Relevance of PTGS1 and PTGS2 gene polymorphisms to gastric cancer risk and phenotype in Caucasians.

The association between vascular endothelial growth factor (VEGF) +936 C/T gene polymorphisms and gastric cancer risk is still controversial and ambiguous. The objective of our study was to investigate this association. The Medline and Embase databases were searched by two investigators. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to test the association between VEGF +936 C/T polymorphisms and gastric cancer risk. Our meta-analysis comprised seven case-control studies, which included 1,893 gastric cancer cases and 2,245 controls. The combined results showed that there was no relationship between VEGF +936 C/T gene polymorphisms and gastric cancer risk (cc: OR 0.97, 95% CI 0.85, 1.11; CT: OR 1.01, 95% CI 0.88, 1.16; TT: OR 1.10, 95% CI 0.79, 1.55). Subgroup analysis by ethnicity and stage, location, and Lauren classification of gastric cancer did not change the results. This meta-analysis suggests that there is no association between VEGF +936 C/T polymorphisms and gastric cancer risk. Further studies should pay attention to other potentially functional SNPs.

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Effects of IL-10 and IL-6 Gene Polymorphisms and Atomic-bomb Radiation Exposure on Gastric Cancer Risk

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(08)71852-4 ◽

2008 ◽

Vol 6 (9) ◽

pp. 190

Author(s):

T. Hayashi ◽

Y. Morishita ◽

H. Nagamura ◽

M. Maki ◽

K. Imai ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Risk ◽

Radiation Exposure ◽

Gene Polymorphisms ◽

Atomic Bomb ◽

Gastric Cancer Risk

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Interleukin-1 Gene Polymorphisms and Gastric Cancer Risk in a High-Risk Italian Population

The American Journal of Gastroenterology ◽

10.1111/j.1572-0241.2005.50084.x ◽

2005 ◽

Vol 100 (9) ◽

pp. 1941-1948 ◽

Cited By ~ 49

Author(s):

D. Palli ◽

C. Saieva ◽

I. Luzzi ◽

G. Masala ◽

S. Topa ◽

...

Keyword(s):

Gastric Cancer ◽

High Risk ◽

Cancer Risk ◽

Gene Polymorphisms ◽

Interleukin 1 ◽

Italian Population ◽

Gastric Cancer Risk

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Gastric cancer risk predisposition and prognostic significance of vascular endothelial growth factor (VEGF) gene polymorphisms in an Omani population

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.4568 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 4568-4568

Author(s):

M. S. Al-Moundhri ◽

M. Al-Nabhani ◽

I. Burney ◽

A. Rizvi ◽

A. Al-Farsi ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Cancer Risk ◽

Gene Polymorphisms ◽

Prognostic Significance ◽

Disease Stage ◽

Gastric Cancer Risk ◽

Vegf Gene ◽

Risk Predisposition ◽

Vegf Polymorphisms

4568 Background: VEGF plays a central role in the angiogenesis, tumor growth and metastasis. VEGF gene polymorphisms at various loci and gastric cancer (GC) risk predisposition and their prognostic significance were studied previously with controversial results Methods: We analyzed three VEGF polymorphisms (+405 G>C, -460T>C, and +936C>T) by extraction of genomic DNA from peripheral blood of 130 GC patients and 130 control subjects followed by VEGF genotyping using PCR-RFLP analysis and the determination of the polymorphisms GC risk predisposition and their prognostic significance Results: There was no significant association between the VEGF polymorphisms and gastric cancer risk. There was a significant correlation between +405 C/C genotype and poor tumor differentiation (p=0.007) and lymph node metastasis (p=0.03) and 460T/T genotype and poor differentiation (p=0.03) with statistical trend for lymph node involvement (p=0.05). VEGF gene polymorphisms had no significant effect on survival, but VEGF +405 G/G genotype had lower survival with hazard ratio 1.6 [95% CI, 0.9–2.9] compared to VEGF +405 CC/GC combined genotype (p=0.04). Multivariate analysis showed that disease stage at diagnosis, and +405 G/G genotype were independent variables of adverse prognostic significance. There were no associations between the common six haplotypes identified and GC risk predisposition and survival. Conclusions: The current study suggests that VEGF polymorphisms in GC patients may have predictive and prognostic significance. No significant financial relationships to disclose.

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