scholarly journals A study of in situ fluid bed melt granulation using response surface methodology / Uporaba metodologije odgovornih površin za študij in situ granulacije s talinami v zvrtinčenih plasteh

2012 ◽  
Vol 62 (4) ◽  
pp. 497-513 ◽  
Author(s):  
Simon Kukec ◽  
Franc Vrečer ◽  
Rok Dreu
Keyword(s):  
Particle Size ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Air Temperature ◽  
Binder Content ◽  
Drug Dissolution ◽  
Optimal Process ◽  
Fluid Bed ◽  
Melt Granulation

The objective of this work was to investigate the influence of selected individual variables (binder content, inlet air temperature, and product endpoint temperature) of in situ fluid bed melt granulation on the granule particle size distribution and percentage of dissolved carvedilol using a three-factor, five-level circumscribed central composite design. Increased binder content had the effect of increasing the granule particle size and drug dissolution rate. The effect of inlet air temperature and product endpoint temperature was found to be more pronounced in case of granule particle size parameters. Within the studied intervals, the optimal quantity of binder as well as optimal process parameters were identified and validated using response surface methodology. Utilizing these optimal process and formulation parameters, successful scaling up of the fluid bed melt granulation process was carried out. Granule characteristics obtained at pilot scale are comparable to those obtained at laboratory scale.

Optimization on Influencing Factors of Fracture Toughness of Corundum-Mullite Toughened by In Situ Synthesized Mullite Whiskers by Response Surface Methodology

2012 ◽  
Vol 581-582 ◽  
pp. 819-822 ◽  
Author(s):  
Bin Meng ◽  
Jin Hui Peng
Keyword(s):  
Fracture Toughness ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Response Surface Method ◽  
Sintering Temperature ◽  
Surface Method ◽  
Mullite Whiskers ◽  
Optimized Conditions ◽  
Addition Amount

The corundum-mullite was toughened by in-situ synthesized mullite whiskers and the process parameters influencing the fracture toughness of corundum-mullite, such as sintering temperature, addition amount of AlF3 and V2O5, were optimized by means of response surface method. Corundum-mullite with fracture toughness of 9.44 MPa.m-1/2 could be obtained under the optimized conditions, i.e. sintering temperature of 1400°C, 4.8 wt.% of AlF3 and 5.8 wt.% of V2O5. The results showed that it was feasible to prepare corundum-mullite toughened by in-situ synthesized mullite whiskers by the optimized parameters. In addition, an accurate model based on response surface method was proposed to predict the experimental results.

scholarly journals OPTIMIZATION OF REFLUX EXTRACTION FOR CAESALPINIA SAPPAN LINN. WOOD BY USING RESPONSE SURFACE METHODOLOGY

2020 ◽  
Vol 83 (1) ◽  
pp. 85-92
Author(s):  
Mohd Azahar Mohd Ariff ◽  
Muhammad Syafiq Abd Jalil ◽  
Noor ‘Aina Abdul Razak ◽  
Jefri Jaapar
Keyword(s):  
Particle Size ◽  
Response Surface Methodology ◽  
Drinking Water ◽  
Response Surface ◽  
Extraction Time ◽  
Percentage Error ◽  
Optimum Conditions ◽  
Caesalpinia Sappan ◽  
The Mean ◽  
Repeated Runs

Caesalpinia sappan linn. (CSL) is a plant which is also known as Sepang tree contains various medicinal values such as to treat diarrhea, skin rashes, syphilis, jaundice, drinking water for blood purifying, diabetes, and to improve skin complexion. The aim of this study is to obtain the most optimum condition in terms of the ratio of sample to solvent, particle size, and extraction time to get the highest amount of concentration of the CSL extract. In this study, the ranges of each parameters used were: ratio sample to solvent: 1.0:20, 1.5:20, 2.0:20, 2.5:20, 3.0:20, particle size: 1 mm, 500 um, 250 um, 125 um, 63 um, and extraction time: 1 hr, 2 hr, 3 hr, 4 hr, 5 hr. The concentration was analyzed using a UV-vis spectrophotometer. The optimum conditions were obtained by response surface methodology. From the design, 20 samples were run throughout this experiment. The optimized value from the RSM were 2.0:20 for ratio sample to solvent, 125 µm of particle size and 2.48 hours with the concentration of 37.1184 ppm. The accuracy of the predictive model was validated with 2 repeated runs and the mean percentage error was less than 3%. This confirmed the model’s capability for optimizing the conditions for the reflux extraction of CSL’s wood.

Optimization of biodiesel production by in situ transesterification from dry biomass of Choricystis minor var. minor via response surface methodology

Biofuels ◽  
2019 ◽  
pp. 1-7
Author(s):  
Aline Terra Soares ◽  
Emmanuel Bezerra D’Alessandro ◽  
Rafael Garcia Lopes ◽  
Roberto Bianchini Derner ◽  
Nelson Roberto Antoniosi Filho
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Biodiesel Production ◽  
In Situ Transesterification ◽  
Dry Biomass ◽  
Choricystis Minor
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