scholarly journals Trombosis pada corona virus disease (COVID-19)

2020 ◽  
Vol 20 (3) ◽  
Author(s):  
Agus Jati Sunggoro ◽  
Ibnu Purwanto ◽  
Maryatun Hasan
Keyword(s):  
Risk Assessment ◽  
Global Health ◽  
Health Problem ◽  
Recent Literature ◽  
Virus Disease ◽  
Morbidity And Mortality ◽  
Corona Virus ◽  
Risk Assessment And Management ◽  
Global Health Problem

Abstrak. Coronavirus Disease 2019 (COVID-19) telah menyebabkan masalah kesehatan di seluruh dunia dengan morbiditas dan mortalitas yang terus meningkat. Pada beberapa kasus COVID-19 diketahui terjadi manifestasi trombotik. Adanya kelainan trombotik ini tentunya mempengaruhi tatalaksana dan prognosis pasien COVID-19. Oleh karena itu penting untuk mengetahui patofisiologi dan manajemen trombosis pada COVID-19. Tujuan dari artikel ini adalah mengulas literatur terbaru terkait prevalensi, patofisiologi, penilaian risiko, serta manajemen trombosis pada COVID-19.Kata kunci: COVID-19, trombosis.Abstract. Coronavirus Disease 2019 (COVID-19) has become a global health problem with ever increasing morbidity and mortality. In some cases, thrombotic manifestation has been reported in COVID-19 patients. This thrombotic manifestation certainly affects the management and prognosis of COVID-19 patients. Therefore it is crucial to understand the pathophysiology and management of thrombosis in COVID-19. The aim of this article is to review the recent literature regarding prevalence, pathophysiology, risk assessment, and management of thrombosis in COVID-19.Keywords:COVID-19, thrombosis

Complications of diabetes: beyond the heart, kidneys, and eyes

2019 ◽  
pp. 23-27
Keyword(s):  
Risk Factors ◽  
Global Health ◽  
Health Problem ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Complications Of Diabetes ◽  
Organ Systems ◽  
Global Health Problem

Diabetes is a leading global health problem. Clinicians and most patients are aware that diabetes can lead to complications in the heart, kidneys, and eyes. Given the high morbidity and mortality, much effort is made to screen for and treat these complications. Other organ systems can also be affected by diabetes. The pathogenesis and risk factors for developing these other complications does not always match those for heart, kidneys, and eyes. Additionally, treatment for these other complications is often limited or absent. Here we will review some of the major musculoskeletal, neuropathic, and skin complications linked to diabetes.

scholarly journals Osmium–arene complexes with high potency towards Mycobacterium tuberculosis

Metallomics ◽  
2021 ◽  
Vol 13 (4) ◽  
Author(s):  
James P C Coverdale ◽  
Collette S Guy ◽  
Hannah E Bridgewater ◽  
Russell J Needham ◽  
Elizabeth Fullam ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Global Health ◽  
Mechanism Of Action ◽  
Health Problem ◽  
Normal Lung ◽  
Lung Cells ◽  
Redox Mechanism ◽  
Human Lung Cells ◽  
Half Sandwich ◽  
Global Health Problem

Abstract The treatment of tuberculosis (TB) poses a major challenge as frontline therapeutic agents become increasingly ineffective with the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). To combat this global health problem, new antitubercular agents with novel modes of action are needed. We have screened a close family of 17 organometallic half-sandwich Os(II) complexes [(arene)Os(phenyl-azo/imino-pyridine)(Cl/I)]+Y– containing various arenes (p-cymene, biphenyl, or terphenyl), and NMe2, F, Cl, or Br phenyl or pyridyl substituents, for activity towards Mtb in comparison with normal human lung cells (MRC5). In general, complexes with a monodentate iodido ligand were more potent than chlorido complexes, and the five most potent iodido complexes (MIC 1.25–2.5 µM) have an electron-donating Me2N or OH substituent on the phenyl ring. As expected, the counter anion Y (PF6–, Cl–, I–) had little effect on the activity. The pattern of potency of the complexes towards Mtb is similar to that towards human cells, perhaps because in both cases intracellular thiols are likely to be involved in their activation and their redox mechanism of action. The most active complex against Mtb is the p-cymene Os(II) NMe2-phenyl-azopyridine iodido complex (2), a relatively inert complex that also exhibits potent activity towards cancer cells. The uptake of Os from complex 2 by Mtb is rapid and peaks after 6 h, with temperature-dependence studies suggesting a major role for active transport. Significance to Metallomics Antimicrobial resistance is a global health problem. New advances are urgently needed in the discovery of new antibiotics with novel mechanisms of action. Half-sandwich organometallic complexes offer a versatile platform for drug design. We show that with an appropriate choice of the arene, an N,N-chelated ligand, and monodentate ligand, half-sandwich organo–osmium(II) complexes can exhibit potent activity towards Mycobacterium tuberculosis (Mtb), the leading cause of death from a single infectious agent. The patterns of activity of the 17 azo- and imino-pyridine complexes studied here towards Mtb and normal lung cells suggest a common redox mechanism of action involving intracellular thiols.

Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity

2021 ◽  
Vol 141 ◽  
pp. 243-254
Author(s):  
Sila Ozlem Sener ◽  
Ufuk Ozgen ◽  
Seyda Kanbolat ◽  
Nuriye Korkmaz ◽  
Merve Badem ◽  
...  
Keyword(s):  
Global Health ◽  
Health Problem ◽  
Therapeutic Potential ◽  
Global Health Problem

Principles of risk assessment and risk management

2013 ◽  
Author(s):  
Julia Smedley ◽  
Finlay Dick ◽  
Steven Sadhra
Keyword(s):  
Risk Assessment ◽  
Risk Management ◽  
Risk Communication ◽  
Conceptual Model ◽  
Health Problem ◽  
Scientific Evidence ◽  
Risks And Benefits ◽  
Societal Level ◽  
Risk Assessment And Management ◽  
P Sources

Introduction and terminology 416Conceptual model 417General principles 418Sources of scientific evidence and uncertainty 420Risk communication and perception 421Decisions in OH often entail a choice between two or more options, the comparative merits of which are not immediately obvious. The decision may be for an individual (e.g. whether to ground a pilot because of a health problem), for the whole of a workforce (e.g. whether to immunize HCWs against smallpox), or at a societal level (e.g. whether to permit the use of a pesticide). Risk management is the process by which decisions of this sort are made, following an assessment of the risks and benefits associated with each option. Depending on the nature of the decision, the process of risk assessment and management may be more or less formalized....

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