Analysis of the influence of laparoscopic adjustable gastric banding on BMI, carbohydrate and lipid metabolism in obese patients

Background. Laparoscopic adjustable gastric banding (LAGB) results in significant lasting weight loss and improved metabolism in obese patients. To evaluate whether epigenetic factors could concur to these benefits, we investigated the subcutaneous adipose tissue (SAT) microRNA (miRNA) profile before (T0) and three years (T1) after LAGB in three morbidly obese women. Case Reports. SAT miRNA profiling, evaluated by TaqMan Array, showed four downexpressed (miR-519d, miR-299-5p, miR-212, and miR-671-3p) and two upexpressed (miR-370 and miR-487a) miRNAs at T1 versus T0. Bioinformatics predicted that these miRNAs regulate genes belonging to pathways associated with the cytoskeleton, inflammation, and metabolism. Western blot analysis showed that PPAR-alpha, which is the target gene of miR-519d, increased after LAGB, thereby suggesting an improvement in SAT lipid metabolism. Accordingly, the number and diameter of adipocytes were significantly higher and lower, respectively, at T1 versus T0. Bioinformatics predicted that the decreased levels of miR-212, miR-299-5p, and miR-671-3p at T1 concur in reducing SAT inflammation. Conclusion. We show that the miRNA profile changes after LAGB. This finding, although obtained in only three cases, suggests that this epigenetic mechanism, by regulating the expression of genes involved in inflammation and lipid metabolism, could concur to improve SAT functionality in postoperative obese patients.

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Evaluate the effectiveness of hypoglycemia after laparoscopic bariatric gastric to treat diabete in non-insulin dependent patients due to obesity

Vietnam Journal of Endolaparoscopic Surgery ◽

10.51199/vjsel.2018.3.6 ◽

2018 ◽

Vol 8 (3) ◽

Author(s):

Thanh Phúc Bùi

Keyword(s):

Gastric Banding ◽

Laparoscopic Adjustable Gastric Banding ◽

Adjustable Gastric Banding ◽

Medical Condition ◽

Control Group ◽

Diabetic Patients ◽

Viet Nam ◽

Obese Patients ◽

Insulin Dependent

Tóm tắt Đặt vấn đề: Béo phì là một tình trạng bệnh lý đang gia tăng tại Việt Nam. Phẫu thuật nội soi đặt vòng thắt dạ dày đã được ứng dụng trong điều trị bệnh béo phì. Trong số các người bệnh béo phì có không ít các người bệnh đái đường. Chúng tôi tiến hành thực hiên nghiên cứu này nhằm đánh giá hiệu quả giảm đường huyết sau phẫu thuật nội soi đặt vòng thắt dạ dày điều trị béo phì. Phương pháp nghiên cứu: Nghiên cứu mô tả tiến cứu không có nhóm chứng, theo dõi dọc Kết quả: 22 người bệnh đái tháo đường với BMI trung bình trước mổ là 39.9 được đánh giá đái tháo đường trước và sau mổ với 6 mức độ. Mức độ giảm đường huyết nhiều nhất tại thời điểm 3 tháng sau phẫu thuật. Kết luận: Phẫu thuật nội soi đặt vòng thắt dạ dày không chỉ làm giảm cân nặng mà còn giảm tỷ lệ đái tháo đường ở các người bệnh béo phì. Abstract Introduction: Obesity is a medical condition which has increased in Vietnam. Laparoscopic adjustable gastric banding has been used in the treatment of this disease in recent years. The study aims at evaluating the results of laparoscopic adjustable gastric banding in the treatment of Type 2 Diabetes Mellitus in Viet Duc Hospital. Material and Methods: Prospective descriptive study without a control group, vertical survery methods. Results: This retrospective study includes 22 obese diabetic patients with a preoperative BMI of 39.9± 7.8 kg/m2 who underwent gastric banding. A 6-point scoring system graded the level of anti-diabetic therapy. Downgrading reached its maximum at 3 months after operation. Conclusion: Laparoscopic adjustable gastric banding is a highly effective method to lose weight as well as decrease diabete rate in obese patients. Keyword: Diabetes, obesity, laparoscopic adjustable gastric banding.

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Ultrasound Measurement of Visceral and Subcutaneous Fat in Morbidly Obese Patients Before and after Laparoscopic Adjustable Gastric Banding: Comparison with Computerized Tomography and with Anthropometric Measurements

Obesity Surgery ◽

10.1381/096089202321019620 ◽

2002 ◽

Vol 12 (5) ◽

pp. 648-651 ◽

Cited By ~ 57

Author(s):

A.E. Pontiroli ◽

P. Pizzocri ◽

M. Giacomelli ◽

M. Marchi ◽

P. Vedani ◽

...

Keyword(s):

Gastric Banding ◽

Computerized Tomography ◽

Laparoscopic Adjustable Gastric Banding ◽

Adjustable Gastric Banding ◽

Subcutaneous Fat ◽

Anthropometric Measurements ◽

Ultrasound Measurement ◽

Morbidly Obese ◽

Obese Patients ◽

Before And After

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100 obese patients after laparoscopic adjustable gastric banding – the influence on BMI, gherlin and insulin concentration, parameters of lipid balance and co-morbidities

Advances in Medical Sciences ◽

10.2478/v10039-012-0008-8 ◽

2012 ◽

Vol 57 (1) ◽

pp. 58-64 ◽

Cited By ~ 11

Author(s):

HR Hady ◽

J Dadan ◽

P Gołaszewski

Keyword(s):

Gastric Banding ◽

Laparoscopic Adjustable Gastric Banding ◽

Adjustable Gastric Banding ◽

Insulin Concentration ◽

Obese Patients ◽

Lipid Balance

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Risk of Atrial Fibrillation and Stroke After Bariatric Surgery in Patients With Morbid Obesity With or Without Obstructive Sleep Apnea

Stroke ◽

10.1161/strokeaha.120.031920 ◽

2021 ◽

Author(s):

Ahmed Dalmar ◽

Maharaj Singh ◽

Zoe Heis ◽

Tabitha L. Cumpian ◽

Cheryl Ceretto ◽

...

Keyword(s):

Atrial Fibrillation ◽

Body Mass Index ◽

Weight Loss ◽

Gastric Banding ◽

Laparoscopic Adjustable Gastric Banding ◽

Adjustable Gastric Banding ◽

Morbidly Obese ◽

Obese Patients ◽

Obstructive Sleep ◽

New Onset

Background and Purpose: Weight loss in morbidly obese patients reduces atrial fibrillation (AF); however, it is unknown whether similar benefits are maintained in patients with obstructive sleep apnea (OSA). We sought to determine whether incident AF and stroke rates are affected by OSA after weight loss and to identify predictors of AF and stroke. Methods: Differences in laparoscopic adjustable gastric banding–induced weight loss on incident AF and stroke events in those with and without OSA in the entire and in propensity-matched cohorts were determined longitudinally, and independent predictors of AF and stroke were identified. Results: Of 827 morbidly obese patients who underwent laparoscopic adjustable gastric banding (mean age, 44±11 years; mean body mass index, 49±8 kg/m 2 ), incident AF was documented in 4.96% and stroke in 5.44% of patients during a mean 6.0±3.2-year follow-up. Despite a similar reduction in body weight (19.6% and 21% in 3 years), new-onset AF was significantly higher in patients with OSA than without OSA in the entire (1.7% versus 0.5% per year; P <0.001) and propensity-matched cohorts. Incident stroke was higher in the OSA than in the non-OSA group (2.10% versus 0.47% per year; P <0.001), but only 20% of patients with stroke had documented AF. On multivariate analysis, OSA (hazard ratio, 2.88 [95% CI, 1.45–5.73]), age, and hypertension were independent predictors of new-onset AF, and OSA (hazard ratio, 5.84 [95% CI, 3.02–11.30]), depression, and body mass index were for stroke events. Conclusions: In morbidly obese patients who underwent laparoscopic adjustable gastric banding, despite similar weight loss, patients with OSA had a higher incidence of AF and stroke than patients without OSA. Both non-AF and AF-related factors were involved in increasing stroke risk. Further investigation is warranted into whether OSA treatment helps reduce AF or stroke events in this population.

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