scholarly journals Cloning, Expression, and Purification of the rE2 Protein Human Papillomavirus type 16

Author(s):  
Saucedo Mendiola María Leticia ◽  

Human papillomavirus (HPV) infection is the most common sexually transmitted disease, both in men and women, and the persistence of this infection is the main causative agent of cervical-uterine cancer. HPV 16 protein E2 is important in viral replication and transcription. For this reason, it is of utmost importance to have a reliable method of expression and purification of recombinant E2 (rE2) proteins to carry out experiments focused on the development of drugs against HPV.

2020 ◽  
Vol 5 (4) ◽  
pp. 1-4
Author(s):  
Orkun Ilgen ◽  

Female Sexual Dysfunction (FSD) is a prevalent disorder among women that has negative impacts on life quality. Human Papillomavirus (HPV) infection is the most common sexually-transmitted disease and has a negative emotional effect on women because of causing cervical cancer.


2004 ◽  
Vol 190 (9) ◽  
pp. 1563-1574 ◽  
Author(s):  
Deborah L. Thompson ◽  
John M. Douglas, Jr. ◽  
Mark Foster ◽  
Michael E. Hagensee ◽  
Carolyn DiGuiseppi ◽  
...  

2003 ◽  
Vol 187 (7) ◽  
pp. 1064-1070 ◽  
Author(s):  
Susie B. Baldwin ◽  
Danelle R. Wallace ◽  
Mary R. Papenfuss ◽  
Martha Abrahamsen ◽  
Linda C. Vaught ◽  
...  

2013 ◽  
Vol 142 (8) ◽  
pp. 1579-1589 ◽  
Author(s):  
H. LEE ◽  
D.-H. LEE ◽  
Y.-M. SONG ◽  
K. LEE ◽  
J. SUNG ◽  
...  

SUMMARYBy surveying extensive epidemiological behavioural and sexual risk factors in a Korean twin cohort, risk factors for human papillomavirus (HPV) infection were investigated in South Korea. A total of 912 vaginal specimens were collected from the Healthy Twin Study, consisting of twins and their families. A range of epidemiological, behavioural, and sexual activity characteristics were evaluated using multivariate logistic regression analyses of family and twin relationships, adjusted to elucidate the risk factors for HPV infection. Of the various epidemiological characteristics, the possibility of extramarital affairs [odds ratio (OR) 2·48, 95% confidence interval (CI) 1·02–6·02] significantly increased the prevalence of HPV infection. Our multivariate regression analysis indicated that oral contraceptive use (OR 40·64, 95% CI 0·99–1670·7) and history of sexually transmitted disease (OR 2·56, 95% CI 0·93–7·10) were strongly associated with an increase in HPV infection. On the other hand, more frequent vaginal douching (OR 0·32, 95% CI 0·13–0·77) significantly decreased the prevalence of HPV infection. Our results suggested that HPV infection is associated with both biological and behavioural factors.


2020 ◽  
Author(s):  
Alexandria Richards ◽  
Joanna Stacey

Human papillomavirus, or HPV, is a common sexually transmitted disease, most often acquired during the adolescence or the early 20s. It can be divided into oncogenic and nononcogenic serotypes. It is responsible for genital warts as well as pathologic diseases that can lead to genital cancers and cancers of the oropharyngeal tract in both males and females. The majority of adolescents who acquire HPV infections do not go on to develop cancer. New discoveries about the virus’ persistence and latency direct how we treat adolescents with HPV infections. Recommendations for prevention of HPV include use of the 9-valent vaccine against the most common oncogenic HPV serotypes. Screening should be delayed until the age of 21, with the exception of immunocompromised women. The HPV vaccination is safe and effective, and does not encourage sexual activity among adolescents. Both boys and girls should be vaccinated against HPV at 11 to 12 years of age but may receive the vaccination as early as 9 or as late as 21 (males) or 26 (females) years of age. The vaccine may now also be given in only two doses if the series was started before the age of 15. Follow-up studies in the years after the vaccine’s introduction have shown large decreases in HPV infection rates. This review contains 7 figures, 7 tables and 63 references Key Words: Oncogenic subtype, Oropharyngeal cancer, Infection persistence, Immune tolerance, Cervical dysplasia, Genital warts, 9-valent vaccine, Vaccine safety  


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