scholarly journals Early-stage visual processing abnormalities in high-functioning autism spectrum disorder (ASD)

2010 ◽  
Vol 1 (2) ◽  
Author(s):  
Joshua Baruth ◽  
Manuel Casanova ◽  
Lonnie Sears ◽  
Estate Sokhadze
Keyword(s):  
Autism Spectrum Disorder ◽  
Visual Processing ◽  
Auditory Processing ◽  
Physiological Stress ◽  
Early Stage ◽  
Event Related Potentials ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Control Group ◽  
Related Potentials

AbstractIt has been reported that individuals with autism spectrum disorder (ASD) have abnormal responses to the sensory environment. For these individuals sensory overload can impair functioning, raise physiological stress, and adversely affect social interaction. Early-stage (i.e. within 200 ms of stimulus onset) auditory processing abnormalities have been widely examined in ASD using event-related potentials (ERP), while ERP studies investigating early-stage visual processing in ASD are less frequent. We wanted to test the hypothesis of early-stage visual processing abnormalities in ASD by investigating ERPs elicited in a visual oddball task using illusory figures. Our results indicate that individuals with ASD have abnormally large cortical responses to task irrelevant stimuli over both parieto-occipital and frontal regions-of-interest (ROI) during early stages of visual processing compared to the control group. Furthermore, ASD patients showed signs of an overall disruption in stimulus discrimination, and had a significantly higher rate of motor response errors.

scholarly journals A-060 A Developmental Analysis of Auditory Processing and Symptom Severity in Children with Autism Spectrum Disorder

2020 ◽  
Vol 35 (6) ◽  
pp. 850-850
Author(s):  
Cotter M ◽  
Tikir S ◽  
Molholm S
Keyword(s):  
Autism Spectrum Disorder ◽  
Symptom Severity ◽  
Auditory Processing ◽  
Event Related Potentials ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cross Sectional ◽  
Severity Scores ◽  
Related Potentials

Abstract Objective Children with Autism Spectrum Disorder (ASD) exhibit abnormal responses to sensory events that interfere with the development of social communication. Previous studies have demonstrated that abnormal auditory processing contributes to this response; however, it remains unclear how this deficit is related to ASD severity throughout development. This cross-sectional study examines the relationship between auditory processing and symptom severity in a developmental sample of children, hypothesizing that auditory sensory event related potentials (ERP) will be associated with ASD severity as measured by the Autism Diagnostic Observation Schedule (ADOS), and that there will be interaction between age and severity. Method This study included children (ages 6-18) with ASD (n = 116, female = 21) as diagnosed by the ADOS and typically developing children (n = 142, female =76). Exclusion criteria includes Performance IQ below 85, abnormal hearing or vision, and presence of a neurological disorder. Participants performed an audiovisual reaction task in which they pressed a button on a response pad when seeing or hearing the instructed stimuli while recording electroencephalography (EEG). Results Electrophysiological indices of auditory processing were identified based on peak amplitudes of averaged N1 responses, an early auditory ERP. A positive correlation was found between severity scores and N1 peak amplitudes (N1a (r(85) = .56, p < .001) and N1b (r(85) = .44, p < .001)). Approximately 72% (R2 = .716) of symptom severity variance can be accounted for by linear combination of ERPs. A linear model demonstrated a significant age by severity interaction with N1b, B = -2.7, F(2,84) = 20.6, p < .001. Conclusions Abnormal early auditory processing is associated with symptom severity, and this effect is more pronounced throughout earlier ages.

scholarly journals Potenciais evocados auditivos corticais no transtorno do espectro do autismo: revisão sistemática

CoDAS ◽  
2021 ◽  
Vol 33 (2) ◽  
Author(s):  
Mariana Keiko Kamita ◽  
Liliane Aparecida Fagundes Silva ◽  
Carla Gentile Matas
Keyword(s):  
Autism Spectrum Disorder ◽  
Evoked Potentials ◽  
Autistic Disorder ◽  
Web Of Science ◽  
Event Related Potentials ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cochrane Library ◽  
Related Potentials

RESUMO Objetivo Identificar e analisar quais são os achados característicos dos Potenciais Evocados Auditivos Corticais (PEAC) em crianças e/ou adolescentes com Transtorno do Espectro do Autismo (TEA) em comparação do desenvolvimento típico, por meio de uma revisão sistemática da literatura. Estratégia de pesquisa Após formulação da pergunta de pesquisa, foi realizada uma revisão da literatura em sete bases de dados (Web of Science, Pubmed, Cochrane Library, Lilacs, Scielo, Science Direct, e Google acadêmico), com os seguintes descritores: transtorno do espectro autista (autism spectrum disorder), transtorno autístico (autistic disorder), potenciais evocados auditivos (evoked potentials, auditory), potencial evocado P300 (event related potentials, P300) e criança (child). A presente revisão foi cadastrada no Próspero, sob número 118751. Critérios de seleção Foram selecionados estudos publicados na integra, sem limitação de idioma, entre 2007 e 2019. Análise dos dados: Foram analisadas as características de latência e amplitude dos componentes P1, N1, P2, N2 e P3 presentes nos PEAC. Resultados Foram localizados 193 estudos; contudo 15 estudos contemplaram os critérios de inclusão. Embora não tenha sido possível identificar um padrão de resposta para os componentes P1, N1, P2, N2 e P3, os resultados da maioria dos estudos demonstraram que indivíduos com TEA podem apresentar diminuição de amplitude e aumento de latência do componente P3. Conclusão Indivíduos com TEA podem apresentar respostas diversas para os componentes dos PEAC, sendo que a diminuição de amplitude e aumento de latência do componente P3 foram as características mais comuns.

COGNITIVE DYSFUNCTIONS IN A MINIMALLY VERBAL (MV) PATIENT WITH AUTISM SPECTRUM DISORDER (ASD)

2019 ◽  
Vol 17 (3) ◽  
pp. 301-310
Author(s):  
Katarzyna Markiewicz ◽  
Bożydar L.J. Kaczmarek ◽  
Juri D. Kropotov ◽  
Weronika D. MacQueen ◽  
Bruce D. MacQueen ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Cognitive Skills ◽  
Event Related Potentials ◽  
Spoken Language ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Minimally Verbal ◽  
Cognitive Dysfunctions ◽  
Related Potentials ◽  
Brain Changes

The aim of this study was to examine the neurophysiological correlates of cognitive dysfunctions in a patient with the minimally verbal variant of Autism Spectrum Disorder (ASD + MV), who after reaching adulthood showed progressive deterioration of his cognitive skills. The patient was a 25-year-old male, diagnosed with ASD. He never developed spoken language, and communicated only by gesturing or writing on a computer. Our findings confirmed comorbidity of ASD and epilepsy, accompanied by dysfunction of cognitive control. We also found that spontaneous EEG and event-related potentials (ERPs) in a cued GO/NOGO task can be used to assess functional brain changes concomitant with ASD.

scholarly journals Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development

Autism ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 1093-1110
Author(s):  
Franc CL Donkers ◽  
Mike Carlson ◽  
Sarah E Schipul ◽  
Aysenil Belger ◽  
Grace T Baranek
Keyword(s):  
Autism Spectrum Disorder ◽  
Developmental Delay ◽  
Event Related Potentials ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Sensory Response ◽  
Typical Development ◽  
Response Patterns ◽  
Related Potentials

Atypical sensory response patterns are common in children with autism and developmental delay. Expanding on previous work, this observational electroencephalogram study assessed auditory event-related potentials and their associations with clinically evaluated sensory response patterns in children with autism spectrum disorder ( n = 28), developmental delay ( n = 17), and typical development ( n = 39). Attention-orienting P3a responses were attenuated in autism spectrum disorder relative to both developmental delay and typical development, but early sensory N2 responses were attenuated in both autism spectrum disorder and developmental delay relative to typical development. Attenuated event-related potentials involving N2 or P3a components, or a P1 × N2 interaction, were related to more severe hyporesponsive or sensory-seeking response patterns across children with autism spectrum disorder and developmental delay. Thus, although attentional disruptions may be unique to autism spectrum disorder, sensory disruptions appear across developmental delay and are associated with atypical sensory behaviors.

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