Modeling of supercritical fluid extraction of flavonoids from Calycopteris floribunda leaves

2014 ◽  
Vol 68 (3) ◽  
Author(s):  
Xiong Liu ◽  
Dong-Liang Yang ◽  
Jia-Jia Liu ◽  
Kuan Xu ◽  
Guo-Hui Wu
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Extraction Process ◽  
Optimal Conditions ◽  
Fluid Extraction ◽  
Pressure Method ◽  
Organic Solvent Extraction ◽  
Drug Lead ◽  
Temperature And Pressure ◽  
Central Composite

AbstractThe aim of this study was to obtain flavonoids extracts from Calycopteris floribunda leaves using supercritical fluid extraction (SFE) with CO2 and a co-solvent. Pachypodol, a potential anticancer drug lead compound separated from the extracts, was examined. Classical organic solvent extraction (CE) with ethanol was performed to evaluate the high pressure method. HPLC analysis was introduced to interpret the differences between SFE and CE extracts in terms of antioxidant activity and the concentration of pachypodol. SFE kinetics and mathematical modeling of the overall extraction curves (OEC) were investigated. Evaluation of the models against experimental data showed that the Sovová model performs the best. The supercritical fluid extraction process was optimized using a central composite design (CCD), where temperature and pressure were adjusted. The optimal conditions of SFE were: pressure of 30 MPa and temperature of 35°C.

Influence of the CO2 Quality in the Antioxidant Activity of Rosemary Extracts Dearomatized by Supercritical Fluid Extraction

2001 ◽  
Vol 7 (2) ◽  
pp. 177-182 ◽  
Author(s):  
E. Ibanez ◽  
S. Lopez-Sebastian ◽  
J. Fernandez ◽  
J. Tabera ◽  
J. M. Bueno ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Experimental Design ◽  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Sunflower Oil ◽  
Extraction Process ◽  
Taguchi Experimental Design ◽  
Optimal Conditions ◽  
Fluid Extraction

The effect of the CO2 quality (mainly related to CO2 content) in the antioxidant activity of rosemary extracts deodorized by using a supercritical fluid extraction process is analyzed. A Taguchi experimental design was used to study the influence of the CO2 quality on the antioxidant activity of the rosemary dearomatized extracts. The antioxidant activity of the rosemary extracts obtained in optimal conditions was tested with sunflower oil.

scholarly journals Supercritical fluid extraction: Application in the food industry

2002 ◽  
Vol 56 (5) ◽  
pp. 179-190 ◽  
Author(s):  
Dejan Skala ◽  
Irena Zizovic ◽  
Sladjana Gavrancic
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Supercritical Fluids ◽  
Food Industry ◽  
Critical Pressure ◽  
Extraction Process ◽  
Fluid Extraction ◽  
Polar Solvents ◽  
Molecular Weights ◽  
Temperature And Pressure

Supercritical fluid extraction is an extraction process realized with supercritical fluids, which are at a temperature and pressure above their critical temperature and critical pressure. This process has shown to be very efficient one for the isolation of different substances of medium molecular weights and molecules of relatively low polarity. The solubility of more polar substances in supercritical fluids can be improved by the addition of small amounts of other polar solvents (cosolvent) to the supercritical fluids, which is the main solvent in extraction process. The advantage of supercritical extraction compared to other extraction procedures (the application of classical organic solvents hydrodistillation, distillation with steam) is that SFE is usually performed at moderate temperature (e.g. with SF CO2 at 40-70?C) so it can be applied for the separation of different substances which are thermally unstable and have a larger vapour pressure. All of these facts indicate that SFE is of special interest for the food and pharmaceutical industry.

scholarly journals Overview of soft intelligent computing technique for supercritical fluid extraction

2020 ◽  
Vol 9 (2) ◽  
pp. 117
Author(s):  
Sitinoor Adeib Idris ◽  
Masturah Markom
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Intelligent Systems ◽  
Extraction Process ◽  
Industrial Applications ◽  
Physical Models ◽  
Experimental Result ◽  
Fluid Extraction ◽  
Computing Technique ◽  
Smart System

<span>Optimization of Supercritical Fluid Extraction process with mathematical modeling is essential for industrial applications. The response surface methodology (RSM) has been proven to be a useful and effective statistical method for studying the relationships between measured responses and independent factors. Recently there are growing interest in applying smart system or artificial technique to model and simulate a chemical process and also to predict, compute, classify and optimize as well as for process control. This system works by generalizing the experimental result and the process behavior and finally predict and estimate the problem. This smart system is a major assistance in the development of process from laboratory to pilot or industrial. The main advantage of intelligent systems is that the predictions can be performed easily, fast, and accurate way, which physical models unable to do. This paper shares several works that have been utilizing intelligent systems for modeling and simulating the supercritical fluid extraction process.</span>

scholarly journals Optimizing the supercritical fluid extraction process of bioactive compounds from processed tomato skin by-products

2020 ◽  
Vol 40 (3) ◽  
pp. 692-697
Author(s):  
Teresa Maria PELLICANÒ ◽  
Vincenzo SICARI ◽  
Monica Rosa LOIZZO ◽  
Mariarosaria LEPORINI ◽  
Tiziana FALCO ◽  
...  
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Bioactive Compounds ◽  
Extraction Process ◽  
Fluid Extraction ◽  
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