is the principal cause of cancer related deaths among women worldwide. The available evidence suggests that cardio-metabolic risk factors such as dyslipidemia and hypertension may contribute differently to breast cancer severity and pathogenesis. The aim of this study is to evaluate the interactive role of BC on dyslipidemia and HTN risk according to the type of treatment exposure and menopausal status. Method Observational experimental design implemented; permit to include 134 newly-diagnosed patients who were naïve to any type of treatment interventions and 262 recently-diagnosed patients during their first three months of treatments’ exposure including chemotherapy treatments. Patients with breast cancer were evaluated for dyslipidemia and hypertension biomarkers. Results About 5.0% of breast cancer patients had dyslipidemia. The prevalence of increased triglycerides and total cholesterol were more frequent (p < 0.05) in recently-diagnosed group than in newly-diagnosed patients. While 23% of patients had overt hypertension, with higher (p < 0.05) prevalence in chemo group (28%), triglycerides was higher (p < 0.05) in postmenopausal than premenopausal BC patients (221.0 ± 5.9 vs. 195 ± 4.7 mg/dl). Similarly, the prevalence of abnormal systolic blood pressure (9% vs. 5%) and diastolic blood pressure (11% vs. 7%) was higher (p < 0.05) in postmenopausal patients. Conclusion Dyslipidemia and hypertension biomarkers were prevalent among breast cancer patients and the risk increased in postmenopausal women and after treatments’ exposure specially chemotherapy. This conclusion requires a closer attention by healthcare professionals in order to improve the outcomes after diagnosis and to enhance treatment exposure regarding postmenopausal women.

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The novel cytotoxicity of neutrophils in the peripheral blood of breast cancer patients versus women without breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.27_suppl.44 ◽

2011 ◽

Vol 29 (27_suppl) ◽

pp. 44-44

Author(s):

Z. Granot ◽

E. A. Comen ◽

L. Norton ◽

R. Benezra

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Peripheral Blood ◽

Primary Breast Tumor ◽

Newly Diagnosed ◽

Breast Cancer Patients ◽

Blood Samples ◽

Cell Kill ◽

A Cell

44 Background: Using murine mammary tumor models, recent research conducted by our laboratory at the Sloan-Kettering Institute indicates that select neutrophils are mobilized and entrained by a primary breast tumor and uniquely have the capacity to inhibit metastatic seeding in the lung (Granot Z et al. unpublished). We sought to determine whether entrainment of cytotoxic neutrophils also occurs in blood samples from women with newly diagnosed breast cancer as contrasted to those garnered from healthy women. Methods: Subjects were 21 newly diagnosed pre-operative breast cancer patients without evidence of metastatic disease, 9 healthy female volunteers with no history of any cancer, and 3 patients with newly diagnosed DCIS. Neutrophils were purified from the blood samples. Cytotoxicity was evaluated by incubating isolated neutrophils with luciferase labeled MDA-MB-231 cells. Luciferase activity, as a reflection of % cell kill, was measured using a Bio-Tek microplate luminescence reader. Results: Significant cytotoxicity was notably observed when MDA-MB-231 cells were co-cultured with neutrophils purified from patients with invasive tumors. Pre-operative breast cancer patients (n=21) had a cell kill range of 0-30% (mean = 12.1%), whereas healthy subjects (n=9) had a cell kill range of 0.2-8% (mean = 2.6%), p<0.004. DCIS patients (N=3) had a cell kill range of 3-4% (mean = 2.7). Conclusions: To date, this preliminary work is the first to demonstrate the cytotoxic role of select neutrophils in the peripheral blood of breast cancer patients as contrasted with those from women without breast cancer. Further studies are needed to evaluate the prognostic and therapeutic role of cytotoxic neutrophils.

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The association between self-consciousness about appearance and psychological adjustment among newly diagnosed breast cancer patients and survivors: The moderating role of appearance investment

Body Image ◽

10.1016/j.bodyim.2011.11.003 ◽

2012 ◽

Vol 9 (2) ◽

pp. 209-215 ◽

Cited By ~ 8

Author(s):

Helena Moreira ◽

Maria Cristina Canavarro

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Psychological Adjustment ◽

Newly Diagnosed ◽

Breast Cancer Patients ◽

Moderating Role

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Coping style as mediator between resilience, perceived social support, and health-related quality of life in Chinese mainland women newly diagnosed with breast cancer

10.21203/rs.3.rs-220162/v1 ◽

2021 ◽

Author(s):

Kaina Zhou ◽

Fan Ning ◽

Xiao Wang ◽

Wen Wang ◽

Dongfang Han

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Direct Effects ◽

Newly Diagnosed ◽

Breast Cancer Patients ◽

Mediating Role ◽

Related Quality ◽

Health Related

Abstract Background Breast cancer may impair health-related quality of life (HRQoL). We examined the mediating role of coping style (CS) in the relationship between resilience, perceived social support (PSS), and HRQoL in newly diagnosed breast cancer patients in the Chinese mainland. Methods A total of 431 patients completed a survey at two hospitals in Shaanxi Province, China, using self-report measures assessing HRQoL, resilience, PSS, and CS. A one-sample t-test analyzed differences between resilience, PSS, and CS in breast cancer patients and the corresponding norm. Multivariate linear regression analyzed the independent predictors of HRQoL. The mediating role of CS between resilience, PSS, and HRQoL were investigated using structural equation modeling (SEM). Results Participants had significantly lower scores for resilience and PSS and higher scores for the avoidance and resignation CSs than their corresponding norm. SEM analysis showed resilience had significant direct effects on CS (B:0.66, 95% CI: 0.54, 0.77) and HRQoL [0.32 (0.12, 0.49)]. PSS had significant direct effects on CS [0.18 (0.06, 0.29)]. Resilience [0.32 (0.19, 0.53)] and PSS [0.09 (0.03, 0.18)] had significant indirect effects, and resilience [0.64 (0.56, 0.71)] had significant total effects on HRQoL. CS had significant direct and total effects on HRQoL [0.48 (0.30, 0.72)]. Conclusions Newly diagnosed breast cancer patients of mainland China had lower resilience and PSS and higher negative CSs. CS appeared to mediate the influence of resilience and PSS on HRQoL. Multimodal intervention programs focusing on CS might increase the influence of resilience and PSS on HRQoL in breast cancer patients.

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