In the brain, mRNA translation regulation plays a major role during different processes, including development, learning and memory, and synaptic plasticity. While the initiation phase of translation is considered to be the rate-limiting step, regulation of the elongation phase via the eukaryotic elongation factor 2 kinase (eEF2K) pathway is also pivotal for memory and synaptic plasticity consolidation. Understanding the molecular mechanisms underpinning memory and synaptic plasticity formation is invaluable for understanding basic mechanisms underlying cognitive function and the identification of effective targets for cognitive disorders. This chapter discusses the molecular function of the eEF2/eEF2K pathway in memory consolidation, synaptic plasticity, and neurological diseases. In addition, it describes possible new genetic tools that would be useful in determining the neuronal function of eEF2K in health and disease conditions.
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases
