Factors influencing local tumour progression after radiofrequency ablation of malignant liver tumours

Purpose To determine negative predictive value (NPV) of contrast-enhanced ultrasound (CEUS) to demonstrate local tumour progression (LTP) at thermal ablation (TA) sites. Methods Our institutional review board approved this retrospective study; acquisition of consent was waived. Consecutive CEUS examinations performed between 2004-2014 for TA site evaluation on patients who could not undergo enhanced computed tomography (CT) or magnetic resonance imaging (MRI), or had inconclusive CT or MRI, were retrospectively reviewed. Those reported as no abnormal enhancement in or surrounding TA site were included. CEUS examination was considered true-negative based on stability or lack of enhancement/washout on follow-up imaging for at least 1 year, and false-negative (FN), if there was an arterially enhancing focus with wash-out at or surrounding TA site on subsequent follow-up imaging. Results Study population included 56 tumours in 54 patients, 11 women, 43 men; mean age 71 years. Two patients had TA of two different hepatocellular carcinomas. Thirty-six examinations were for hepatic TA and twenty for renal TA. Lesion sizes ranged from 1 cm to 7 cm (mean 3.1 ± 1.2). Mean diameter of 7 recurrences was 13.8 mm. Overall FN rate was 12.5% (7/56). Corresponding numbers were 0% (0/20) for renal TA and 19.4% (7/36) for hepatic TA. Overall NPV of CEUS was 87.5% (49/56) (confidence interval [CI]: 78.8%–96.2%). NPV for renal TA was 100% (20/20) (CI: 100%–100%) and for hepatic TA 81.5% (29/36) (CI: 67.6 %–93.5%). Conclusion In this cohort, CEUS showed high NPV for exclusion of LTP at renal TA sites. NPV for hepatic TA sites was high but lower than renal TA.

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Predicting local tumour progression after ablation for colorectal liver metastases: CT-based radiomics of the ablation zone

European Journal of Radiology ◽

10.1016/j.ejrad.2021.109773 ◽

2021 ◽

pp. 109773

Author(s):

F.C.R. Staal ◽

M. Taghavi ◽

D.J. van der Reijd ◽

F.M. Gomez ◽

F. Imani ◽

...

Keyword(s):

Liver Metastases ◽

Colorectal Liver Metastases ◽

Tumour Progression ◽

Ablation Zone ◽

Local Tumour ◽

Local Tumour Progression

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High-frequency versus low-frequency microwave ablation in malignant liver tumours: evaluation of local tumour control and survival

International Journal of Hyperthermia ◽

10.1080/02656736.2016.1212107 ◽

2016 ◽

Vol 32 (8) ◽

pp. 868-875 ◽

Cited By ~ 5

Author(s):

Thomas J. Vogl ◽

Ahmad Hagar ◽

Nour-Eldin A. Nour-Eldin ◽

Tatjana Gruber-Rouh ◽

Katrin Eichler ◽

...

Keyword(s):

High Frequency ◽

Microwave Ablation ◽

Low Frequency ◽

Liver Tumours ◽

Tumour Control ◽

Local Tumour Control ◽

Local Tumour ◽

Malignant Liver

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Long-Term Outcomes in Percutaneous Radiofrequency Ablation for Histologically Proven Colorectal Lung Metastasis

CardioVascular and Interventional Radiology ◽

10.1007/s00270-020-02623-1 ◽

2020 ◽

Vol 43 (12) ◽

pp. 1900-1907 ◽

Cited By ~ 1

Author(s):

Jim Zhong ◽

Ebrahim Palkhi ◽

Helen Ng ◽

Kevin Wang ◽

Richard Milton ◽

...

Keyword(s):

Prognostic Factors ◽

Radiofrequency Ablation ◽

Lung Metastasis ◽

Lung Metastases ◽

Tumour Progression ◽

Colorectal Metastases ◽

Long Term Outcome ◽

Colorectal Lung Metastases ◽

Local Tumour

Abstract Introduction To evaluate the long-term outcome of image-guided radiofrequency ablation (RFA) when treating histologically confirmed colorectal lung metastasis in terms of overall survival (OS), progression-free survival (PFS) and local tumour control (LTC). Materials and Methods Retrospective single-centre study. Consecutive RFA treatments of histologically proven lung colorectal metastases between 01/01/2008 and 31/12/14. The primary outcome was patient survival (OS and PFS). Secondary outcomes were local tumour progression (LTP) and complications. Prognostic factors associated with OS/ PFS were determined by univariate and multivariate analyses. Results Sixty patients (39 males: 21 females; median age 69 years) and 125 colorectal lung metastases were treated. Eighty percent (n = 48) also underwent lung surgery for lung metastases. Mean metastasis size (cm) was 1.4 ± 0.6 (range 0.3–4.0). Median number of RFA sessions was 1 (1–4). During follow-up (median 45.5 months), 45 patients died (75%). The estimated OS and PFS survival rates at 1, 3, 5, 7, 9 years were 96.7%, 74.7%, 44.1%, 27.5%, 16.3% (median OS, 52 months) and 66.7%, 31.2%, 25.9%, 21.2% and 5.9% (median PFS, 19 months). The LTC rate was 90% with 6 patients developing LTP with 1-, 2-, 3- and 4-year LTP rates of 3.3%, 8.3%, 10.0% and 10.0%. Progression-free interval < 1 year (P = 0.002, HR = 0.375) and total number of pulmonary metastases (≥ 3) treated (P = 0.037, HR = 0.480) were independent negative prognostic factors. Thirty-day mortality rate was 0% with no intra-procedural deaths. Conclusion The long-term OS and PFS following RFA for the treatment of histologically confirmed colorectal lung metastases demonstrate comparable oncological durability to surgery.

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Image-guided laser ablation in the treatment of recurrence of renal tumours: technique and preliminary results

European Radiology Experimental ◽

10.1186/s41747-019-0127-0 ◽

2020 ◽

Vol 4 (1) ◽

Cited By ~ 4

Author(s):

Federica Ferrari ◽

Giovanni Mauri ◽

Luca Nicosia ◽

Gianluca Maria Varano ◽

Guido Bonomo ◽

...

Keyword(s):

Laser Ablation ◽

Tumour Progression ◽

Invasive Treatment ◽

Clinical Role ◽

Illumination Time ◽

Image Guided ◽

Contrast Enhanced Ct ◽

Ultrasound Computed Tomography ◽

Local Tumour ◽

Local Tumour Progression

AbstractAbdominal recurrences of renal cell carcinoma (RCC) after surgery might represent a challenge for treatment, often requiring difficult surgeries or anticipated systemic therapy. Our aim is to illustrate a novel application of laser ablation for the treatment of abdominal recurrences of RCC. Patients with abdominal recurrences of renal cancer were treated under ultrasound/computed tomography guidance with a diode laser inserted into the lesion through a thin 21-G needle. A fixed 3-W power protocol was used, changing the illumination time according to lesion dimension and shape. Also, technical success, technical efficacy, local tumour progression, and major and minor complications were retrospectively analysed. Three patients were treated with image-guided laser ablation for abdominal recurrences of RCC. In all cases, it was possible to perform ablation as preoperatively planned and all three nodules (size of 6, 8, and 12 mm) were completely ablated with no evidence of residual enhancement after 6 weeks at contrast-enhanced CT. No minor or major complications were observed. No local tumour progression was reported up to 12 months from ablation. Image-guided laser ablation holds the potential to offer a minimally invasive treatment to patients with abdominal recurrence of RCC. Further studies are needed to evaluate the clinical role of this technique.

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