Bacterial vaccines and the innate immune system: A journey of rediscovery for the allergist-immunologist and all health care providers

2009 ◽  
Vol 30 (4) ◽  
pp. 3-4 ◽  
Author(s):  
Joseph A. Bellanti ◽  
Russell A. Settipane
2007 ◽  
Vol 5 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Suryaprakash Sambhara ◽  
Robert I Lehrer

2006 ◽  
Vol 41 (3) ◽  
pp. 261-266 ◽  
Author(s):  
M. Angeles Esteban ◽  
Alberto Cuesta ◽  
Alejandro Rodriguez ◽  
Jose Meseguer

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 596
Author(s):  
Nicholas Hanan ◽  
Ronnie L. Doud ◽  
In-Woo Park ◽  
Harlan P. Jones ◽  
Stephen O. Mathew

The innate immune system is important for initial antiviral response. SARS-CoV-2 can result in overactivity or suppression of the innate immune system. A dysregulated immune response is associated with poor outcomes; with patients having significant Neutrophil-to-Lymphocyte ratios (NLR) due to neutrophilia alongside lymphopenia. Elevated interleukin (IL)-6 and IL-8 leads to overactivity and is a prominent feature of severe COVID-19 patients. IL-6 can result in lymphopenia; where COVID-19 patients typically have significantly altered lymphocyte subsets. IL-8 attracts neutrophils; which may play a significant role in lung tissue damage with the formation of neutrophil extracellular traps leading to cytokine storm or acute respiratory distress syndrome. Several factors like pre-existing co-morbidities, genetic risks, viral pathogenicity, and therapeutic efficacy act as important modifiers of SARS-CoV-2 risks for disease through an interplay with innate host inflammatory responses. In this review, we discuss the role of the innate immune system at play with other important modifiers in SARS-CoV-2 infection.


2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Sara Gabrielli ◽  
Claudio Ortolani ◽  
Genny del Zotto ◽  
Francesca Luchetti ◽  
Barbara Canonico ◽  
...  

Although NK cells are considered part of the innate immune system, a series of evidences has demonstrated that they possess characteristics typical of the adaptive immune system. These NK adaptive features, in particular their memory-like functions, are discussed from an ontogenetic and evolutionary point of view.


2018 ◽  
Vol 9 (3) ◽  
pp. 1-17 ◽  
Author(s):  
Liora Sahar ◽  
Rentonia Williams ◽  
Arthi Rao ◽  
Kassandra I. Alcaraz ◽  
Kenneth M. Portier

Labeling geographic areas into rural or urban classes has implications to public policy, distribution of funds and services, as well as analysis and research. Rural-Urban classifications are often limited to dichotomous, county-based comparisons on geographies that can be too large and diverse to effectively assess and resource health care needs and services. Using an existing census tract based classification system, a modified rurality classification layer is proposed and used as a foundation layer in support of research, mission and income programs at a National Non-profit Organization. This system is analyzed by integrating with health services and program data to better understand accessibility and availability of health services, to assess available program offerings, and to evaluate the geographic distribution of health care providers and facilities. The analysis illustrates how identifying intra-rural differences can play a pivotal role in understanding patient needs, assigning adequate resources and can further support public health programs and policy implementation.


Sign in / Sign up

Export Citation Format

Share Document