Cigarette smoking and vascular dementia in rats: relationships with oxidative stress

2018 ◽  
Author(s):  
Tijen Utkan ◽  
Tugce Demirtas Sahin
Keyword(s):  
Oxidative Stress ◽  
Cigarette Smoking ◽  
Vascular Dementia

Cigarette smoking and vascular dementia in rats: Relationships with oxidative stress

2019 ◽  
Vol 29 ◽  
pp. S155-S156
Author(s):  
T. Utkan ◽  
Y. Yazir ◽  
G. Gacar ◽  
S.S. Gocmez ◽  
T. Demirtaş Şahin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cigarette Smoking ◽  
Vascular Dementia

A single serving of blueberry (V. corymbosum) modulates peripheral arterial dysfunction induced by acute cigarette smoking in young volunteers: a randomized-controlled trial

2014 ◽  
Vol 5 (12) ◽  
pp. 3107-3116 ◽  
Author(s):  
Cristian Del Bo’ ◽  
Marisa Porrini ◽  
Daniela Fracassetti ◽  
Jonica Campolo ◽  
Dorothy Klimis-Zacas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Randomized Controlled Trial ◽  
Endothelial Dysfunction ◽  
Cigarette Smoking ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Peripheral Arterial

Cigarette smoking causes oxidative stress, hypertension and endothelial dysfunction.

(2R,3S)-Pinobanksin-3-cinnamate improves cognition and reduces oxidative stress in rats with vascular dementia

2015 ◽  
Vol 69 (3) ◽  
pp. 358-365 ◽  
Author(s):  
Hong Liu ◽  
Min Zhao ◽  
Shen Yang ◽  
Dian-Rong Gong ◽  
De-Zhe Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vascular Dementia

Abstract 352: Real-time Intravital Optical Imaging Reflects the Dynamic Changes of Oxidative Stress Induced by Cigarette Smoking in Vasculatures

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Ji Bak Kim ◽  
Jiheun Ryu ◽  
Joon Woo Song ◽  
Dong Joo Oh ◽  
DaeGab Gweon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cigarette Smoking ◽  
Optical Imaging ◽  
Real Time ◽  
Treated Group ◽  
Fluorescence Signal ◽  
Ros Production ◽  
Protective Effects ◽  
Dynamic Changes

Background: Reactive oxygen species (ROS) play a central role in cigarette smoking-induced atherogenesis. The present study aims to assess the smoking-induced acute oxidative stress within vasculatures, and evaluates whether the resveratrol, a natural polyphenol antioxidant, can counteract this ROS production, using a customized, high resolution intravital optical imaging in real-time. Methods and Results: 20-week-old male C57BL/6 mice were divided into four groups according to the preceding administration of resveratrol (R) (25mg/kg via gavage, for 7 days) and exposure to cigarette smoke (CS). To in vivo assess acute oxidative stress in blood vessels, dihydroethidium, which forms a red fluorescence (ethidium, excitation/emission: 520nm/610nm) upon reaction with ROS, was injected intraperitoneally. During CS exposure, temporal changes of fluorescence signals from the mouse cremaster muscle including vasculatures were assessed by intravital optical imaging for 15 minutes. Fluorescence signals were much more pronounced in CS exposed mice than controls (p<0.001). Resveratrol p.o. significantly reduced the CS-induced ROS signals compared to the non-treated group (fluorescence signal to noise ratio, SNR, 2.51±0.09 vs. 12.52±2.116, p=0.0002) (Figure A). Without CS exposure, fluorescence signals in targeted vasculatures were very low showing no difference between groups (SNR, 1.65±0.19 vs. 1.53±0.07, p=0.80) (Figure A). Lipid peroxidation was increased in CS group and significantly attenuated in resveratrol-treated mice (Figure B). Fluorescence microscopy and immunostainings corroborated the in vivo findings. Conclusions: The intravital optical imaging was able to in vivo estimate the dynamic changes of ROS production by CS exposure. Our data demonstrated that even a brief exposure to CS increased oxidative stress in vasculatures promptly, and the resveratrol exerts protective effects against the CS-induced acute oxidative stress.

Anethum graveolens mitigates vascular dementia: Role of oxidative stress and eNOS

2018 ◽  
Vol 07 ◽  
Author(s):  
Supaporn Muchimapura ◽  
Jintanaporn Wattanathorn ◽  
Wipawee Thukham-mee
Keyword(s):  
Oxidative Stress ◽  
Vascular Dementia ◽  
Anethum Graveolens

scholarly journals Real-World Evidence of Differences in Biomarkers of Exposure to Select Harmful and Potentially Harmful Constituents and Biomarkers of Potential Harm Between Adult E-Vapor Users and Adult Cigarette Smokers

2019 ◽  
Vol 22 (7) ◽  
pp. 1114-1122 ◽  
Author(s):  
Douglas Oliveri ◽  
Qiwei Liang ◽  
Mohamadi Sarkar
Keyword(s):  
Oxidative Stress ◽  
Carbon Monoxide ◽  
Cigarette Smoking ◽  
Real World ◽  
Cigarette Smokers ◽  
Potential Harm ◽  
Biomarkers Of Exposure ◽  
Real World Evidence ◽  
Actual Use ◽  
Lower Health

Abstract Introduction Real-world evidence regarding likely long-term health effects of e-vapor products (EVP) under actual use conditions relative to cigarette smoking is not well studied. Methods In this cross-sectional, observational study, biomarkers of exposure (BOE) to select harmful and potentially harmful constituents and biomarkers of potential harm (BOPH) relevant to smoking-related diseases were measured in exclusive adult EVP users (AEVP, n = 144) and exclusive adult cigarette smokers (AS, n = 73). AEVP used their own brand of EVP for 6+ months following 10+ years of cigarette smoking and AS smoked own brand of cigarettes for 10+ years. Subject recruitment and informed consent were obtained online and urine/blood samples were collected at local clinical laboratories, representing a new paradigm for collecting real-world evidence. Results The levels of total NNAL (NNK metabolite), 3-hydroxypropyl mercapturic acid (acrolein metabolite), and carboxyhemoglobin (carbon monoxide measure) were 46% to 86% lower in AEVP compared with AS (p ≤ .0001) as was nicotine equivalents (nicotine and its five metabolites; 36%, p &lt; .01). The levels of some BOPH were significantly lower in AEVP compared with AS for 11-dehydrothromboxane-B2 (29%, p = .04; platelet activation), 8-epi-prostaglandin F2α (23%, p = .02; oxidative stress) and soluble intercellular adhesion molecule-1 (16%, p = .02; endothelial function). Conclusions This study demonstrates the feasibility of a new approach for collecting real-world evidence. Substantially lower levels of BOEs (NNK, nicotine, acrolein, carbon monoxide) and favorable differences in BOPHs (platelet activation, oxidative stress, endothelial function) suggest EVP users may have lower health risks than cigarette smokers. Implications Cigarette smoking causes serious diseases. Switching from a combustible tobacco product to a noncombustible product is a potential harm reduction pathway for adult smokers unable or unwilling to quit. Real-world evidence regarding the relative risk of EVP use compared with cigarettes is not well established. This study provides data specific to BOE to tobacco smoke constituents and biomarkers of potential harm collected under actual use conditions in a real-world setting. The totality of evidence suggests that exclusive EVP use may present lower health risk compared with smoking cigarettes.

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