Matrix metalloproteinases: structure, functions and genetic polymorphism

2017 ◽  
pp. 14-23
Author(s):  
А.С. Шадрина ◽  
И.В. Терешкина ◽  
Я.З. Плиева ◽  
Д.Н. Кушлинский ◽  
Д.О. Уткин ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Matrix Metalloproteinases ◽  
Active Center ◽  
Human Body ◽  
Enzymatic Catalysis ◽  
Structure Functions ◽  
Zinc Ion ◽  
Etiological Factors ◽  
Mmp Genes

Матриксные металлопротеиназы (ММП) - ферменты класса гидролаз, осуществляющие ферментативный катализ с помощью связанного в активном центре иона цинка. Функции ММП разнообразны, и нарушение баланса их активности может быть одним из этиологических факторов различных заболеваний. В данном обзоре рассмотрена классификация ММП человека, особенности их структуры и регуляции, а также роль в физиологических и патологических процессах в организме человека. Приведен перечень наиболее изученных на настоящий момент полиморфных вариантов генов MMП, описаны их функциональные эффекты и представлены результаты ассоциативных исследований. Matrix metalloproteinases (MMPs) are enzymes of the hydrolase class that carry out enzymatic catalysis with the help of a zinc ion bound in the active center. MMP functions are diverse, and a disturbance in the balance of their activity may be one of the etiological factors of various diseases. In this review, the classification of human MMP, the features of their structure and regulation, as well as the role in physiological and pathological processes in the human body are considered. A list of the most studied polymorphic versions of MMP genes has been given, their functional effects have been described, and the results of associative studies have been presented.

scholarly journals Ecologically informed microbial biomarkers and accurate classification of mixed and unmixed samples in an extensive cross-study of human body sites

Microbiome ◽  
2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Janko Tackmann ◽  
Natasha Arora ◽  
Thomas Sebastian Benedikt Schmidt ◽  
João Frederico Matias Rodrigues ◽  
Christian von Mering
Keyword(s):  
Human Body ◽  
Microbial Biomarkers

scholarly journals Abnormal Hypermethylation of CpG Dinucleotides in Promoter Regions of Matrix Metalloproteinases Genes in Breast Cancer and its Relation to Epigenomic Subtypes and HER2 Overexpression

Biomedicines ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 116
Author(s):  
Olga A. Simonova ◽  
Ekaterina B. Kuznetsova ◽  
Alexander S. Tanas ◽  
Viktoria V. Rudenko ◽  
Elena V. Poddubskaya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinases ◽  
Cpg Island ◽  
Breast Cancer Subtype ◽  
Ectopic Expression ◽  
Her2 Overexpression ◽  
Restriction Enzyme Digestion ◽  
Promoter Regions ◽  
Cpg Dinucleotides ◽  
Mmp Genes

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) substantially contribute to the regulation of intercellular interactions and thereby play a role in maintaining the tissue structure and function. We examined methylation of a subset of 5’-cytosine-phosphate-guanine-3’ (CpG) dinucleotides in promoter regions of the MMP2, MMP11, MMP14, MMP15, MMP16, MMP17, MMP21, MMP23B, MMP24, MMP25, MMP28, TIMP1, TIMP2, TIMP3, and TIMP4 genes by methylation-sensitive restriction enzyme digestion PCR. In our collection of 183 breast cancer samples, abnormal hypermethylation was observed for CpGs in MMP2, MMP23B, MMP24, MMP25, and MMP28 promoter regions. The non-methylated status of the examined CpGs in promoter regions of MMP2, MMP23B, MMP24, MMP25, and MMP28 in tumors was associated with low HER2 expression, while the group of samples with abnormal hypermethylation of at least two of these MMP genes was significantly enriched with HER2-positive tumors. Abnormal methylation of MMP24 and MMP25 was significantly associated with a CpG island hypermethylated breast cancer subtype discovered by genome-wide DNA bisulfite sequencing. Our results indicate that abnormal hypermethylation of at least several MMP genes promoters is a secondary event not directly functional in breast cancer (BC) pathogenesis. We suggest that it is elevated and/or ectopic expression, rather than methylation-driven silencing, that might link MMPs to tumorigenesis.

Quantum Chemistry Study on the Interaction of the Exogenous Ligands and the Catalytic Zinc Ion in Matrix Metalloproteinases

2002 ◽  
Vol 106 (17) ◽  
pp. 4552-4559 ◽  
Author(s):  
Feng Cheng ◽  
Ruihao Zhang ◽  
Xiaomin Luo ◽  
Jianhua Shen ◽  
Xin Li ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Quantum Chemistry ◽  
Zinc Ion ◽  
Exogenous Ligands ◽  
Catalytic Zinc

scholarly journals Genetic polymorphism of matrix metalloproteinases in breast cancer

Neoplasma ◽  
2012 ◽  
Vol 59 (03) ◽  
pp. 237-247 ◽  
Author(s):  
E. WIECZOREK ◽  
E. RESZKA ◽  
J. GROMADZINSKA ◽  
W. WASOWICZ
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphism ◽  
Matrix Metalloproteinases

Reaction mechanism of matrix metalloproteinases with a catalytically active zinc ion studied by the QM(DFTB)/MM simulations

2016 ◽  
Vol 26 (3) ◽  
pp. 209-211 ◽  
Author(s):  
Tatiana Vasilevskaya ◽  
Maria G. Khrenova ◽  
Alexander V. Nemukhin ◽  
Walter Thiel
Keyword(s):  
Reaction Mechanism ◽  
Matrix Metalloproteinases ◽  
Zinc Ion ◽  
Catalytically Active

scholarly journals IMPORTANCE OF RELATIONSHIP BETWEEN MOVEMENT RHYTHM AND RESPIRATION IN PHYSICAL EDUCATION AND IN TOP-LEVEL SPORT

2013 ◽  
Vol 20 (3) ◽  
pp. 167-174 ◽  
Author(s):  
Włodzimierz Starosta
Keyword(s):  
Human Body ◽  
Educational System ◽  
Mental Hygiene ◽  
Ability To Work ◽  
Health Maintenance ◽  
National Cultures ◽  
Respiration Rhythm ◽  
The Subject ◽  
The Brain

Abstract The existence of a human body is conditioned by: food, sleep, respiration. Without air man can live approximately 4 minutes. A longer break in access of oxygen to the brain results in irreversible changes of its functioning. Majority of adultscannot breathe economically and rhythmically. If respiration has such importance for the normal life of a man it shouldconstitute a significant part of educational system. Only in few national cultures, including Asia (e.g. in Japan andChina) the ability to breathe was made into an art. There, this art is subject to special care throughout many years of life of a person and is an essential component of mental hygiene. Respiration has particular importance while practicing physical exercise. The correct combination of respiration rhythm and movement is a prerequisite to remain healthy and to keep the ability to work, as well as to achieve high results in sport. Scarce information about this important issue could be found in some handbooks concerning health maintenance, but they were not found in the theory of: movement teaching, recreation, anthropokinesiology. It was a little number of papers publish about this very important problem [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16]. The issue of rational respiration was the subject of particular interest of scientists several years ago, but recently it has become only marginal. Consequently, the aim of this paper was to: 1. Study the literature connected with respiration and movement rhythm. 2. To define which phase of respiration: expiration or inspiration is more important in different sport exercises. 3. Elaboration a classification of kind respiration phase and different sports. 4. Methods for creating the art of rational respiration. 5. Relation of rational respiration rhythm to endurance.

scholarly journals Modern Classification of the Properties of Papillary Patterns of Human Hands and Feet for the Solution of Identification and Non-Identification Problems in Forensic Expert Activities

2021 ◽  
Vol 18 (4) ◽  
pp. 445-459
Author(s):  
V. I. Balko
Keyword(s):  
Body Fat ◽  
Human Body ◽  
Identification Problems ◽  
Basic Properties ◽  
Modern Classification ◽  
Definition Of ◽  
Hands And Feet ◽  
First Time ◽  
Papillary Pattern

The relevance and novelty of the topic of the article is connected with the fact that for the first time the improved classification of the properties of human papillary patterns and their displays and the dynamic trend of expanding the legal base of fingerprint registration in the world are considered. The goal is to systematize the properties of human papillary patterns and their representations. General scientific and special methods were used. The analysis of the literature and the author's practice allow us to identify and consider the following properties of papillary patterns and their mappings, which were divided into three groups for cognitive purposes: their own properties, the properties of mappings, and the properties of the fat-rich substance of the human papillary pattern and its trace. For the first time, the properties of the poly-fat substance of the human papillary pattern and its trace are presented, which is important in view of the trend in the development of complex fingerprint examination. For the first time, the first and second groups are conditionally divided into four subgroups: for solving identification, diagnostic, classification and situational problems. For the first time, the third group is further conditionally divided into four subgroups: according to the interaction of the human body fat with the carrier object; according to the isolation of the human body fat trace; according to the dynamics of the preservation and contrast of the display of the fat-free substance of the human papillary pattern. On the other hand, the properties of papillary patterns themselves are divided into basic properties and properties for solving identification and non-identification problems, respectively. The author's definition of the following concepts is presented: "basic properties of human papillary patterns" and "properties of human papillary patterns", "basic properties of human papillary patterns mappings" and "properties of human papillary patterns mappings", "basic properties of human papillary matter" and "properties of human papillary matter", "basic properties of human papillary matter" and" properties of human papillary matter". This provides an opportunity for specialists and teachers to improve their cognitive and practical activities, and for those responsible and competent for the organization of examinations to consider creating a center for comprehensive fingerprint examination.

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