scholarly journals EFFICACY OF PHOTODYNAMIC THERAPY AS AN ADJUNCT TO NON – SURGICAL PERIODONTAL THERAPY IN TYPE-2 DIABETES MELLITUS PATIENT

2022 ◽  
Vol 6 (1) ◽  
Author(s):  
Roshni Ghosh ◽  
Pradeep Shukla ◽  
Gaurav Malhotra ◽  
Prerna Kataria ◽  
Preeti Shukla ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Control Group ◽  
Diabetic Patients ◽  
Antimicrobial Photodynamic Therapy ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Probing Depth ◽  
The Mean ◽  
Attachment Level

Background: To Evaluate the additional benefit of Antimicrobial Photodynamic therapy, if any in the glycemic control of type 2 diabetes mellitus  chronic periodontitis patients . Methods:  Fifty  diabetic patients with chronic periodontitis were taken for the study who met the inclusion criteria of clinical attachment loss ?3 to 5 mm at ? 30% of sites and bleeding on probing present in two different quadrants . After SRP ( Scaling and root planing ) , one quadrant was selected for aPDT while other served as a control group. Clinical parameters i.e. Plaque index, Probing depth ,Relative attachment level and HBA1c were measured at baseline, 1 week , 1month and 3 months. Results: Statistically significant differences in the mean probing depth, Relative attachment level, plaque deposit, and HBA1c were found between baseline and 12 weeks post-treatment for both groups. No significant differences in glucose levels were detected among the two  groups in 1 week . Reduction in the mean HbA1c level after treatment was observed in both groups in 1 month and 3 months . Conclusion:  Antimicrobial Photodynamic Therapy when used in addition to scaling and root planing yields significant improvement of  mean probing depth , Plaque deposit ,Relative attachment levels,  periodontal status and reduction of HbA1c levels in treatment of diabetic patients with periodontitis when comparing the test group to the control group. Keywords: photodynamic therapy , scaling and root planing, glycated haemoglobin ,Randomized controlled trial

scholarly journals Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

2016 ◽  
Vol 9 (5) ◽  
pp. 234
Author(s):  
Zahra Heidari ◽  
Zahra Sepehri ◽  
Aleme Doostdar
Keyword(s):  
Type 2 Diabetes ◽  
Serum Level ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetes Incidence ◽  
Serum Selenium ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
The Mean

<p>In addition to known risk factors, the role of different micronutrients such as selenium in diabetes incidence has been proposed. Some previous studies have shown an association of selenium deficiency and type 2 diabetes mellitus, while other studies have not confirmed such a relationship. The aim of this study was to evaluate serum level of selenium in patients with Type 2 diabetes compared with the control group. This cross-sectional study was carried out on patients with type 2 diabetes in Zahedan, southeastern Iran. One hundred newly diagnosed type 2 diabetic patients were evaluated for serum selenium level. One hundred subjects from the general population who had normal fasting blood sugar levels were selected as the control group. The control group subjects were matched in pairs with each of patients on the basis of sex, age (± one year), and body mass index (±1). Serum level of selenium was determined by spectrometry method. Results were compared using t-test. The mean serum level of selenium in patients was 94.47±18.07 µg/L whereas in control group was 142.79±23.67 µg/L. The mean serum level of selenium was significantly different between the two groups (P&lt;0.001). Serum levels of selenium in diabetic patients with significant difference statistically were lower than the control group. In order to evaluate serum level of selenium in patients with diabetes, studies with larger sample size are required. Likewise, prospective studies along with selenium supplementation and investigating its effect on incidence of diabetes are accordingly needed.</p>

scholarly journals The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes

2020 ◽  
Author(s):  
Fatemeh Haidari ◽  
Mehrnoosh Zakerkish ◽  
Fatemeh Borazjani ◽  
Kambiz Ahmadi Angali ◽  
Golnaz Amoochi
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Intervention Group ◽  
Gastrointestinal Symptoms ◽  
Control Group ◽  
Diabetic Patients ◽  
Anethum Graveolens ◽  
Type 2 Diabetic Patients ◽  
The Mean

Abstract Background: The objective of this study was to investigate the effects of anethum graveolens (dill) powder supplementation on glycemic control, lipid profile, some antioxidants and inflammatory markers, and gastrointestinal symptoms in type 2 diabetic patients. Material and methods: In this study, 42 patients with type 2 diabetes were randomly allocated to intervention and control groups and received either 3g/day dill powder or placebo (3 capsules/day, 1 g each). Fasting blood sugar (FBS), insulin, homeostatic model assessment of insulin resistance (HOMA- IR), lipid profile, hs-C-reactive protein (hs-CRP), total antioxidant capacity (TAC), malondialdehyde (MDA), and gastrointestinal symptoms were measured in all of the subjects at baseline and post-intervention. Results: The dill powder supplementation significantly decreased the mean serum levels of insulin, HOMA-IR, LDL-C, TC, and MDA in the intervention group in comparison with the baseline measurements (p < 0.05). Also, the mean serum levels of HDL and TAC were significantly increased in the intervention group in comparison with the baseline measurement (p < 0.05). Colonic motility disorder was the only gastrointestinal symptom whose frequency was significantly reduced by supplementation (P = 0.01). The mean changes of insulin, LDL-C , TC, and MDA were significantly lower in the intervention group than in the control group (p < 0.05). In addition, the mean changes in HDL were significantly higher in the intervention group than in the control group (p < 0.05). Conclusion: Dill powder supplementation can be effective in controlling the glycemic, lipid, stress oxidative, and gastrointestinal symptoms in type 2 diabetic patients. Keywords: Type 2 diabetes; Dill powder; Glycemic control; Lipid profile; Stress oxidative status

SHORT TERM EFFECTS OF PHOTODYNAMIC THERAPY ON CLINICAL, MICROBIAL AND BIOCHEMICAL PARAMETERS IN PATIENTS WITH CHRONIC PERIODONTITIS

2021 ◽  
pp. 1-4
Author(s):  
Akila Lingesan ◽  
Rajasekar Sundaram ◽  
Arularasi Aberna R ◽  
Sethupathy S ◽  
John William Felix A
Keyword(s):  
Photodynamic Therapy ◽  
Chronic Periodontitis ◽  
Biochemical Parameters ◽  
Rank Test ◽  
Target Cells ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Invasive Approach ◽  
Root Planing ◽  
The Mean

Objectives: Photodynamic therapy applies to the elimination of target cells by reactive oxygen species using a photosensitizing agent and a sufcient wavelength of light. It is a new, non-invasive approach to preventing infection. It is now an upcoming alternative treatment modality for periodontitis patients as a supplement to traditional scaling and root planing. The objective of the present study was to assess and compare the effect of photodynamic therapy with conventional Scaling and Root planing in patients with chronic periodontitis. Methods: The study included a minimum of 5 non-smoking males with mild to moderate periodontitis. Clinical parameters such as plaque index, gingival index, gingival bleeding index, pocket probing depth, clinical attachment level; microbiological parameter – anaerobic bacterial CFU count in subgingival plaque samples and biochemical parameter – GCF SOD levels were evaluated at baseline and 28 days postoperatively. The obtained data were analyzed using SPSS (SYSTAT 12) statistical software. The Wilcoxon signed Rank test was used to compare the mean values of various parameters before and after treatment. Results: The results of the study show that all clinical parameters improved from baseline to day 28. Following therapy, the mean levels of the anaerobic bacterial CFU and GCF SOD have decreased dramatically. Conclusion: The results of this study suggest a signicant improvement in clinical, microbiological and Biochemical parameters with the use of PDT as an adjunct to conventional SRP in chronic periodontitis patients

scholarly journals Laser Assisted Non-surgical Periodontal Therapy: A Double Blind, Randomized Clinical Trial

2017 ◽  
Vol 11 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Joseph D. Everett ◽  
Jeffrey A. Rossmann ◽  
David G. Kerns ◽  
Ibtisam Al-Hashimi
Keyword(s):  
Laser Therapy ◽  
Chronic Periodontitis ◽  
Test Group ◽  
Control Group ◽  
Scaling And Root Planing ◽  
Clinical Attachment Level ◽  
Laboratory Parameters ◽  
Root Planing ◽  
Significant Difference ◽  
Attachment Level

The objective of this study was to examine potential benefits of using laser therapy for secular decontamination in conjunction with scaling and root planing in the treatment of chronic periodontitis. The study was performed on 173 teeth in 14 patients in a split-mouth design, one side received scaling and root planing followed by laser therapy using a carbon dioxide (CO2) laser with an ablative handpiece (test group); the contralateral side received scaling and root planing without laser (control group). Clinical and laboratory parameters were evaluated prior to treatment and at 3 and 6 months following therapy; clinical measurements were performed by two blinded examiners. The clinical parameters included measurement of gingival recession (REC), bleeding on probing (BOP), clinical attachment level (CAL), pocket depth (PD), furcation involvement (FUR), and tooth mobility (MOB). Laboratory testing to determine the levels of periodontal pathogens was performed using PCR techniques. The results of the study revealed statistically significant differences in clinical and laboratory parameters at 3 and 6 months after therapy for both test and control groups, but no significant difference was observed between the two groups. However, sites receiving laser therapy tended to show a greater decrease in probing depths, gain in clinical attachment level, and reduced bacterial levels. In conclusion, the overall results of the study suggest a potential benefit of using laser therapy in conjunction with scaling and root planing for the treatment of chronic periodontitis.

scholarly journals Does adjunctive use of metronidazole plus amoxicillin benefit patients receiving non-surgical scaling and root planing for the treatment of generalised aggressive periodontitis?

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Andre W. Van Zyl ◽  
Johan Hartshorne ◽  
Alonso Carrasco-Labra
Keyword(s):  
Test Group ◽  
Randomised Clinical Trial ◽  
Aggressive Periodontitis ◽  
Control Group ◽  
Scaling And Root Planing ◽  
Clinical Attachment Level ◽  
Root Planing ◽  
One Year ◽  
Double Blinded ◽  
Attachment Level

This article describes a double-blinded, placebo-controlled randomised clinical trial thatinvolved 30 eligible subjects experiencing generalised aggressive periodontitis. Subjectswere randomly assigned to either the test group (scaling and root planing + metronidazole[400 mg]) and amoxicillin [500 mg]) or the control group (scaling and root planing withoutthe adjunctive antibiotics combination). Both antibiotics and placebos were administeredthree times per day for 14 days. Participants were examined at baseline, and again six monthsand one year after therapy. Both therapies led to a statistically significant improvementin all clinical parameters as measured after one year. However, subjects who received themetronidazole–amoxicillin combination showed the greatest reduction in mean probingdepth, an improved clinical attachment level and a lower mean number of residual sitesafter one year. The investigators concluded that the non-surgical treatment of generalisedaggressive periodontitis was markedly improved by the adjunctive use of metronidazole andamoxicillin up to one year after treatment.

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