scholarly journals Tétano: Ainda uma Ameaça: Relato de Caso Clínico

2021 ◽  
Vol 27 (1) ◽  
pp. 33-36
Author(s):  
Catarina Carvalho ◽  
Alexandra Albuquerque ◽  
Fátima Campante
Keyword(s):  
Clostridium Tetani

O tétano é uma doença potencialmente fatal, prevenível através da vacinação, causada por neurotoxinas produzidas pelo Clostridium tetani, que cessam a neurotransmissão inibitória. Apresenta uma tríade sintomática: rigidez, espasmos musculares e disfunção autonómica. A abordagem terapêutica é essencialmente sintomática, englobando: limpeza da ferida, sedação, bloqueio neuromuscular, suporte ventilatório e antibioterapia. Apresentamos o caso clínico de uma mulher de 79 anos, com vacina antitetânica desatualizada, admitida em contexto de ferida da face anterior do punho esquerdo, sem profilaxia com imunoglobulina antitetânica. Reavaliada na urgência 5 dias após o evento, com trismo, opistótono, falência respiratória e disautonomia. Procedeu-se a limpeza da ferida, administração de imunoglobulina e antibioterapia, sedação, ventilação mecânica e transferência para uma unidade de cuidados intensivos. Trata-se de um caso sem profilaxia, provavelmente evitável, mostrando a ameaça que o tétano representa, o que deve alertar os profissionais de saúde para a situação imunológica e cumprimento do plano nacional de vacinação.

Ultrastructure of periplasmic bodies in gram-negative bacteria

1990 ◽  
Vol 48 (3) ◽  
pp. 640-641
Author(s):  
Xie Nianming ◽  
Ding Shaoqing ◽  
Wang Luping ◽  
Yuan Zenglin ◽  
Zhan Guolai ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Campylobacter Jejuni ◽  
Proteus Mirabilis ◽  
Shigella Flexneri ◽  
Morphological Description ◽  
Gram Negative Bacteria ◽  
Periplasmic Space ◽  
Clostridium Tetani ◽  
Gram Negative ◽  
Brucella Canis

Perhaps the data about periplasmic enzymes are obtained through biochemical methods but lack of morphological description. We have proved the existence of periplasmic bodies by electron microscope and described their ultrastructures. We hope this report may draw the attention of biochemists and mrophologists to collaborate on researches in periplasmic enzymes or periplasmic bodies with each other.One or more independent bodies may be seen in the periplasmic space between outer and inner membranes of Gram-negative bacteria, which we called periplasmic bodies. The periplasmic bodies have been found in seven species of bacteria at least, including the Pseudomonas aeroginosa. Shigella flexneri, Echerichia coli. Yersinia pestis, Campylobacter jejuni, Proteus mirabilis, Clostridium tetani. Vibrio cholerae and Brucella canis.

scholarly journals DESENVOLVIMENTO DE IMUNÓGENO CONJUGADO DE LIPOPOLISSACARÍDEO DE Pseudomonas Aeruginosa E TOXÓIDE TETÂNICO

2012 ◽  
Vol 17 (2) ◽  
Author(s):  
Bruno Gavinho ◽  
Rosangela Rodrigues Dos Santos ◽  
Luiz Felipe Caron ◽  
Maria Rita Sierakowski ◽  
Lucy Ono
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Clostridium Tetani

O lipopolissacarídeo (LPS) de Pseudomonas aeruginosa foi conjugado ao toxóide tetânico (TT, toxina inativada do Clostridium tetani) utilizando a técnica de aminação redutiva direta, para o desenvolvimento de uma vacina conjugada (LPS-TT). Avaliou-se a resposta imune in vivo após aplicações intraperitoneais do imunógeno LPS-TT em camundongos Swiss, administrando-se 4 aplicações de LPS-TT com intervalos entre as doses de 14 dias. Avaliou-se o título de anticorpos anti-Pseudomonas produzidos pela técnica de soroaglutinação microscópica. Os grupos que foram imunizados com LPS-TT e com LPS+TT (não conjugado quimicamente) apresentaram resposta de anticorpos aglutinantes superior ao controle imunizado apenas com LPS, e a resposta após o reforço vacinal dos animais imunizados com o conjugado LPS-TT foi 567% superior ao dos animais imunizados com LPS.

scholarly journals Infected open depressed skull fracture complicated with tetanus grade I in an unimmunized child: a rare case report with literature review

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Dzulfikar D. L. Hakim ◽  
Ahmad Faried ◽  
Adila Nurhadiya ◽  
Ericko H. Laymena ◽  
Muhammad Z. Arifin ◽  
...  
Keyword(s):  
Rare Case ◽  
Pediatric Population ◽  
Skull Fracture ◽  
Pediatric Intensive Care ◽  
Toxin Production ◽  
Clostridium Tetani ◽  
Anesthetic Care ◽  
Middle Income ◽  
Depressed Skull Fracture ◽  
Low Middle Income Countries

Abstract Background Tetanus is a rare disease caused by Clostridium tetani, which produces tetanolysin and tetanospasmin. In 2018, there were only approximately ten tetanus cases reported in Indonesia. Despite widespread vaccination, especially in low–middle-income countries, tetanus still occurs (mostly in adults) due to the lack of immunization related to religious tenets, cultural belief, or inaccessibility to medical care. In addition, tetanus in the pediatric population shows features which are quite distinct from the adult group. Case presentation We report a case of a 7-year-old girl presented to our institution with a history of falling 10 days prior to admission, with only skin laceration on her forehead. For 1 day prior to admission, the patient looked drowsy and difficult to be awakened, accompanied with stiffness of her jaw; we diagnosed her as an unimmunized child with an open depressed skull fracture of her frontal bone and wound infection complicated with “lockjaw.” Perioperative management of this rare case is reported and discussed. Conclusion The pediatric intensive care of such patients requires halting further toxin production, neutralization of circulating toxin, and control of the clinical manifestation induced by the toxin that has already gained access to the central nervous system. The basic tenets of anesthetic care in such case must be well-managed and planned prior to surgery.

scholarly journals Distribution of Clostridium botulinum and Clostridium tetani in Okinawa Prefecture

1992 ◽  
Vol 66 (12) ◽  
pp. 1639-1644 ◽  
Author(s):  
Toyoko KOBAYASHI ◽  
Kunitomo WATANABE ◽  
Kazue UENO
Keyword(s):  
Clostridium Botulinum ◽  
Clostridium Tetani ◽  
Okinawa Prefecture

scholarly journals Clostridium botulinum in soil on the site of the former Metropolitan (Caledonian) Cattle Market, London

1979 ◽  
Vol 83 (2) ◽  
pp. 237-241 ◽  
Author(s):  
G. R. Smith ◽  
R. A. Milligan
Keyword(s):  
Small Proportion ◽  
Clostridium Botulinum ◽  
Type A ◽  
Soil Samples ◽  
Farm Animals ◽  
Clostridium Tetani ◽  
Faecal Contamination ◽  
The Many ◽  
Soil Surveys ◽  
Cattle Market

summarySixty soil samples were collected from the redeveloped site of the former Metropolitan (Caledonian) Cattle Market, Islington, London. Of these, 15 (25%) contained Clostridium botulinum and no less than four types (B, C, D and E) were demonstrated.Early British soil surveys suggested that only 4–8% of samples contained Cl. botulinum (type A or B). Although there can be no absolute proof, it seems likely that the striking prevalence at the Market site was the result of faecal contamination by a small proportion of the many millions of farm animals brought there from elsewhere.The distribution of Clostridium tetani was uneven, but of 18 soil samples taken from one area of the Market site, 16 (89%) were positive.

Profilaxia do tétano – Protocolo da Unimed Recife

2021 ◽  
pp. 58-60
Author(s):  
Marcelo M. Valença
Keyword(s):  
Clostridium Tetani

O tétano é uma infecção bacteriana grave, não contagiosa, causada pela toxina do bacilo tetânico gram-positivo Clostridium tetani. Os autores estão descrevendo o protocolo de profilaxia do tétano usado na Unimed Recife.

Thermal Death Point: I. Spores of Clostridium Tetani

1931 ◽  
Vol 48 (5) ◽  
pp. 436-456 ◽  
Author(s):  
T. J. Murray ◽  
M. R. Headlee
Keyword(s):  
Clostridium Tetani ◽  
Thermal Death ◽  
Thermal Death Point

scholarly journals Tétanos en un preescolar de 5 años con abandono familiar: Reporte de caso

2019 ◽  
Vol 30 (3) ◽  
Author(s):  
Juan Pablo Guillermo-Durán ◽  
Salvador Gómez-Carro ◽  
Nina Mendez-Dominguez
Keyword(s):  
Foreign Body ◽  
Clinical Findings ◽  
Battered Child Syndrome ◽  
Clostridium Tetani ◽  
Case Presentation ◽  
Battered Child ◽  
Symptomatic Management ◽  
Child Syndrome ◽  
Terapia Intensiva ◽  
Rule Out

Introducción: El tétanos es una enfermedad infecciosa causada por Clostridium tetani, con un cuadro clínico grave y una elevada mortalidad. En Yucatán, la tasa de incidencia es baja (0.09 por 100,000 habitantes), reportándose únicamente dos casos en 2017, por lo que actualmente es una enfermedad de baja sospecha diagnóstica en la región. Caso clínico: Preescolar masculino de 5 años, originario de una comunidad rural de Yucatán y con esquema de inmunización incompleto, quien fue atendido por espasmos musculares generalizados, así como heridas recientes por cuerpo extraño y síndrome del niño maltratado. En la Unidad de Terapia Intensiva, se integró el diagnóstico de tétanos, por lo que recibió manejo etiológico y sintomático, logrando mejoría a su egreso. Discusión: Yucatán es una de las entidades federativas con mayor índice de maltrato infantil. Ante la presencia de dicha problemática social, es importante descartar un esquema de inmunización incompleto, mismos que con la coexistencia de hallazgos clínicos típicos y herida reciente por cuerpo extraño, se debe sospechar tétanos.Background: Tetanus is an infectious disease caused by Clostridium tetani, with severe symptoms and a high mortality rate.  In Yucatan, the incidence rate is low (0.09 per 100,000 population), reporting only two cases in 2017, so it is now a disease of low diagnostic suspicion in the region. Case presentation: A 5-year-old male preschool, from a rural community of Yucatán and with incomplete immunization scheme, who was attended by generalized muscle spasms as well as recent foreign body wounds and battered child syndrome. In the Intensive Care Unit, the diagnosis of tetanus was integrated, for which he received etiological and symptomatic management, achieving improvement at his discharge. Discussion: Yucatan is a state with high child abuse rate of. In the presence of this social problem, it is important to rule out an incomplete immunization scheme, which with the coexistence of typical clinical findings and recent foreign body wound, tetanus should be suspected. 

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