scholarly journals CD4/CD8 ratio as a predictor for the occurrence of metabolic syndrome in HIV / AIDS patients during 6 months of cART therapy

2019 ◽  
Vol 38 (4) ◽  
pp. 489-495 ◽  
Author(s):  
Refet Gojak ◽  
Vesna Hadžiosmanović ◽  
Rusmir Baljić ◽  
Lamija Zečević ◽  
Jozo Ćorić ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Biochemical Parameters ◽  
Case Control Study ◽  
Case Control ◽  
Hiv Positive ◽  
Retrospective Case ◽  
Aids Patients ◽  
Immunological Parameters ◽  
Control Study ◽  
Hiv Aids

Summary Background HIV infection is characterized by progressive depletion of CD4+ T cells due to their reduced synthesis and increased destruction followed by marked activation and expansion of CD8+ T lymphocytes. CD4/CD8 ratio was traditionally described as a marker of immune system ageing in the general population, but it increasingly appears as a marker of different outcomes in the HIV-infected population. The main objective of this study is to examine the power of CD4/CD8 ratio in predicting the occurrence of metabolic syndrome (MetS) in HIV-positive patients receiving cART therapy. Methods 80 HIV/AIDS subjects were included in a retrospective case-control study. Flow cytometry was used to determine the percentage of CD4+ and CD8+ cells in peripheral blood of these patients. The values of biochemical parameters (triglycerides, HDL, blood sugar, blood counts), immunological parameters (CD4/CD8, PCR), anthropometric measurements and type of cART therapy were evaluated in this study. Results After six months of cART therapy 19 (23.8%) subjects had all the elements necessary for making the diagnosis of MetS. Using multivariate analysis CD4/CD8 ratio was statistically significant (p < 0.05) and had the largest effect on development of MetS (Wald = 9.01; OR = 0.45), followed by cART (Wald = 7.87; OR = 0.10) and triglycerides (Wald = 5.27; OR = 1.7). On the other hand, body weight and waist circumference showed no statistically significant effect on the development of MetS after six months of cART, p > 0.05. Conclusions CD4/CD8 ratio proved to be a significant marker for prediction of metabolic syndrome in HIV/AIDS patients.

scholarly journals Cardiovascular and metabolic syndrome risk among men with and without erectile dysfunction: case-control study

2010 ◽  
Vol 128 (3) ◽  
pp. 137-140 ◽  
Author(s):  
João Paulo Zambon ◽  
Rafaela Rosalba de Mendonça ◽  
Marcelo Langer Wroclawski ◽  
Amir Karam Junior ◽  
Raul D. Santos ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Erectile Dysfunction ◽  
Cardiovascular Risk ◽  
Erectile Function ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Healthcare Program ◽  
Severity Of Erectile Dysfunction ◽  
Control Study

CONTEXT AND OBJECTIVE: Erectile dysfunction has been associated with cardiovascular diseases. The aim here was to evaluate cardiovascular risk through the Framingham Risk Score (FRS) criteria, C-reactive protein (CRP) assays and presence of metabolic syndrome (MS) in men with and without erectile dysfunction diagnosed within a healthcare program. DESIGN AND SETTING: A retrospective case-control study was conducted. The patients were selected from a healthcare program at the Hospital Israelita Albert Einstein, between January and December 2007. METHODS: 222 men were retrospectively selected, and they were divided into two groups: men with erectile dysfunction (n = 111) and men without erectile dysfunction (n = 111). The patients were stratified according to the International Index of Erectile Function-Erectile Function domain (IIEF-EF domain). CRP and FRS were analyzed and the two groups were compared. RESULTS: The CRP levels were significantly higher among men with erectile dysfunction (P = 0.04). Patients with erectile dysfunction also had high FRS (P = 0.0015). CRP and FRS did not correlate with the severity of erectile dysfunction. The presence of metabolic syndrome was greater among men with erectile dysfunction (P < 0.05). The severity of erectile dysfunction was directly associated with metabolic syndrome. CONCLUSION: Men with erectile dysfunction presented higher cardiovascular risk according to the FRS criteria and CRP measurements. Severe erectile dysfunction seemed to have a correlation with metabolic syndrome.

W1452: Colonoscopic Findings in Symptomatic HIV Positive African American Patients: A Retrospective Case Control Study From an Inner City Hospital

2010 ◽  
Vol 71 (5) ◽  
pp. AB332
Author(s):  
Ramakrishna Chakilam ◽  
Samyukta Chava ◽  
Rajesh Chintala ◽  
Satya Chalasani ◽  
Andrew Sanderson ◽  
...  
Keyword(s):  
African American ◽  
Inner City ◽  
Case Control Study ◽  
Case Control ◽  
Hiv Positive ◽  
City Hospital ◽  
Retrospective Case ◽  
Control Study

Predictive Markers of First Line Failure of Anti-Retroviral Therapy in HIV Positive Patients in Pakistan

2021 ◽  
Vol 15 (12) ◽  
pp. 3238-3240
Author(s):  
M. Waqar Aslam ◽  
A. Ashar Ghuman ◽  
Saveela Sadaqat ◽  
Saif Ullah ◽  
M. Akram ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Hiv Treatment ◽  
Predictive Markers ◽  
Cd4 Count ◽  
Hiv Positive ◽  
First Line ◽  
Retrospective Case ◽  
Treatment Centre ◽  
Control Study

Background: HIV treatment centres register HIV positive patients, specially trained doctors prescribe Antiretroviral Therapy to the selected cases that fulfill the criteria for initiation of HAART. Aim: To establish predictive markers of failure of 1st line ART in HIV positive patients on first line ART under treatment in HIV Treatment Centre of PIMS Islamabad. Study design: Retrospective case control study. Methodology: Retrospective case control study done at HIV Treatment Centre at PIMS Islamabad. Cases were patients who failed 1st line ART and started on second line ART from November 2005 to June 2020. Patients responding well to first line ART since more than five years or more were taken as controls. Various factors were analyzed in both groups and compared to find their level of significance. Data was analyzed by SPSS software, version 25 as qualitative variables were expressed as frequencies and percentages. Results: CD4 count of all 38 patients was below 300 on diagnosis. In 21 patients (55.3%) CD4 count initially increased but there was no rise in CD4 count in 17 patients (44.7%) after start of 1st line ART. Conclusion: We concluded that CD4 count is one of the most important predictive markers in success or failure of ART. Rising number of CD4 count on follow up visits gives a strong indication that patient is responding well to the prescribed treatment and is likely to benefit from the current regimen of ARVs for a longer period in future. Keywords: Predictive Markers, CD4 count, Viral Load, HIV, ART, Compliance and Co-morbidities

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