scholarly journals Demographic, clinico-pathological features and management pattern of primary bone tumors in a tertiary care hospital of South India

2021 ◽  
Vol 8 (1) ◽  
pp. 60
Author(s):  
Subbiah Shanmugam ◽  
Sujay Susikar ◽  
Bharanidharan T. ◽  
Arun Victor Jebasingh
Keyword(s):  
Bone Tumor ◽  
Bone Tumors ◽  
Tertiary Care ◽  
Tumor Location ◽  
Care Hospital ◽  
Pathological Features ◽  
Primary Bone Tumor ◽  
Primary Bone Tumors ◽  
True Incidence ◽  
Primary Bone

<p><strong>Background</strong>: Primary bone tumors are very rare tumors. The true incidence of bone tumors is not well established and is under reported due to rarity and lack of accurate registries. Hence it is essential to study about the demographic, clinico-pathological features and the pattern of surgical management of bone tumors. The aim of this study is to analyze the demographic and clinico-pathological features of primary bone tumors that were managed by surgery.</p><p><strong>Methods</strong>: A retrospective analysis of all patients with primary bone tumor who were treated by surgery from 2012 to 2019 was done. The age, sex distribution, histopathology, location of the tumor and surgical procedure done were analyzed.</p><p><strong>Results</strong>: Among 103 patients analyzed, 66 (64%) were men and 37 (36%) were women. Primary bone tumors most commonly presented in 11 to 20 years of age with 35 (33.9%) patients occurring in this age group. Osteosarcoma was the most common primary bone tumor and it occurred in 49 (47.6%) patients, out of which 34 (69.3%) patients were below 20 years of age. Giant cell tumor was the most common benign bone tumor and it occurred in 22 patients, out of which nine (40.9%) patients were of age 21 to 30 years. Distal femur was the most common site with 39 (37.9%) patients. The limb preservation rate for malignant appendicular bone tumors was 69.0%.</p><p><strong>Conclusions</strong>: The diagnosis of bone tumor depends not only on histopathological features but also needs correlation with age, clinical features, tumor location and radiological features for confirmation of diagnosis.</p>

scholarly journals Tracheal chondrosarcoma and surgical management

2018 ◽  
Vol 27 (1) ◽  
pp. 52-54 ◽  
Author(s):  
Fazal Wahab Khan ◽  
Ibrahim Zahid ◽  
Sarosh Moeen ◽  
Sulaiman Bashir Hasan
Keyword(s):  
Surgical Management ◽  
Bone Tumor ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Obstructive Apnea ◽  
Primary Bone Tumor ◽  
Cartilage Cells ◽  
Primary Bone

Chondrosarcoma is a cancer of cartilage cells, and despite being a common primary bone tumor, tracheal chondrosarcoma is rare with only 18 cases reported in the literature prior to mid-2016. A 60-year-old gentleman presented with progressively increasing cough, severe stridor, and production of phlegm for approximately 2 years. On admission to our tertiary care hospital, he developed complete obstructive apnea within an hour, and was intubated. A tracheal biopsy was performed, followed by resection. Histopathology confirmed chondrosarcoma of the trachea. The patient tolerated the procedure very well and is currently symptom-free on follow-up, with no signs of recurrence.

scholarly journals A retrospective analysis of computed tomography guided biopsy in the diagnosis of primary bone tumors

2017 ◽  
Vol 3 (3) ◽  
pp. 569
Author(s):  
Kuriakku Puthur Dominic ◽  
Davis Dijoe ◽  
Jacob Toms
Keyword(s):  
Computed Tomography ◽  
Bone Tumors ◽  
Diagnostic Efficiency ◽  
Ct Guided ◽  
Primary Bone Tumor ◽  
Primary Bone Tumors ◽  
Guided Biopsy ◽  
Ct Guided Biopsy ◽  
Significant Step ◽  
Primary Bone

<p><strong>Background:</strong> Primary bone tumors account for a small yet significant number in the total incidence of tumors. Computed tomography (CT) guided percutaneous core biopsy is a novel yet significant step in the approach towards the diagnosis of bone tumors and is increasingly performed by orthopaedic oncologists around the world. This study is aimed to evaluate the diagnostic accuracy of CT guided biopsy in the diagnosis of primary bone tumors. <strong></strong></p><p><strong>Methods:</strong> Patients who underwent CT guided biopsy and subsequent excision for primary bone tumors from January 2008 to July 2015 were analysed. CT guided biopsy results were compared with post-operative histopathological reports to evaluate its sensitivity and specificity.</p><p><strong>Results:</strong> A total of 161 patients were included in the retrospective study. Among them, 147 were true positives, 7 were false negatives, 6 were true negatives and one was false positive. The sensitivity of CT guided biopsy in the diagnosis of primary bone tumor was 95.4 % with specificity of 85.7% with a diagnostic efficiency of 90.5%. The complication rate was 4.3%.</p><p><strong>Conclusions:</strong> CT guided biopsy is a safe, simple and effective procedure to rule out and rule in the diagnosis of primary bone tumors.</p>

scholarly journals Primary Bone Tumor of the Spine—An Evolving Field: What a General Spine Surgeon Should Know

2019 ◽  
Vol 9 (1_suppl) ◽  
pp. 108S-116S ◽  
Author(s):  
Raphaële Charest-Morin ◽  
Charles G. Fisher ◽  
Arjun Sahgal ◽  
Stefano Boriani ◽  
Ziya L. Gokaslan ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Bone Tumors ◽  
Treatment Algorithm ◽  
Significant Risk ◽  
Primary Bone Tumor ◽  
Primary Bone Tumors ◽  
Quaternary Centers ◽  
Treatment Paradigm ◽  
Primary Bone ◽  
Spine Surgeon

Study Design: A narrative review of the literature. Objective: This article reviews the general principles of treatment and investigation for primary bone tumors of the spine. Furthermore, it explores the emerging alternatives. Methods: A review was performed using Medline, Embase, and Cochrane databases. Results: Primary bone tumors of the spine are rare entities that general spine surgeons may encounter only a few times in their career. The treatment algorithm of these complex tumors is filled with nuances and is evolving constantly. For these reasons, patients should be referred to experienced tertiary or quaternary centers who can offer a comprehensive multidisciplinary approach. For most malignant spinal bone tumors, surgery remains the cornerstone of treatment. Respecting oncologic principles has been associated with improved survival and decreased local recurrence in multiple settings. However, even in experienced centers, these surgeries carry a significant risk of adverse events and possible long-term neurologic impairment. The associated morbidity of these procedures and the challenges of local recurrence have encouraged professionals caring for these patients to explore alternatives or adjuncts to surgical treatment. Conclusions: Over the past few years, several advances have occurred in medical oncology, radiation oncology and interventional radiology, changing the treatment paradigm for some tumors. Other advances still need to be refined before being applied in a clinical setting.

scholarly journals Primary aggressive chondroblastoma of the tibia

2020 ◽  
Vol 27 (2) ◽  
pp. E202021
Author(s):  
Reda Badaoui ◽  
Amine Elmaqrout ◽  
Mohamed Boussaidan ◽  
Jalal Mekaoui ◽  
Jalal Boukhriss ◽  
...  
Keyword(s):  
Young Adults ◽  
Soft Tissue ◽  
Malignant Transformation ◽  
Bone Tumor ◽  
Bone Tumors ◽  
Benign Tumor ◽  
Primary Bone Tumor ◽  
Proven Case ◽  
Primary Bone ◽  
Ossification Centers

Chondroblastoma is a primary bone tumor in children, adolescents and young adults, which accounts for 1% of all bone tumors. Epiphyseal or epiphysometaphyseal localization, this lesion usually develops from secondary ossification centers close to the knee, shoulder and hip. Although chondroblastoma is a nonaggressive benign tumor, it can very rarely show a locally aggressive character or a malignant transformation or even metastases. We describe a histologically proven case of an aggressive, primary chondroblastoma of the tibia invading soft tissue in a 22-year-old girl.

Malignant Osteoid Matrix Bone Tumors

2019 ◽  
pp. 251-258
Author(s):  
Abhijit Datir
Keyword(s):  
Bone Tumor ◽  
Bone Tumors ◽  
Age Groups ◽  
Bone Destruction ◽  
Tissue Mass ◽  
Primary Bone Tumor ◽  
Radiologic Findings ◽  
Conventional Osteosarcoma ◽  
Skip Lesions ◽  
Primary Bone

Chapter 53 discusses malignant osteoid matrix bone tumors and focuses on several types of osteosarcoma, ranging from the most common, conventional osteosarcoma, to secondary osteosarcomas, such as Paget and postradiation sarcomas. Osteosarcoma is the most common primary bone tumor in children and adolescents, and second most frequent primary malignant bone tumor if all age groups are considered. A short discussion on typical radiologic findings with classic examples of various types of osteosarcoma is included. Conventional radiographs show an aggressive lesion with permeative bone destruction, extraosseous soft tissue mass and cortical disruption with periosteal reaction. MRI is useful for assessing tumor extent and skip lesions. Treatment includes surgery and chemotherapy.

Perioperative adverse events following surgery for primary bone tumors of the spine and en bloc resection for metastases

2020 ◽  
Vol 32 (1) ◽  
pp. 98-105
Author(s):  
Raphaële Charest-Morin ◽  
Alana M. Flexman ◽  
Shreya Srinivas ◽  
Charles G. Fisher ◽  
John T. Street ◽  
...  
Keyword(s):  
Adverse Events ◽  
Bone Tumors ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
En Bloc ◽  
Primary Bone Tumors ◽  
True Incidence ◽  
Icu Stay ◽  
Primary Bone ◽  
Surgical Duration

OBJECTIVESurgical treatment of primary bone tumors of the spine and en bloc resection for isolated metastases are complex and challenging. Operative care is fraught with complications, though the true incidence and predictors of adverse events (AEs), length of stay (LOS), and mortality in this population remain poorly understood. The primary objective of this study was to describe the incidence and predictors of perioperative AEs in these patients. Secondary objectives included the determination of the incidence and predictors of admission to the intensive care unit (ICU), unanticipated reoperation during the same admission, hospital LOS, and mortality.METHODSIn this retrospective analysis of prospectively collected data, the authors included consecutive patients at a single quaternary care referral center (January 1, 2009, to September 30, 2018) who underwent either surgery for a primary bone tumor of the spine or an en bloc resection for an isolated spinal metastasis. Information on perioperative AEs, demographic data, primary tumor histology, neurological status, surgical variables, pathological margins, Enneking appropriateness, LOS, ICU stay, reoperation during the same admission period, and in-hospital mortality was collected prospectively in the institutional database. The modified frailty score was extracted retrospectively.RESULTSOne hundred thirteen patients met the inclusion criteria: 98 with primary bone tumors and 15 with isolated metastases. The cohort was 59% male, and the mean age was 49 years (SD 19 years). Overall, 79% of the patients experienced at least 1 AE. The median number of AEs per patient was 2 (IQR 0–4 AEs), and the median LOS was 16 days (IQR 9–32 days). No in-hospital deaths occurred in the cohort. Thirty-two patients (28%) required an ICU stay and 19% underwent an unanticipated second surgery during their admission. A longer surgical duration was associated with a higher likelihood of AEs (OR 1.21/hour, 95% CI 1.06–1.37, p = 0.005), longer ICU stay (OR 1.35/hour, 95% CI 1 1.20–1.52, p < 0.001), and reoperation (OR 1.001/hour, 95% CI 1.0003–1.003, p = 0.012). Longer hospital LOS was independently predicted by older age, female sex, upper cervical and sacral location of the tumor, surgical duration, preoperative neurological deficit, presence of AEs, and higher modified frailty index score.CONCLUSIONSSurgeries for primary bone tumors and en bloc resection for metastatic tumors are associated with a high incidence of perioperative AEs. Surgical duration predicts complications, reoperation, LOS, and ICU stay.

scholarly journals Profile of Musculoskeletal Tumor in Saiful Anwar General Hospital Malang from January 2011 until December 2018

2020 ◽  
Vol 16 (2) ◽  
pp. 81
Author(s):  
Istan Irmansyah Irsan ◽  
Satria Pandu Persada Isma ◽  
Abdul Aziz ◽  
Muhammad Hilman Bimadi ◽  
I Gusti Ngurah Arga Aldrian Oktafandi
Keyword(s):  
Soft Tissue ◽  
General Hospital ◽  
Bone Tumor ◽  
Bone Tumors ◽  
Malignant Tumors ◽  
Soft Tissue Tumors ◽  
Musculoskeletal Tumor ◽  
Primary Bone Tumors ◽  
Musculoskeletal Tumors ◽  
Primary Bone

Abstract: Musculoskeletal tumors are relatively rare, with 0.2%-0.5% of all malignant tumors in all ages. The geographic distribution of musculoskeletal tumors varies significantly around the world. This study aims to describe the musculoskeletal tumor profile in Saiful Anwar General Hospital. All data were obtained from the department of orthopaedic and traumatology database, Saiful Anwar general hospital. Thus, patients who were diagnosed with either bone tumor or soft tissue tumor between January 2011 to December 2018 were selected for the present study. The clinical-pathological conference (CPC) was carried out to ensure the validity of all the registered data. A total of 577 patients with tumors from January 2011 to December 2018 was obtained. Out of all the cases, 439 (76%) cases are bone tumors, and the remaining 138 (24%) cases are soft tissue tumors. The most frequent locations of the musculoskeletal tumors are the long bones of the thigh and lower leg. This study shows an increasing trend in musculoskeletal tumors incidence, despite decreasing numbers in several years. This result goes along with a rising trend in malignancy cases with a higher amount compared to the benign one. Moreover, MBD and osteosarcoma were found to be the most common tumor and primary bone tumors, respectively. However, the fact that there is some data loss in the study limited the study for a more accurate result.   Keywords: Musculoskeletal tumor; Bone tumor; Osteosarcoma; Malang; East Java

scholarly journals A retrospective analysis of bone tumors and tumor like lesions: a hospital based study of 76 cases

2017 ◽  
Vol 5 (11) ◽  
pp. 4915
Author(s):  
Manoj Kumar Deka ◽  
Anuradha Talukdar
Keyword(s):  
Bone Tumors ◽  
Primary Bone Tumor ◽  
Primary Bone Tumors ◽  
Skeletal Site ◽  
Primary Bone ◽  
To Come ◽  
Histologic Types ◽  
Conclusive Diagnosis ◽  
Tumor Like Lesions ◽  
Age Range

Background: Globally Bone tumors constitute 0.5% of the total World Cancer Incidence. In addition to benign and malignant bone tumors there are a number of nonneoplastic lesions that present in a manner similar to neoplastic conditions. Relevant demographic features such as age, sex and skeletal site are important to come to a conclusive diagnosis. The present study aims to show the prevalence and demography of bone tumors and tumor like lesions.Methods: A total of 76 cases of Bone Tumors and Tumor like Lesions were studied. They were reviewed and analyzed for age, gender, site of tumor and histologic types. Classification was done according to WHO histologic Classification of Bone Tumors.Results: There were 49 cases of primary bone tumors and tumor Like lesions with a median age of 22 years and 27 cases of metastatic bone tumors with a median age of 56 years. Males are more commonly affected. Osteosarcomas and Chondrosarcomas are the most common primary malignant Bone Tumors.Conclusions: Metastatic bone tumors constitute the highest number of bone tumors occurring at an older age group. Maximum numbers of bone tumors are found in the age range 11-20 years and all are primary bone tumor and tumor like lesions.

Scintigraphy with 99m Tc-Phosphonate and 67Gallium in Patients Suspected of Primary Bone Tumors

1982 ◽  
Vol 21 (04) ◽  
pp. 136-139 ◽  
Author(s):  
C.-J. Edeling
Keyword(s):  
Soft Tissue ◽  
Bone Scintigraphy ◽  
Primary Tumor ◽  
Bone Tumors ◽  
Whole Body ◽  
Skeletal Metastases ◽  
Malignant Bone Tumors ◽  
67Ga Scintigraphy ◽  
Primary Bone Tumors ◽  
Primary Bone

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

Sign in / Sign up

Export Citation Format

Share Document