Translation regulation in neurodegenerative diseases: what we know about the eukaryotic elongation factor-2 kinase (eEF2K) in Alzheimer and Parkinson’s disease.

2018 ◽  
Author(s):  
Asad Jan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Elongation Factor ◽  
Translation Regulation ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor

The Role of the Eukaryotic Elongation Factor 2 (eEF2) Pathway in Neuronal Function

2020 ◽  
Author(s):  
Elham Taha ◽  
Kobi Rosenblum
Keyword(s):  
Synaptic Plasticity ◽  
Molecular Mechanisms ◽  
Neurological Diseases ◽  
Elongation Factor ◽  
Mrna Translation ◽  
Translation Regulation ◽  
Neuronal Function ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor

In the brain, mRNA translation regulation plays a major role during different processes, including development, learning and memory, and synaptic plasticity. While the initiation phase of translation is considered to be the rate-limiting step, regulation of the elongation phase via the eukaryotic elongation factor 2 kinase (eEF2K) pathway is also pivotal for memory and synaptic plasticity consolidation. Understanding the molecular mechanisms underpinning memory and synaptic plasticity formation is invaluable for understanding basic mechanisms underlying cognitive function and the identification of effective targets for cognitive disorders. This chapter discusses the molecular function of the eEF2/eEF2K pathway in memory consolidation, synaptic plasticity, and neurological diseases. In addition, it describes possible new genetic tools that would be useful in determining the neuronal function of eEF2K in health and disease conditions.

Flavonoids from Deguelia duckeana inhibit the eukaryotic elongation factor 2 (eEF2) in SK-N-SH neuronal cells

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
LMC Cursino ◽  
NM Lima ◽  
R Murillo ◽  
I Merfort ◽  
M Humar ◽  
...  
Keyword(s):  
Neuronal Cells ◽  
Elongation Factor ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor

Effect of oxidative stress on in vivo ADP-ribosylation of eukaryotic elongation factor 2

2005 ◽  
Vol 37 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Muhammet Bektaş ◽  
Handan Akçakaya ◽  
Aysin Aroymak ◽  
Rüstem Nurten ◽  
Engin Bermek
Keyword(s):  
Oxidative Stress ◽  
Elongation Factor ◽  
Adp Ribosylation ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor

scholarly journals Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2

2019 ◽  
Vol 74 (1) ◽  
pp. 88-100.e9 ◽  
Author(s):  
Leonie Mönkemeyer ◽  
Courtney L. Klaips ◽  
David Balchin ◽  
Roman Körner ◽  
F. Ulrich Hartl ◽  
...  
Keyword(s):  
Elongation Factor ◽  
Chaperone Function ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor

Eukaryotic Elongation Factor 2 (eEF2) is a Potential Biomarker of Prostate Cancer

2017 ◽  
Vol 24 (4) ◽  
pp. 885-890 ◽  
Author(s):  
Xuefeng Zhang ◽  
Linkun Hu ◽  
Mingzhan Du ◽  
Xuedong Wei ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Elongation Factor ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor ◽  
Potential Biomarker
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