Antimicrobial photodynamic therapy in voice rehabilitation of patients after laryngectomy

The article is devoted to the problem of voice rehabilitation of patients after laryngectomy. Modern possibilities of repairing laryngeal vocal function, methods for extending the lifetime of voice prostheses are considered. The author’s method of prevention of infection of vocal prostheses using the antimicrobial photodynamic therapy (PDT) with chlorin-type photosensitizer Radagel is presented. Performing antimicrobial PDT of vocal prostheses increased the average operating time to 11.9 months compared to the control group (6.8 months), where a monthly dose of 150 mg of fluconazole was used for prevention. The method developed by the authors makes it possible to significantly extend the lifetime of vocal prostheses, is devoid of adverse events, is well tolerated by patients.

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Minilaparotomy Cholecystectomy as a Day Surgery Procedure: A Prospective Clinical Pilot Study

Scandinavian Journal of Surgery ◽

10.1177/145749690709600304 ◽

2007 ◽

Vol 96 (3) ◽

pp. 206-208 ◽

Cited By ~ 8

Author(s):

J. Harju ◽

M. Pääkkönen ◽

M. Eskelinen

Keyword(s):

Randomised Trial ◽

Operating Time ◽

Day Surgery ◽

Prospective Randomised Trial ◽

Wound Pain ◽

Average Operating ◽

Average Operating Time ◽

Study Support ◽

The Mean

Background and Aims: In some studies minilaparotomy cholecystectomy (MC) has been shown to be as good as laparoscopic cholecystectomy (LC) in the surgical treatment of cholecystolithiasis. To our knowledge, the MC operation is rarely considered as a day surgery procedure. Patients and Methods: Thirty elective symptomatic non-complicated patients were included in the study during the end of the year 2004 to June 2005. The mean age of patients was 52 years (range 27–68), the mean body mass index 29 kg/m2 (range 19–41). Gallstones were confirmed with ultrasound and the pre-operative liver laboratory tests were normal in all patients. A five (+/-2) centimetre-long incision was used avoiding to split the rectus abdominis muscle. All patients were re-evaluated four weeks postoperatively with the follow-up letter. Results: The average operating time was 51 minutes (range 30–105 minutes). Day surgery was possible in 25 cases (83%). Five patients (17%) stayed over night at the hospital. There were four (13%) conversions to conventional cholecystectomy. The average postoperative sick leave was 16 days (range 14–30). Two patients returned to hospital. One patient had wound pain, but no complication was found, and the patient was not admitted. One patient had a wound infection and spent 6 days in the hospital. Twenty-nine (97%) patients were satisfied with the operation and were ready to recommend it for other patients. Conclusions: The results of this study support the suitability of MC as a day surgery procedure, but a prospective randomised trial is needed to evaluate the relative advantages of MC and LC.

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Video assisted resections. Increasing access to minimally invasive liver surgery?

Revista do Colégio Brasileiro de Cirurgiões ◽

10.1590/0100-69912015005009 ◽

2015 ◽

Vol 42 (5) ◽

pp. 318-324 ◽

Cited By ~ 2

Author(s):

Fabricio Ferreira Coelho ◽

Marcos Vinícius Perini ◽

Jaime Arthur Pirola Kruger ◽

Renato Micelli Lupinacci ◽

Fábio Ferrari Makdissi ◽

...

Keyword(s):

Operating Time ◽

Perioperative Outcomes ◽

Liver Lesions ◽

Minimally Invasive Liver Surgery ◽

Video Assisted ◽

Average Operating ◽

Average Operating Time ◽

Average Size ◽

Anesthesia Time ◽

Prospective Database

Objective: To evaluate perioperative outcomes, safety and feasibility of video-assisted resection for primary and secondary liver lesions. Methods : From a prospective database, we analyzed the perioperative results (up to 90 days) of 25 consecutive patients undergoing video-assisted resections in the period between June 2007 and June 2013. Results : The mean age was 53.4 years (23-73) and 16 (64%) patients were female. Of the total, 84% were suffering from malignant diseases. We performed 33 resections (1 to 4 nodules per patient). The procedures performed were non-anatomical resections (n = 26), segmentectomy (n = 1), 2/3 bisegmentectomy (n = 1), 6/7 bisegmentectomy (n = 1), left hepatectomy (n = 2) and right hepatectomy (n = 2). The procedures contemplated postero-superior segments in 66.7%, requiring multiple or larger resections. The average operating time was 226 minutes (80-420), and anesthesia time, 360 minutes (200-630). The average size of resected nodes was 3.2 cm (0.8 to 10) and the surgical margins were free in all the analyzed specimens. Eight percent of patients needed blood transfusion and no case was converted to open surgery. The length of stay was 6.5 days (3-16). Postoperative complications occurred in 20% of patients, with no perioperative mortality. Conclusion : The video-assisted liver resection is feasible and safe and should be part of the liver surgeon armamentarium for resection of primary and secondary liver lesions.

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The Effect of Antimicrobial Photodynamic Therapy Using Chlorophyllin–Phycocyanin Mixture on Enterococcus faecalis: The Influence of Different Light Sources

Applied Sciences ◽

10.3390/app10124290 ◽

2020 ◽

Vol 10 (12) ◽

pp. 4290 ◽

Cited By ~ 4

Author(s):

Nasim Chiniforush ◽

Maryam Pourhajibagher ◽

Steven Parker ◽

Stefano Benedicenti ◽

Abbas Bahador ◽

...

Keyword(s):

Photodynamic Therapy ◽

Diode Laser ◽

Enterococcus Faecalis ◽

Control Group ◽

Human Gingival Fibroblast ◽

Light Sources ◽

Gingival Fibroblast ◽

Antimicrobial Photodynamic Therapy ◽

Cell Viability Assay ◽

Vitro Effect

The purpose of this study was to evaluate the in vitro effect of the chlorophyllin–phycocyanin mixture (Photoactive+) as a photosensitizer (PS) during antimicrobial photodynamic therapy (aPDT) on the count of Enterococcus faecalis (E. faecalis) using different light sources. The antimicrobial effect of aPDT with chlorophyllin–phycocyanin mixture using different light sources including diode laser (λ = 660 nm), diode laser (λ = 635 nm), LED (λ = 450 ± 30 nm) alone or in combination was assessed using microbial cell viability assay against E. faecalis. In addition, the cell cytotoxicity of Photoactive+ was assessed on human gingival fibroblast (HuGu) cells by MTT assay; E. faecalis growth when treated by both red wavelengths (635 nm, 660 nm) and combination of LED (420–480 nm) and red wavelengths (635 nm, 660 nm), significantly reduced compared to the control group (p < 0.05). There was no significant reduction in the number of viable cells exposed to Photoactive+ compared to the control group (p < 0.05). This study shows that the application of chlorophyllin–phycocyanin mixture and irradiation with emission of red light achieved a better result for bacterial count reduction, compared to a control. This component can be applied safely due to very negligible cytotoxicity.

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Enhanced Reduction of Polymicrobial Biofilms on the Orthodontic Brackets and Enamel Surface Remineralization Using Zeolite-Zinc Oxide Nanoparticles-Based Antimicrobial Photodynamic Therapy

10.21203/rs.3.rs-498528/v1 ◽

2021 ◽

Author(s):

Maryam Pourhajibagher ◽

Abbas Bahador

Keyword(s):

Zinc Oxide ◽

Photodynamic Therapy ◽

Zinc Oxide Nanoparticles ◽

Enamel Surface ◽

Orthodontic Brackets ◽

Control Group ◽

Oxide Nanoparticles ◽

Antimicrobial Photodynamic Therapy ◽

Diagnodent Pen ◽

Metabolic Activities

Abstract The aim of this study was to evaluate the anti-biofilm and anti-metabolic activities of zeolite-zinc oxide nanoparticles (Zeo\ZnONPs)-based antimicrobial photodynamic therapy (aPDT) against pre-formed polymicrobial biofilms on the orthodontic brackets, as well as, assess the remineralization efficacy on polymicrobial biofilms induced enamel lesions. Following synthesis and characterization of Zeo\ZnONPs, cell cytotoxicity, hemolytic effect, and intracellular reactive oxygen species (ROS) production were determined. The anti-biofilm and anti-metabolic activities of aPDT using different concentrations of Zeo\ZnONPs were investigated. Microhardness tester and DIAGNOdent Pen were used to evaluate the changes of remineralization degree on the treated enamel slabs duration one and three months. No significant cytotoxicity and erythrocyte hemolysis were observed in treated cells with Ze\ZnONPs. When irradiated, suggesting that the Ze\ZnONPs were photoactivated, generating ROS and leading to reduce dose-dependently the cell viability and metabolic activity of polymicrobial biofilms. Also, the enamel surface microhardness value of exposed enamel showed a steady increase with the concentration of Zeo\ZnONPs. No statistically significant differences were shown between aPDT and sodium fluoride varnish as the control group. Overall, Zeo\ZnONPs-based aPDT with the greatest remineralization efficacy of enamel surface can be used as an anti-biofilm therapeutic method, which is involved with their potent ability to produce ROS.

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Laparoscopic “en-bloc” ligation of spermatic veins

Urologia Journal ◽

10.1177/039156039606300322 ◽

1996 ◽

Vol 63 (3) ◽

pp. 384-388

Author(s):

C. Trombetta ◽

G. Savoca ◽

G. Liguori ◽

A. Tamai ◽

S. Siracusano ◽

...

Keyword(s):

General Anaesthesia ◽

Operating Time ◽

Case Histories ◽

En Bloc ◽

Optical Magnification ◽

Average Operating ◽

Average Operating Time ◽

The Right

Laparoscopic varicocelectomy is suggested only for II-III grade bilateral varicocele. The optical magnification granted by videosurgical techniques, prevents damaging testicular arteries; this possibility, however, requires a considerable amount of time. We performed a laparoscopic “en-bloc” ligation without sparing the artery on 13 patients with bilateral varicocele in order to assess eventual changes in gonadal volume. 10 patients underwent bilateral “en-bloc” ligation of spermatic vessels with an average operating time of 21 minutes. In 3 other patients, “en-bloc” ligation was performed on the right side while on the left side the artery was identified and saved; in these cases the average operating time was 33 minutes. After an average follow-up period of 19 months no cases of testicle atrophy nor of hydrocele were reported. ColorDoppler sonography, performed 3 months later on the 10 patients treated by bilateral “en-bloc” ligation, showed no persistent reflux. No case of homolateral persistent reflux was encountered in the 3 patients who underwent only right-side “en-bloc” ligation, but on the left side, where selective ligation had been performed, persistence of reflux was registered in one patient. Our experience has confirmed that laparoscopic “en-bloc” ligation of the internal spermatic pedicle, sparing vasa deferentia, prevents the persistence of reflux in all cases and allows a reduction in operating time. The opportunity of treating a pathology like bilateral varicocele by means of laparoscopy, which requires general anaesthesia, needs further confirmation and a larger number of case histories.

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Laparoscopic Adrenalectomy for Adrenal Tumors

International Journal of Endocrinology ◽

10.1155/2014/241854 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 8

Author(s):

Sun Chuan-yu ◽

Ho Yat-faat ◽

Ding Wei-hong ◽

Gou Yuan-cheng ◽

Hu Qing-feng ◽

...

Keyword(s):

Blood Loss ◽

Laparoscopic Adrenalectomy ◽

Benign Tumor ◽

Operating Time ◽

Adrenal Tumors ◽

Benign Tumors ◽

Intraoperative Blood Loss ◽

First Choice ◽

Average Operating ◽

Average Operating Time

Objective. To evaluate the indication and the clinical value of laparoscopic adrenalectomy of different types of adrenal tumor.Methods. From 2009 to 2014, a total of 110 patients were diagnosed with adrenal benign tumor by CT scan and we performed laparoscopic adrenalectomy. The laparoscopic approach has been the procedure of choice for surgery of benign adrenal tumors, and the upper limit of tumor size was thought to be 6 cm.Results. 109 of 110 cases were successful; only one was converted to open surgery due to bleeding. The average operating time and intraoperative blood loss of pheochromocytoma were significantly more than the benign tumors (P<0.05). After 3 months of follow-up, the preoperative symptoms were relieved and there was no recurrence.Conclusions. Laparoscopic adrenalectomy has the advantages of minimal invasion, less blood loss, fewer complications, quicker recovery, and shorter hospital stay. The full preparation before operation can decrease the average operating time and intraoperative blood loss of pheochromocytomas. Laparoscopic adrenalectomy should be considered as the first choice treatment for the resection of adrenal benign tumor.

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EFFICACY OF PHOTODYNAMIC THERAPY AS AN ADJUNCT TO NON – SURGICAL PERIODONTAL THERAPY IN TYPE-2 DIABETES MELLITUS PATIENT

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v6i1.2383 ◽

2022 ◽

Vol 6 (1) ◽

Author(s):

Roshni Ghosh ◽

Pradeep Shukla ◽

Gaurav Malhotra ◽

Prerna Kataria ◽

Preeti Shukla ◽

...

Keyword(s):

Photodynamic Therapy ◽

Control Group ◽

Diabetic Patients ◽

Antimicrobial Photodynamic Therapy ◽

Scaling And Root Planing ◽

Root Planing ◽

Probing Depth ◽

The Mean ◽

Attachment Level

Background: To Evaluate the additional benefit of Antimicrobial Photodynamic therapy, if any in the glycemic control of type 2 diabetes mellitus chronic periodontitis patients . Methods: Fifty diabetic patients with chronic periodontitis were taken for the study who met the inclusion criteria of clinical attachment loss ?3 to 5 mm at ? 30% of sites and bleeding on probing present in two different quadrants . After SRP ( Scaling and root planing ) , one quadrant was selected for aPDT while other served as a control group. Clinical parameters i.e. Plaque index, Probing depth ,Relative attachment level and HBA1c were measured at baseline, 1 week , 1month and 3 months. Results: Statistically significant differences in the mean probing depth, Relative attachment level, plaque deposit, and HBA1c were found between baseline and 12 weeks post-treatment for both groups. No significant differences in glucose levels were detected among the two groups in 1 week . Reduction in the mean HbA1c level after treatment was observed in both groups in 1 month and 3 months . Conclusion: Antimicrobial Photodynamic Therapy when used in addition to scaling and root planing yields significant improvement of mean probing depth , Plaque deposit ,Relative attachment levels, periodontal status and reduction of HbA1c levels in treatment of diabetic patients with periodontitis when comparing the test group to the control group. Keywords: photodynamic therapy , scaling and root planing, glycated haemoglobin ,Randomized controlled trial

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URBAN PUBLIC TRANSPORT: MARGINAL VALUE OF THE CAPACITY FACTOR

The Russian Automobile and Highway Industry Journal ◽

10.26518/2071-7296-2019-3-290-301 ◽

2019 ◽

Vol 16 (3) ◽

pp. 290-301

Author(s):

A. I. Fadeev ◽

Ye. V. Fomin ◽

S. Alhusseini

Keyword(s):

Public Transport ◽

Operating Time ◽

Capacity Utilization ◽

Utilization Factor ◽

Marginal Value ◽

Passenger Traffic ◽

Urban Public Transport ◽

Speed Fluctuation ◽

Average Operating ◽

Average Operating Time

Introduction. One of the most important indicators determining the public transport service quality is the capacity utilization factor of transport fleet. This parameter directly effects on the economic efficiency of the transport organization. For the carrier it is desirable from an economic point of view that the value of the capacity utilization factor takes on the greatest value. Passengers, on the contrary, prefer to transfer without overfull capacity of transport vehicles. Moreover, this factor is used in determining travel fares, analyzing the executed movement regarding the availability of reserves in carrying capacity and planning transportation process. The paper discusses the method of marginal value calculation of the transport fleet’s capacity utilization factor of urban public transport based on ensuring standard vehicle's cabin filling limits.Materials and methods. The authors solved the task of determining the filling marginal value for transport fleet while working on regular urban routes by analyzing the dependence of the capacity utilization factor on the passenger traffic parameters, the average operating time of the transport fleet on the route and the speed fluctuation during public transport operation. The authors also proposed the indicator of the transportation speed fluctuation during the operation of urban public transport.Results. The authors found out that the capacity utilization factor of transport fleet substantially depended on the passenger traffic parameters, on the average operating time of the transport fleet and on the speed fluctuation during public transport operation.Discussion and conclusion. The obtained dependences allow us calculating the marginal values of capacity utilization factor with taking into account the parameters of the planned transport process. The standard capacity utilization factor varies within considerable limits from 0.2 to 0.4, depending on the operating conditions.

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833 Hyper Acute Dialysis Access Pathway (HADAP) – Undertaking Creation of Arteriovenous Fistulae in The Renal Ward

British Journal of Surgery ◽

10.1093/bjs/znab135.004 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

S Shetty ◽

P Chowdary ◽

D Dabare ◽

C Seet ◽

R Ahmed ◽

...

Keyword(s):

Operating Time ◽

Surgical Site Infections ◽

Primary Patency ◽

Successful Implementation ◽

Dialysis Access ◽

Arteriovenous Fistulae ◽

Surgical Assistance ◽

Average Operating ◽

Average Operating Time ◽

Duration Of Operation

Abstract Introduction The impetus to apply the “lean method” to creation of arteriovenous fistulae came with the pandemic restricting access to theatres. Here we present HADAP implemented in a dedicated procedure room in the Renal ward. Method Between April and September 2020, 44 patients underwent ward-based arteriovenous fistula operations with no more than 3 people in the room – surgeon, runner and patient. The parameters assessed were duration of operation, complications, patency, patient and surgeon feedback and financial implications. Results The service was predominantly registrar-led who created 91% of the fistulae. 95% operations were completed successfully with a 2-week primary patency of 73% and no surgical site infections. 40% of the procedures were radiocephalic fistulae. 14% procedures required surgical assistance by the runner. The average operating time reduced from 90 minutes for the first 10 cases to 50 minutes for the last 9. A structured questionnaire showed positive feedback from both patients and surgeons (4-5 out of 5). This service has cleared potentially 9 main theatre lists for more complex procedures. Conclusions Our study demonstrates the successful implementation of a novel operating environment allowing expedited care for renal failure patients. It has enhanced our ability to deliver a dialysis access program despite the challenges of COVID.

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Surrenectomia laparoscopica: Nostra esperienza

Urologia Journal ◽

10.1177/039156039706401s19 ◽

1997 ◽

Vol 64 (1_suppl) ◽

pp. 74-77

Author(s):

F. Porpiglia ◽

M. Morino ◽

C. Garrone ◽

M. Terzolo ◽

I. Morra ◽

...

Keyword(s):

Autologous Blood ◽

Operating Time ◽

Oral Intake ◽

Average Hospital Stay ◽

Average Hospital ◽

Post Operative Period ◽

Alternative Approach ◽

Estimated Blood Loss ◽

Average Operating ◽

Average Operating Time

Laparoscopy has been described as an alternative approach for performing adrenalectomy. From January ‘96 to April ‘97, 14 laparoscopie adrenalectomies were performed in our Division. Patient age ranged from 33 to 64 years. The clinical diagnosis included 5 Conn's syndrome, 3 pheochromocytoma, 3 Cushing's syndrome, 1 Cushing's disease and 3 incidentalomas. Average operating time was 70’ and 90’ for right and left adrenalectomy respectively. The average estimated blood loss was 70 ml. All the patients resumed oral intake antalgic therapy with Ketorolac in the first 12 post-operative hours. The patients resumed oral intake within 1 day. Two patients received 500 ml of autologous blood in the post-operative period. The average hospital stay was 3.5 days. These results suggest that laparoscopie adrenalectomy is a minimally invasive alternative to traditional open adrenalectomy.

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