scholarly journals Sleep apnea syndrome and heart failure—mechanisms and consequences

Pneumologia ◽  
2019 ◽  
Vol 68 (2) ◽  
pp. 61-67
Author(s):  
Carmen Loredana Ardelean ◽  
Daniel Florin Lighezan ◽  
Sorin Pescariu ◽  
Valentin Nadasan ◽  
Roxana Pleava ◽  
...  

Abstract Heart failure (HF) remains a major public health issue despite advances in treatment, being associated with increased morbidity and mortality, multiple hospitalization and, implicitly, very high economic costs. Therefore, it becomes increasingly important to identify and treat factors or comorbidities that contribute to the progression of HF. Breathing disorders during sleep (sleep-disordered breathing), especially sleep apnea syndrome, obstructive or central form, may be one of these factors.

2011 ◽  
Vol 12 ◽  
pp. S105
Author(s):  
Vincent Pichot ◽  
Frederic Roche ◽  
Florian Chouchou ◽  
Emilia Sforza ◽  
Renaud Tamisier ◽  
...  

2015 ◽  
Vol 12 (2) ◽  
pp. 24-30
Author(s):  
Natalya Viktorovna Strueva ◽  
Galina Afanas'evna Melnichenko ◽  
Mikhail Gur'evich Poluektov ◽  
Larisa Viktorovna Savel'eva ◽  
Gulinara Viktorovna Katsya ◽  
...  

The aim of research was to estimate the influence of hormone metabolism and sleep apnea on patients with obesity. 76 patients (37 males and 39 females) with obesity were included in this study. After night polysomnography all patients were divided in two groups comparableby age, sex ratio and BMI. The first group consisted of 41 patients with obstructive sleep apnea syndrome (OSAS), the second (controls) – 35 patients without breath disorders during sleep. OSAS is accompanied by the increase in urinary cortisol during the night, high levels ofbasal insulin, disturbances of hepatic production of IGF-1, dysfunction of the pituitary-gonadal axis. Our results show that sleep-related breathing disorders render markedly and negatively affect on hormonal parameters of patients with obesity. As a reliable difference of basalsecretion of orexin A in obese patients with and without OSAS was not revealed (42,0 [14; 99,5] vs. 18,0 [14,5; 124,5] pg/ml; р=0,9), we were not able to show the existence that the existence of OSAS is followed by any special changes of activity of the orexin system.


Author(s):  
E. A. Medvedeva ◽  
L. S. Korostovtseva ◽  
Yu. V. Sazonova ◽  
M. V. Bochkarev ◽  
Yu. V. Sviryaev ◽  
...  

2020 ◽  
Vol 49 ◽  
Author(s):  
A. D. Palman ◽  
A. S. Akselrod

Patients with obstructive sleep apnea syndrome (OSAS) are characterized by various cardiac arrhythmias during sleep. However, while the association between OSAS and atrial fibrillation is considered proven, the presence of a pathophysiological link between sleep apnea and ventricular arrhythmias remains a matter of debate.We present a case of a 51-year old man with arterial hypertension and type 2 diabetes who was referred for sleep assessment after being diagnosed with predominantly nocturnal cardiac arrhythmias. Overnight cardiorespiratory monitoring showed that the patient had a severe OSAS with an apnea-hypopnea index of 57 per hour and a minimal SpO2 during sleep of 73%. On the channel of electrocardiogram (ECG) frequent single monomorphic ventricular extrasystoles, eventually of the bigeminal type, and one short paroxysm of a wide-complex regular rhythm of 60 beats per minute (accelerated idioventricular rhythm) associated with prolonged apnea were identified. Continuous airway positive pressure (CPAP) therapy was started which was able to control for breathing disorders during sleep. At the follow-up 24-hours Holter ECG monitoring, the numbers of ventricular extrasystoles during sleep decreased 2-fold, without any idioventricular rhythm episodes.The clinical case clearly illustrates that in some patients with OSAS, first of all, in those with severe OSAS and comorbid cardiovascular disorders, breathing disorders during sleep can trigger ventricular arrhythmias. In such patients, CPAP therapy could both improves their quality of life and provide an indirect antiarrhythmic effect.


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