Evaluate the effectiveness of hypoglycemia after laparoscopic bariatric gastric to treat diabete in non-insulin dependent patients due to obesity

2018 ◽  
Vol 8 (3) ◽  
Author(s):  
Thanh Phúc Bùi
Keyword(s):  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Adjustable Gastric Banding ◽  
Medical Condition ◽  
Control Group ◽  
Diabetic Patients ◽  
Viet Nam ◽  
Obese Patients ◽  
Insulin Dependent

Tóm tắt Đặt vấn đề: Béo phì là một tình trạng bệnh lý đang gia tăng tại Việt Nam. Phẫu thuật nội soi đặt vòng thắt dạ dày đã được ứng dụng trong điều trị bệnh béo phì. Trong số các người bệnh béo phì có không ít các người bệnh đái đường. Chúng tôi tiến hành thực hiên nghiên cứu này nhằm đánh giá hiệu quả giảm đường huyết sau phẫu thuật nội soi đặt vòng thắt dạ dày điều trị béo phì. Phương pháp nghiên cứu: Nghiên cứu mô tả tiến cứu không có nhóm chứng, theo dõi dọc Kết quả: 22 người bệnh đái tháo đường với BMI trung bình trước mổ là 39.9 được đánh giá đái tháo đường trước và sau mổ với 6 mức độ. Mức độ giảm đường huyết nhiều nhất tại thời điểm 3 tháng sau phẫu thuật. Kết luận: Phẫu thuật nội soi đặt vòng thắt dạ dày không chỉ làm giảm cân nặng mà còn giảm tỷ lệ đái tháo đường ở các người bệnh béo phì. Abstract Introduction: Obesity is a medical condition which has increased in Vietnam. Laparoscopic adjustable gastric banding has been used in the treatment of this disease in recent years. The study aims at evaluating the results of laparoscopic adjustable gastric banding in the treatment of Type 2 Diabetes Mellitus in Viet Duc Hospital. Material and Methods: Prospective descriptive study without a control group, vertical survery methods. Results: This retrospective study includes 22 obese diabetic patients with a preoperative BMI of 39.9± 7.8 kg/m2 who underwent gastric banding. A 6-point scoring system graded the level of anti-diabetic therapy. Downgrading reached its maximum at 3 months after operation. Conclusion: Laparoscopic adjustable gastric banding is a highly effective method to lose weight as well as decrease diabete rate in obese patients. Keyword: Diabetes, obesity, laparoscopic adjustable gastric banding.

scholarly journals Comparison of Changes in Blood Glucose, Insulin Resistance Indices, and Adipokine Levels in Diabetic and Nondiabetic Subjects With Morbid Obesity After Laparoscopic Adjustable Gastric Banding

Medicina ◽  
2013 ◽  
Vol 49 (1) ◽  
pp. 2
Author(s):  
Vaidotas Urbanavičius ◽  
Tomas Abalikšta ◽  
Gintautas Brimas ◽  
Agnė Abraitienė ◽  
Laima Gogelienė ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Adjustable Gastric Banding ◽  
Morbidly Obese

Objective. The aim of the study was to evaluate blood glucose, insulin resistance indices, and adipokine (leptin and adiponectin) levels in morbidly obese individuals with and without type 2 diabetes mellitus and to compare the changes in these parameters 1 year after laparoscopic adjustable gastric banding surgery. Material and Methods. In total, 103 patients (37 subjects with and 66 subjects without type 2 diabetes mellitus) were studied preoperatively and again 1 year after laparoscopic adjustable gastric banding. Results. One year after laparoscopic adjustable gastric banding, the leptin concentrations decreased significantly in both treatment groups, while the adiponectin levels increased significantly in the nondiabetic patients (11.19 μg/mL [SD 7.20] vs. 15.58 μg/mL [SD 7.8], P=0.003) and tended to increase in the group of the patients with type 2 diabetes mellitus (8.98 μg/mL [SD 6.80] vs. 13.01 μg/mL [SD 12.14], P>0.05). A considerable decrease in the insulin resistance indices was noted in the patients with type 2 diabetes mellitus 1 year after the intervention, and it was followed by a partial or complete remission of type 2 diabetes mellitus in 23 (85.19%) of the 27 investigated diabetic patients. The postoperative insulin resistance indices in the patients with type 2 diabetes mellitus became similar to the values in the nondiabetic subjects. Conclusions. Weight loss after laparoscopic adjustable gastric banding is associated with a significant increase in adiponectin secretion in nondiabetic morbidly obese patients and with improvement in adiponectin secretion in type 2 diabetes individuals. In subjects with type 2 diabetes, this surgical intervention results in a significant reduction in blood glucose and insulin resistance.

scholarly journals Risk of Atrial Fibrillation and Stroke After Bariatric Surgery in Patients With Morbid Obesity With or Without Obstructive Sleep Apnea

Stroke ◽  
2021 ◽  
Author(s):  
Ahmed Dalmar ◽  
Maharaj Singh ◽  
Zoe Heis ◽  
Tabitha L. Cumpian ◽  
Cheryl Ceretto ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Weight Loss ◽  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Adjustable Gastric Banding ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
New Onset

Background and Purpose: Weight loss in morbidly obese patients reduces atrial fibrillation (AF); however, it is unknown whether similar benefits are maintained in patients with obstructive sleep apnea (OSA). We sought to determine whether incident AF and stroke rates are affected by OSA after weight loss and to identify predictors of AF and stroke. Methods: Differences in laparoscopic adjustable gastric banding–induced weight loss on incident AF and stroke events in those with and without OSA in the entire and in propensity-matched cohorts were determined longitudinally, and independent predictors of AF and stroke were identified. Results: Of 827 morbidly obese patients who underwent laparoscopic adjustable gastric banding (mean age, 44±11 years; mean body mass index, 49±8 kg/m 2 ), incident AF was documented in 4.96% and stroke in 5.44% of patients during a mean 6.0±3.2-year follow-up. Despite a similar reduction in body weight (19.6% and 21% in 3 years), new-onset AF was significantly higher in patients with OSA than without OSA in the entire (1.7% versus 0.5% per year; P <0.001) and propensity-matched cohorts. Incident stroke was higher in the OSA than in the non-OSA group (2.10% versus 0.47% per year; P <0.001), but only 20% of patients with stroke had documented AF. On multivariate analysis, OSA (hazard ratio, 2.88 [95% CI, 1.45–5.73]), age, and hypertension were independent predictors of new-onset AF, and OSA (hazard ratio, 5.84 [95% CI, 3.02–11.30]), depression, and body mass index were for stroke events. Conclusions: In morbidly obese patients who underwent laparoscopic adjustable gastric banding, despite similar weight loss, patients with OSA had a higher incidence of AF and stroke than patients without OSA. Both non-AF and AF-related factors were involved in increasing stroke risk. Further investigation is warranted into whether OSA treatment helps reduce AF or stroke events in this population.

scholarly journals Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Carmela Nardelli ◽  
Laura Iaffaldano ◽  
Vincenzo Pilone ◽  
Giuseppe Labruna ◽  
Maddalena Ferrigno ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Subcutaneous Adipose Tissue ◽  
Adjustable Gastric Banding ◽  
Epigenetic Mechanism ◽  
Mirna Profile ◽  
Obese Patients ◽  
Subcutaneous Adipose

Background. Laparoscopic adjustable gastric banding (LAGB) results in significant lasting weight loss and improved metabolism in obese patients. To evaluate whether epigenetic factors could concur to these benefits, we investigated the subcutaneous adipose tissue (SAT) microRNA (miRNA) profile before (T0) and three years (T1) after LAGB in three morbidly obese women. Case Reports. SAT miRNA profiling, evaluated by TaqMan Array, showed four downexpressed (miR-519d, miR-299-5p, miR-212, and miR-671-3p) and two upexpressed (miR-370 and miR-487a) miRNAs at T1 versus T0. Bioinformatics predicted that these miRNAs regulate genes belonging to pathways associated with the cytoskeleton, inflammation, and metabolism. Western blot analysis showed that PPAR-alpha, which is the target gene of miR-519d, increased after LAGB, thereby suggesting an improvement in SAT lipid metabolism. Accordingly, the number and diameter of adipocytes were significantly higher and lower, respectively, at T1 versus T0. Bioinformatics predicted that the decreased levels of miR-212, miR-299-5p, and miR-671-3p at T1 concur in reducing SAT inflammation. Conclusion. We show that the miRNA profile changes after LAGB. This finding, although obtained in only three cases, suggests that this epigenetic mechanism, by regulating the expression of genes involved in inflammation and lipid metabolism, could concur to improve SAT functionality in postoperative obese patients.

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