scholarly journals A Case of Self-salvation in a Determined Chloroquine Suicide Attempt

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sylvère Störmann ◽  
John Hoppe ◽  
Daniela Steinert ◽  
Matthias W. Angstwurm

Abstract This report concerns a young man who attempted suicide by ingesting a cocktail with a lethal dose of chloroquine phosphate and large amounts of diazepam. On presentation, the patient was drowsy, unresponsive and in cardiogenic shock with severely impaired left ventricular function. Active charcoal and vasopressors were administered, and despite his intoxication with diazepam, a high-dose diazepam treatment was initiated in the hospital. It is concluded that diazepam in the cocktail played a vital role in the survival of this patient. With a rise in numbers, every emergency and intensive care physician should be familiar with chloroquine poisoning.

1998 ◽  
Vol 13 (6) ◽  
pp. 269-279 ◽  
Author(s):  
Francis L. Delmonico ◽  
Jeffrey C. Reese ◽  

2014 ◽  
Vol 15 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Robert K. Fitzgerald ◽  
Jennifer C. Yu ◽  
Surender Rajasekaran ◽  
Scott E. Curtis ◽  
Daniel J. Robertson ◽  
...  

1986 ◽  
Vol 251 (2) ◽  
pp. H364-H373 ◽  
Author(s):  
R. D. Goldfarb ◽  
L. M. Nightingale ◽  
P. Kish ◽  
P. B. Weber ◽  
D. J. Loegering

Our previous studies suggested that after a median lethal dose (LD50) of endotoxin, cardiac contractility was depressed in nonsurviving dogs. The canine cardiovascular system is unlike humans in that dogs have a hepatic vein sphincter that is susceptible to adrenergic stimulation capable of raising hepatic and splanchnic venous pressures. We retested the hypothesis that lethality after endotoxin administration is associated with cardiac contractile depression in pigs, because the hepatic circulation in this species is similar to that of humans. We compared cardiac mechanical function of pigs administered a high dose (250 micrograms/kg) or a low dose (100 micrograms/kg) endotoxin by use of the slope of the end-systolic pressure-diameter relationship (ESPDR) as well as other measurements of cardiac performance. In all the pigs administered a high dose, ESPDR demonstrated a marked, time-dependent depression, whereas we observed no significant ESPDR changes after low endotoxin doses. The other cardiodynamic variables were uninterpretable, due to the significant changes in heart rate, end-diastolic diameter (preload), and aortic diastolic pressure (afterload). Plasma myocardial depressant factor activity accumulated in all endotoxin-administered animals, tending to be greater in the high-dose group. In this group, both subendocardial blood flow and global function were depressed, whereas pigs administered the low dose of endotoxin demonstrated slight, but nonsignificant, increases in flow and function. These observations indicate that myocardial contractile depression is associated with a lethal outcome to high doses of endotoxin. One possible mechanism for this loss of contractile function may be a relative hypoperfusion of the subendocardium.


2019 ◽  
Vol 29 (3) ◽  
pp. 435-438
Author(s):  
Mark R. Garrelfs ◽  
Esther Hoppenreijs ◽  
Ronald B. Tanke

AbstractThe NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome is a rare novel autoinflammatory disorder. Cardiac involvement has not been previously reported. We present a 12-year-old girl with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome who was diagnosed with severely impaired left ventricular function and complete left bundle branch block during an exacerbation of the disease. Cardiac dysfunction proved to be rapidly reversible after initiation of high-dose methylprednisolone.


2021 ◽  
Vol 3 (2) ◽  
pp. 10-17
Author(s):  
 Dr. Padmakumar V Arayamparambil ◽  
Mrs. Deepa C Velayudhan

2007 ◽  
Vol 8 (5) ◽  
pp. 459-463 ◽  
Author(s):  
Vishal Jatana ◽  
Jonathan Gillis ◽  
Boyd H. Webster ◽  
Lesley C. Adès

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