Novelties in evaluation and monitoring of HIV-1 infection:  Is standard virological suppression enough for measuring antiretroviral treatment success?

AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of “90-90-90” to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase the emergence and spreading of HIV drug resistance and current HIV drug resistance test (DRT) assays in China are seriously lagging behind, hindering to achieve virological suppression. Therefore, recommending an appropriate HIV DRT method is critical for HIV routine surveillance and prevention in China. In this review, we summarized the current existing HIV drug resistance genotypic testing methods around the world and discussed the advantages and disadvantages of these methods.

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Clade homogeneity and Pol gene polymorphisms in chronically HIV-1 infected antiretroviral treatment naive patients after the roll out of ART in Ethiopia

BMC Infectious Diseases ◽

10.1186/1471-2334-14-158 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 10

Author(s):

Andargachew Mulu ◽

Thomas Lange ◽

Uwe Gerd Liebert ◽

Melanie Maier

Keyword(s):

Gene Polymorphisms ◽

Antiretroviral Treatment ◽

Treatment Naïve ◽

Hiv 1 ◽

Roll Out

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Plasma Cytokine Levels in Tanzanian HIV-1-Infected Adults and the Effect of Antiretroviral Treatment

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/qai.0b013e3181b627dc ◽

2009 ◽

Vol 52 (4) ◽

pp. 493-497 ◽

Cited By ~ 29

Author(s):

Judith M Haissman ◽

Lasse S Vestergaard ◽

Samuel Sembuche ◽

Christian Erikstrup ◽

Bruno Mmbando ◽

...

Keyword(s):

Antiretroviral Treatment ◽

Plasma Cytokine ◽

Cytokine Levels ◽

Hiv 1

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Variation in antiretroviral treatment coverage and virological suppression among three HIV key populations

AIDS ◽

10.1097/qad.0000000000002035 ◽

2018 ◽

Vol 32 (18) ◽

pp. 2807-2819 ◽

Cited By ~ 5

Author(s):

Kamilla Grønborg Laut ◽

Leah Shepherd ◽

Magnus Gottfredsson ◽

Dalibor Sedlacek ◽

Brygida Knysz ◽

...

Keyword(s):

Antiretroviral Treatment ◽

Virological Suppression ◽

Key Populations ◽

Treatment Coverage

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Acute Human Immunodeficiency Virus (HIV) Infection Presenting With Bilateral Interstitial Pneumonia: Case Report and Discussion of Potential HIV-Induced Interstitial Pneumonia

Open Forum Infectious Diseases ◽

10.1093/ofid/ofx256 ◽

2017 ◽

Vol 4 (4) ◽

Author(s):

Anna Maria Peri ◽

Laura Alagna ◽

Serena Trovati ◽

Francesca Sabbatini ◽

Roberto Rona ◽

...

Keyword(s):

Intensive Care Unit ◽

Human Immunodeficiency Virus ◽

Intensive Care ◽

Case Report ◽

Interstitial Pneumonia ◽

Antiretroviral Treatment ◽

Pneumonia Case ◽

Immunodeficiency Virus ◽

Acute Hiv ◽

Hiv 1

Abstract A 50-year-old man was admitted to intensive care unit because of acute respiratory failure due interstitial pneumonia; after admission, a diagnosis of acute human immunodeficiency virus (HIV)-1 infection was made. Clinical and radiological improvement was observed only after introduction of antiretroviral treatment. We discuss the hypothesis of interstitial pneumonia induced by the acute HIV-1 infection.

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