scholarly journals Structure, Absolute Configuration and Biological Evaluation of a New Labdane Diterpenoid from Jatropha podagrica

2020 ◽  
Vol 14 (5) ◽  
pp. 355-360
Author(s):  
Dongbo Zhang ◽  
Jingao Yu ◽  
Zhen Zhang ◽  
Yanni Liang ◽  
Zhishu Tang ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Biological Evaluation ◽  
Labdane Diterpenoid

scholarly journals De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa

2019 ◽  
Vol 10 (27) ◽  
pp. 6635-6641 ◽  
Author(s):  
Jian Zhang ◽  
Tianhu Zhao ◽  
Rongwen Yang ◽  
Ittipon Siridechakorn ◽  
Sanshan Wang ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Total Synthesis ◽  
Natural Product ◽  
Absolute Configuration ◽  
De Novo ◽  
Biological Evaluation ◽  
De Novo Synthesis ◽  
Structural Assignment ◽  
The Absolute

The first total synthesis and isolation of pseudopaline was reported, which allows determination and confirmation of the absolute configuration of the natural product.

scholarly journals Biological evaluation and determination of the absolute configuration of chloromonilicin, a strong antimicrobial metabolite isolated from Alternaria sonchi

2015 ◽  
Vol 69 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Alessio Cimmino ◽  
Gennaro Pescitelli ◽  
Alexander Berestetskiy ◽  
Anna Dalinova ◽  
Denis Krivorotov ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Biological Evaluation ◽  
Antimicrobial Metabolite ◽  
The Absolute

scholarly journals Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 158 ◽  
Author(s):  
Yan-Jiao Yin ◽  
Dan-Ling Huang ◽  
Bin Qiu ◽  
Dan Cai ◽  
Jiao-Jiao Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Absolute Configuration ◽  
Human Cancer ◽  
Biological Evaluation ◽  
Chemical Methods ◽  
Chiral Phase ◽  
Human Cancer Cells ◽  
Ic50 Values

Five new meroterpenoids, zizhines P-S and U (1−4,7), together with two known meroterpenoids (5 and 6) were isolated from Ganoderma sinensis. Their structures including absolute configurations were assigned by using spectroscopic, computational, and chemical methods. Racemics zizhines P and Q were purified by HPLC on chiral phase. Biological evaluation found that 4, 5 and 6 are cytotoxic toward human cancer cells (A549, BGC-823, Kyse30) with IC50 values in the range of 63.43–80.83 μM towards A549, 59.2 ± 2.73 μM and 64.25 ± 0.37 μM towards BGC-823, 76.28 ± 1.93 μM and 85.42 ± 2.82 μM towards Kyse30.

scholarly journals Improved synthesis, resolution, absolute configuration determination and biological evaluation of HLM006474 enantiomers

2019 ◽  
Vol 29 (3) ◽  
pp. 380-382 ◽  
Author(s):  
Miyanou Rosales-Hurtado ◽  
Alexandre Lebeau ◽  
Cyril Bourouh ◽  
Gerardo Cebrian-Torrejon ◽  
Muriel Albalat ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Biological Evaluation

Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation

2012 ◽  
Vol 75 (6) ◽  
pp. 1025-1029 ◽  
Author(s):  
Yong-Ming Yan ◽  
Gui-Sheng Wu ◽  
Xiao-Ping Dong ◽  
Lan Shen ◽  
Yan Li ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Biological Evaluation

scholarly journals Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Ashraf H. Abadi ◽  
Jochen Lehmann ◽  
Gary A. Piazza ◽  
Mohammad Abdel-Halim ◽  
Mohamed S. M. Ali
Keyword(s):  
Amino Acid ◽  
Molecular Modeling ◽  
Absolute Configuration ◽  
Biological Evaluation ◽  
Economic Advantage ◽  
Pde5 Inhibitors ◽  
Pde5 Inhibition ◽  
Chiral Carbon ◽  
Hydantoin Derivatives ◽  
Phosphodiesterase 5

Two series of fused tetrahydro-β-carboline hydantoin and tetrahydro-β-carboline thiohydantoin derivatives with a pendant 2,4-dimethoxyphenyl at position 5 were synthesized, and chiral carbons at positions 5 and 11a swing from R,R to R,S, S,R, and S,S. The prepared analogues were evaluated for their capacity to inhibit phosphodiesterase 5 (PDE5) isozyme. The R absolute configuration of C-5 in the β-carboline hydantoin derivatives was found to be essential for the PDE5 inhibition. Chiral carbon derived from amino acid even if of the S configuration (L-tryptophan) may lead to equiactive or more active isomers than those derived from amino acid with the R configuration (D-tryptophan). This expands the horizon from which efficient PDE5 inhibitors can be derived and may offer an economic advantage. The thiohydantoin derivatives were less active than their hydantoin congeners.

scholarly journals Stereospecificity of Retinol Saturase:  Absolute Configuration, Synthesis, and Biological Evaluation of Dihydroretinoids

2008 ◽  
Vol 130 (4) ◽  
pp. 1154-1155 ◽  
Author(s):  
Alexander R. Moise ◽  
Marta Domínguez ◽  
Susana Alvarez ◽  
Rosana Alvarez ◽  
Michael Schupp ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Biological Evaluation ◽  
Configuration Synthesis ◽  
Synthesis And Biological Evaluation
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