LONG-TERM IMPACT OF REPEATED IMMUNIZATION WITH INACTIVATED INFLUENZA VACCINE ON RESPIRATORY ILLNESS IN HIGH-RISK CHILDREN

High Risk Children (HRC) are those with an increased risk of abnormal development due to any factor affecting neurological growth. Those factors have been the focus of most studies in this area. However, little is known about their long-term consequences over the course of child development. Objectives: the goal was to study the cognitive, emotional and academic outcomes of 7-year-old children diagnosed as HRC at birth. Method: We compared 14 HRC and 20 healthy children using the WISC-IV, BASC and Brunet-Lezine tests. Results: HRC showed cognitive, emotional and academic deficits compared with healthy children. However, Brunet-Lezine scores obtained over the course of development (6, 12, 18 and 24 months) were not predictive of the children's' current psychological status. Conclusions: long-term follow-up with HRC should be maintained until 7 years of age, at which point an appropriate treatment should be implemented.

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Long-Term Impact of a Community Pharmacist Intervention on Cholesterol Levels in Patients at High Risk for Cardiovascular Events: Extended Follow-up of the Second Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP-plus)

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy ◽

10.1592/phco.25.1.110.55619 ◽

2005 ◽

Vol 25 (1) ◽

pp. 110-115 ◽

Cited By ~ 22

Author(s):

Carol Yamada ◽

Jeffrey A. Johnson ◽

Patrick Robertson ◽

Glen Pearson ◽

Ross T. Tsuyuki

Keyword(s):

Cardiovascular Risk ◽

High Risk ◽

Community Pharmacist ◽

Cardiovascular Events ◽

Pharmacist Intervention ◽

Cholesterol Levels ◽

Long Term Impact

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Short-changed during the bacillus Calmette–Guérin shortages?

Journal of Clinical Urology ◽

10.1177/2051415820941780 ◽

2020 ◽

pp. 205141582094178

Author(s):

Kenneth R MacKenzie ◽

Sidney D Parker ◽

Dawn Watson ◽

Joanne Cresswell

Keyword(s):

High Risk ◽

Treatment Strategies ◽

Disease Free Survival ◽

Disease Recurrence ◽

Bacillus Calmette Guerin ◽

Level Of Evidence ◽

Significant Difference ◽

Muscle Invasive ◽

Long Term Impact

Objective: Intravesical bacillus Calmette–Guérin (BCG) is the first-line treatment of choice for high-risk non-muscle-invasive bladder cancer (NMIBC). Our aim was to evaluate the long-term impact of BCG shortages on oncological outcomes. Methods: All patients undertaking an initial course of intravesical BCG for intermediate or high risk NMIBC at a single UK cancer centre between August 2012 and August 2014 were evaluated. Compliance was defined as completing 12 doses of BCG within the first year following diagnosis. Results: Due to BCG shortages, 25/114 (22%) patients were compliant with planned maintenance treatment. Compared to the compliant cohort, the non-compliant due to BCG shortages cohort had a higher rate of disease recurrence (35.3% vs. 24%), required more additional intravesical treatments (14.7% vs. 12%) and had a higher rate of radical cystectomy (11.8% vs. 4%). Disease-free survival was superior in the compliant cohort at two years (88% vs. 79.5%) and at 4.5 years (72% vs. 56.1%). There was no statistically significant difference, likely due to the sample size. Conclusions: The consequences of undertreatment due to BCG shortages can impact long-term cancer outcomes. Increased vigilance, robust long-term surveillance and alternative treatment strategies are required for NMIBC patients affected by shortages in BCG supplies. Level of evidence: Level 2b

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