Recombinant Allergens – Production Methods and Use in Molecular Diagnosis and Allergen Immunotherapy

Abstract: The only causal treatment for the allergic diseases is the allergen immunotherapy. Besides oral and injection forms, an epicutaneous form is known as well. During the immunization process the use of an adjuvant material is advisable besides the allergen. That adjuvant material can be (besides of the aluminium hydroxid and tyrosine) a bacterial toxin, too. In idealistic circumstances we can substitute the native allergen with its recombinant variant, which could keep its immunogenicity but had lost the allergenicity. In the future the recommended therapy could be the safe, painless, epicutaneous hyposensitization, with recombinant allergens, with bacterial toxin as adjuvants. Orv Hetil. 2017; 158(23): 895–899.

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Molecular diagnosis for allergen immunotherapy

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2018.12.1021 ◽

2019 ◽

Vol 143 (3) ◽

pp. 831-843 ◽

Cited By ~ 20

Author(s):

Paolo Maria Matricardi ◽

Stephanie Dramburg ◽

Ekaterina Potapova ◽

Chrysanthi Skevaki ◽

Harald Renz

Keyword(s):

Molecular Diagnosis ◽

Allergen Immunotherapy

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Olive, grass or both? Molecular diagnosis for the allergen immunotherapy selection in polysensitized pollinic patients

Allergy ◽

10.1111/all.12474 ◽

2014 ◽

Vol 69 (10) ◽

pp. 1357-1363 ◽

Cited By ~ 32

Author(s):

C. Moreno ◽

J. L. Justicia ◽

J. Quiralte ◽

Á. Moreno-Ancillo ◽

A. Iglesias-Cadarso ◽

...

Keyword(s):

Molecular Diagnosis ◽

Allergen Immunotherapy

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ImmunoCAT study: study of the impact of molecular diagnosis by ImmunoCAP ISAC® 112 on allergen Immunotherapy prescription in CATalonia

World Allergy Organization Journal ◽

10.1016/j.waojou.2020.100143 ◽

2020 ◽

Vol 13 (8) ◽

pp. 100143

Author(s):

Teresa Garriga-Baraut ◽

Moisés Labrador-Horrillo ◽

Giovanna Araujo ◽

Miguel A. Baltasar-Dragó ◽

Maria Basagaña-Torrento ◽

...

Keyword(s):

Molecular Diagnosis ◽

Allergen Immunotherapy ◽

The Impact ◽

Immunocap Isac

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Molecular allergology and its impact in specific allergy diagnosis and therapy

10.22541/au.161778300.06888327/v1 ◽

2021 ◽

Author(s):

Domingo Barber Hernández ◽

Araceli Diaz Perales ◽

Maria Escribese ◽

Jörg Kleine-Tebbe ◽

Paolo Matricardi ◽

...

Keyword(s):

Clinical Practice ◽

Molecular Diagnosis ◽

Allergen Immunotherapy ◽

Daily Life ◽

Allergy Diagnosis ◽

In Vitro Diagnostics ◽

Progressive Development ◽

Molecular Allergology ◽

Underlying Mechanisms

Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy decisions. In parallel to the discovery of allergenic molecules, there was a progressive development of a regulation framework that affected both in vitro diagnostics and Allergen Immunotherapy products. With a progressive understanding of underlying mechanisms associated to Allergen immunotherapy and an increasing experience of application of molecular diagnosis in daily life, we focus in analyzing the evidences of the value provided by molecular allergology in daily clinical practice, with a focus on Allergen Immunotherapy decissions.

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