Motor speed and reaction time in HIV/AIDS patients: a case-control study

2006 ◽  
Vol 5 (3) ◽  
pp. 217-220 ◽  
Author(s):  
Olubunmi Ogunrin ◽  
Francis Odiase
Keyword(s):  
Reaction Time ◽  
Case Control Study ◽  
Case Control ◽  
Motor Speed ◽  
Aids Patients ◽  
Control Study ◽  
Hiv Aids

scholarly journals CD4/CD8 ratio as a predictor for the occurrence of metabolic syndrome in HIV / AIDS patients during 6 months of cART therapy

2019 ◽  
Vol 38 (4) ◽  
pp. 489-495 ◽  
Author(s):  
Refet Gojak ◽  
Vesna Hadžiosmanović ◽  
Rusmir Baljić ◽  
Lamija Zečević ◽  
Jozo Ćorić ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Biochemical Parameters ◽  
Case Control Study ◽  
Case Control ◽  
Hiv Positive ◽  
Retrospective Case ◽  
Aids Patients ◽  
Immunological Parameters ◽  
Control Study ◽  
Hiv Aids

Summary Background HIV infection is characterized by progressive depletion of CD4+ T cells due to their reduced synthesis and increased destruction followed by marked activation and expansion of CD8+ T lymphocytes. CD4/CD8 ratio was traditionally described as a marker of immune system ageing in the general population, but it increasingly appears as a marker of different outcomes in the HIV-infected population. The main objective of this study is to examine the power of CD4/CD8 ratio in predicting the occurrence of metabolic syndrome (MetS) in HIV-positive patients receiving cART therapy. Methods 80 HIV/AIDS subjects were included in a retrospective case-control study. Flow cytometry was used to determine the percentage of CD4+ and CD8+ cells in peripheral blood of these patients. The values of biochemical parameters (triglycerides, HDL, blood sugar, blood counts), immunological parameters (CD4/CD8, PCR), anthropometric measurements and type of cART therapy were evaluated in this study. Results After six months of cART therapy 19 (23.8%) subjects had all the elements necessary for making the diagnosis of MetS. Using multivariate analysis CD4/CD8 ratio was statistically significant (p < 0.05) and had the largest effect on development of MetS (Wald = 9.01; OR = 0.45), followed by cART (Wald = 7.87; OR = 0.10) and triglycerides (Wald = 5.27; OR = 1.7). On the other hand, body weight and waist circumference showed no statistically significant effect on the development of MetS after six months of cART, p > 0.05. Conclusions CD4/CD8 ratio proved to be a significant marker for prediction of metabolic syndrome in HIV/AIDS patients.

scholarly journals Correlating cognition and cortical excitability with pain in fibromyalgia: a case control study

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Vikas Kumar Tiwari ◽  
Srishti Nanda ◽  
Suvercha Arya ◽  
Uma Kumar ◽  
Ratna Sharma ◽  
...  
Keyword(s):  
Reaction Time ◽  
Sleep Quality ◽  
Daytime Sleepiness ◽  
Case Control Study ◽  
Color Word ◽  
Case Control ◽  
Corticomotor Excitability ◽  
Word Task ◽  
Control Study

Abstract Background Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal symptoms, primarily attributed to sensitization of somatosensory system carrying pain. Few reports have investigated the impact of fibromyalgia symptoms on cognition, corticomotor excitability, sleepiness, and the sleep quality — all of which can deteriorate the quality of life in fibromyalgia. However, the existing reports are underpowered and have conflicting directions of findings, limiting their generalizability. Therefore, the present study was designed to compare measures of cognition, corticomotor excitability, sleepiness, and sleep quality using standardized instruments in the recruited patients of fibromyalgia with pain-free controls. Methods Diagnosed cases of fibromyalgia were recruited from the Rheumatology department for the cross-sectional, case-control study. Cognition (Mini-Mental State Examination, Stroop color-word task), corticomotor excitability (Resting motor threshold, Motor evoked potential amplitude), daytime sleepiness (Epworth sleepiness scale), and sleep quality (Pittsburgh sleep quality index) were studied according to the standard procedure. Results Thirty-four patients of fibromyalgia and 30 pain-free controls were recruited for the study. Patients of fibromyalgia showed decreased cognitive scores (p = 0.05), lowered accuracy in Stroop color-word task (for color: 0.02, for word: 0.01), and prolonged reaction time (< 0.01, < 0.01). Excessive daytime sleepiness in patients were found (< 0.01) and worsened sleep quality (< 0.01) were found. Parameters of corticomotor excitability were comparable between patients of fibromyalgia and pain-free controls. Conclusions Patients of fibromyalgia made more errors, had significantly increased reaction time for cognitive tasks, marked daytime sleepiness, and impaired quality of sleep. Future treatment strategies may include cognitive deficits and sleep disturbances as an integral part of fibromyalgia management.

Reaction Time and Brake Pedal Depression Following Arthroscopic Hip Surgery: A Prospective Case-Control Study

2018 ◽  
Vol 34 (5) ◽  
pp. 1463-1470.e1 ◽  
Author(s):  
George C. Balazs ◽  
Michael A. Donohue ◽  
Alaina M. Brelin ◽  
Daniel I. Brooks ◽  
Michael P. McCabe ◽  
...  
Keyword(s):  
Reaction Time ◽  
Case Control Study ◽  
Case Control ◽  
Hip Surgery ◽  
Brake Pedal ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Determinants of Tuberculosis Among HIV Infected Adults in Horro Guduru Wollega Zone, West Ethiopia: A Facility-Based Case-Control Study

2020 ◽  
Author(s):  
Zelalem Belay Adugna ◽  
Belachew Etana Tolessa ◽  
Mekdes Tigistu Yilma
Keyword(s):  
Protective Effect ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
People Living With Hiv ◽  
Factors Associated ◽  
The Past ◽  
Living With Hiv ◽  
Control Study ◽  
Hiv Aids

Abstract Background: Tuberculosis is a contagious air born disease caused by Mycobacterium tuberculosis species and the leading causes of morbidity and mortality among people living with HIV/AIDS worldwide. Globally, it causes ill-health among millions of people living with HIV/AIDS each year. Objective: To identify determinants of Tuberculosis among HIV infected adults in public health facilities, in Horro Guduru Wollega Zone, 2019. Methods: Unmatched case-control study was conducted among 127 cases and 255 controls which were selected using systematic random sampling technique. Data were collected by record review and through face to face interview. Then, analysis was done using SPSS version 25.To identify determinants of tuberculosis multivariable logistic regression was employed. Adjusted odds ratio was calculated with 95 % CI to show strength of association and P-value < 0.05 was used to declare statistical significance.Results: - A total of 127 cases and 255 controls were participated into the study with 97.2% response rate. Aged ≥35 years [ AOR= 2.63, 95% CI(1.29,5.36)], alcohol consumption [AOR=3.34,95%CI(1.68,6.99)], Having CD4 cells <200 [AOR=3.67, 95% CI (1.5, 9.1)], Having Haemoglobin <11g/dl [AOR=3.77, 95%CI(1.84,7.72)], Imprisoned in the past 2 years [AOR=4.22, 95%CI(1.56, 11.37)], Living with TB patients in the same house [AOR=14.97, 95% CI(1.99, 21.63)] were factors associated with TB among HIV infected adults. Importantly, using Cotrimoxazole prophylaxis [AOR=0.193, 95% CI(0.81,0.46)] had a protective effect from acquiring TB. Conclusion and Recommendation: Being in old age, alcohol use, Chewing khat, Having CD4cells <200, Advanced WHO clinical stage, Hgb <11g/dl, Imprisoned in the past 2 years, History of previous TB and living with TB patients in the same house were factors associated with TB/HIV co-infection. Using Cotrimoxazole had a protective effect from acquiring TB/HIV co-infection. For most of these determinants interventions can be made at individual and institutional levels, whereas, some factors need societal level integrations.

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