Individually Tailored Prophylaxis with C1-INH Concentrate in four Pediatric Patients with Hereditary Angioedema (HAE) – Real Life Data

Author(s):  
Inmaculada  Martinez Saguer
Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 416
Author(s):  
Nadia Marascio ◽  
Maria Mazzitelli ◽  
Grazia Pavia ◽  
Aida Giancotti ◽  
Giorgio Settimo Barreca ◽  
...  

Direct-acting antiviral drugs to cure infections with Hepatitis C virus (HCV) achieve a sustained virological response (SVR) in more than 90% of adult patients. At present, clinical trials are ongoing and real-life data are still limited in children. Herein, we report two cases of pediatric patients treated with fixed-dose combination of sofosbuvir/ledipasvir, already approved to treat HCV4 genotype. Both young girls achieved SVR even though HCV4 isolates carried L28M and M31L NS5A resistance-associated substitutions (RASs). Therefore, possible effects of these RASs merit further study, especially in children.


2020 ◽  
Author(s):  
Aline Risson Belinovski ◽  
Polliany Dorini Pelegrina ◽  
Alberto Cardoso Martins Lima ◽  
Gisele Loth ◽  
Adriana Mello Rodrigues ◽  
...  

2014 ◽  
Vol 25 (4) ◽  
pp. 233-238 ◽  
Author(s):  
Martin Peper ◽  
Simone N. Loeffler

Current ambulatory technologies are highly relevant for neuropsychological assessment and treatment as they provide a gateway to real life data. Ambulatory assessment of cognitive complaints, skills and emotional states in natural contexts provides information that has a greater ecological validity than traditional assessment approaches. This issue presents an overview of current technological and methodological innovations, opportunities, problems and limitations of these methods designed for the context-sensitive measurement of cognitive, emotional and behavioral function. The usefulness of selected ambulatory approaches is demonstrated and their relevance for an ecologically valid neuropsychology is highlighted.


Author(s):  
Eleni Pantazi ◽  
Alexios Travlos ◽  
Evaggelia Vogiatzi ◽  
Ifigenia Kostoglou-Athanassiou

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