scholarly journals DIAGNOSTIC PREFERENCE OF GADOPICLENOL-ENHANCED MRI OF CENTRAL NERVOUS SYSTEM (CNS): A POST-HOC ANALYSIS BY MAGNETIC FIELD STRENGTH AND LESION TYPE

2020 ◽  
Author(s):  
Ibrahim Bedioune
Keyword(s):  
Magnetic Field ◽  
Central Nervous System ◽  
Nervous System ◽  
Field Strength ◽  
Magnetic Field Strength ◽  
Post Hoc Analysis ◽  
Enhanced Mri ◽  
Lesion Type ◽  
Post Hoc

scholarly journals The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies

2021 ◽  
Author(s):  
Darren M. Brenner ◽  
Neal E. Slatkin ◽  
Nancy Stambler ◽  
Robert J. Israel ◽  
Paul H. Coluzzi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Metastases ◽  
Cancer Patients ◽  
Opioid Withdrawal ◽  
Double Blind ◽  
Post Hoc Analysis ◽  
Pain Scores ◽  
Opioid Receptor Antagonists ◽  
Post Hoc

Abstract Purpose Peripherally acting μ-opioid receptor antagonists such as methylnaltrexone (MNTX, Relistor®) are indicated for the treatment of opioid-induced constipation (OIC). The structural properties unique to MNTX restrict it from traversing the blood-brain barrier (BBB); however, the BBB may become more permeable in patients with brain metastases. We investigated whether the presence of brain metastases in cancer patients compromises the central effects of opioids among patients receiving MNTX for OIC. Methods This post hoc analysis of pooled data from 3 randomized, placebo-controlled trials included cancer patients with OIC who received MNTX or placebo. Endpoints included changes from baseline in pain scores, rescue-free laxation (RFL) within 4 or 24 h of the first dose, and treatment-emergent adverse events (TEAEs), including those potentially related to opioid withdrawal symptoms. Results Among 356 cancer patients in the pooled population, 47 (MNTX n = 27; placebo n = 20) had brain metastases and 309 (MNTX n = 172; placebo n = 137) did not have brain metastases. No significant differences in current pain, worst pain, or change in pain scores from baseline were observed between patients treated with MNTX or placebo. Among patients with brain metastases, a significantly greater proportion of patients who received MNTX versus placebo achieved an RFL within 4 h after the first dose (70.4% vs 15.0%, respectively, p = 0.0002). TEAEs were similar between treatment groups and were generally gastrointestinal in nature and not related to opioid withdrawal. Conclusion Focal disruptions of the BBB caused by brain metastases did not appear to alter central nervous system penetrance of MNTX.

On the Configuration of the Magnetic Field of β CrB

1976 ◽  
Vol 32 ◽  
pp. 613-622
Author(s):  
I.A. Aslanov ◽  
Yu.S. Rustamov
Keyword(s):  
Magnetic Field ◽  
Field Strength ◽  
Radial Velocity ◽  
Magnetic Field Strength ◽  
Complex Shape ◽  
Rotation Period ◽  
Field Variation ◽  
Magnetic Field Variation ◽  
Secular Variations ◽  
The Magnetic Field

SummaryMeasurements of the radial velocities and magnetic field strength of β CrB were carried out. It is shown that there is a variability with the rotation period different for various elements. The curve of the magnetic field variation measured from lines of 5 different elements: FeI, CrI, CrII, TiII, ScII and CaI has a complex shape specific for each element. This may be due to the presence of magnetic spots on the stellar surface. A comparison with the radial velocity curves suggests the presence of a least 4 spots of Ti and Cr coinciding with magnetic spots. A change of the magnetic field with optical depth is shown. The curve of the Heffvariation with the rotation period is given. A possibility of secular variations of the magnetic field is shown.

2D analysis of magnetic field strength in GO SiFe steel sheets

1998 ◽  
Vol 08 (PR2) ◽  
pp. Pr2-579-Pr2-582 ◽  
Author(s):  
S. Tumanski ◽  
M. Stabrowski
Keyword(s):  
Magnetic Field ◽  
Field Strength ◽  
Magnetic Field Strength ◽  
Steel Sheets

MAGNETIC FIELD, PRESSURE AND TEMPERATURE DEPENDENT OPTICAL PROPERTIES IN A GaAs 9.0 P 1.0 QUANTUM DOT

2014 ◽  
Vol 6 (2) ◽  
pp. 1178-1190
Author(s):  
A. JOHN PETER ◽  
Ada Vinolin
Keyword(s):  
Magnetic Field ◽  
Optical Properties ◽  
Quantum Dot ◽  
Field Strength ◽  
Magnetic Field Strength ◽  
Photon Energy ◽  
Nonlinear Optical ◽  
Binding Energies ◽  
Nonlinear Optical Properties ◽  
Optical Rectification

Simultaneous effects of magnetic field, pressure and temperature on the exciton binding energies are found in a 9.0 1.0 6.0 4.0 GaAs P / GaAs P quantum dot. Numerical calculations are carried out taking into consideration of spatial confinement effect. The cylindrical system is taken in the present problem with the strain effects. The electronic properties and the optical properties are found with the combined effects of magnetic field strength, hydrostatic pressure and temperature values. The exciton binding energies and the nonlinear optical properties are carried out taking into consideration of geometrical confinement and the external perturbations.Compact density approach is employed to obtain the nonlinear optical properties. The optical rectification coefficient is obtained with the photon energy in the presence of pressure, temperature and external magnetic field strength. Pressure and temperature dependence on nonlinear optical susceptibilities of generation of second and third order harmonics as a function of incident photon energy are brought out in the influence of magnetic field strength. The result shows that the electronic and nonlinear optical properties are significantly modified by the applications of external perturbations in a 9.0 1.0 6.0 4.0 GaAs P / GaAs P quantum dot.

Magnetic field strength dependence of chemical shift artifacts

1988 ◽  
Vol 12 (2) ◽  
pp. 89-96 ◽  
Author(s):  
R. Lufkin ◽  
M. Anselmo ◽  
J. Crues ◽  
W. Smoker ◽  
W. Hanafee
Keyword(s):  
Magnetic Field ◽  
Chemical Shift ◽  
Field Strength ◽  
Magnetic Field Strength ◽  
Strength Dependence

scholarly journals Enhancement for magnetic field strength of a magnetohydrodynamic thruster consisting of permanent magnets

AIP Advances ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 015008
Author(s):  
Yan-Hom Li ◽  
Cing-Hui Zeng ◽  
Yen-Ju Chen
Keyword(s):  
Magnetic Field ◽  
Field Strength ◽  
Magnetic Field Strength ◽  
Permanent Magnets

scholarly journals Validation of a scaling law for the coronal magnetic field strength and loop length of solar and stellar flares

2016 ◽  
Vol 69 (1) ◽  
pp. 7 ◽  
Author(s):  
Kosuke Namekata ◽  
Takahito Sakaue ◽  
Kyoko Watanabe ◽  
Ayumi Asai ◽  
Kazunari Shibata
Keyword(s):  
Magnetic Field ◽  
Field Strength ◽  
Magnetic Field Strength ◽  
Scaling Law ◽  
Coronal Magnetic Field ◽  
Loop Length ◽  
Stellar Flares
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