scholarly journals Új, epicutan módszer az allergia oki kezelésére

2017 ◽  
Vol 158 (23) ◽  
pp. 895-899
Author(s):  
László Endre
Keyword(s):  
Allergen Immunotherapy ◽  
Allergic Diseases ◽  
Bacterial Toxin ◽  
Recombinant Allergens ◽  
The Future ◽  
Causal Treatment ◽  
Recommended Therapy

Abstract: The only causal treatment for the allergic diseases is the allergen immunotherapy. Besides oral and injection forms, an epicutaneous form is known as well. During the immunization process the use of an adjuvant material is advisable besides the allergen. That adjuvant material can be (besides of the aluminium hydroxid and tyrosine) a bacterial toxin, too. In idealistic circumstances we can substitute the native allergen with its recombinant variant, which could keep its immunogenicity but had lost the allergenicity. In the future the recommended therapy could be the safe, painless, epicutaneous hyposensitization, with recombinant allergens, with bacterial toxin as adjuvants. Orv Hetil. 2017; 158(23): 895–899.

Recombinant Allergens – Production Methods and Use in Molecular Diagnosis and Allergen Immunotherapy

Alergologia ◽  
2020 ◽  
Vol 1 (4) ◽  
pp. 10
Author(s):  
Maria Roxana Buzan ◽  
Manuela Grijincu ◽  
Lauriana-Eunice Zbîrcea ◽  
Laura Haidar ◽  
Carmen Bunu-Panaitescu
Keyword(s):  
Molecular Diagnosis ◽  
Allergen Immunotherapy ◽  
Recombinant Allergens ◽  
Production Methods

Characteristics of Asian Mosquito Saliva Allergens for Specific Diagnoses and Effective Therapies

2020 ◽  
Vol 21 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Soung-Hoo Jeon
Keyword(s):  
Allergic Reaction ◽  
East Asia ◽  
East Asian ◽  
Diagnosis And Treatment ◽  
Recombinant Allergens ◽  
Systemic Reactions ◽  
The Future ◽  
Mosquito Saliva ◽  
The Difference ◽  
Future Direction

An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allergens. In particular, candidate allergens of mosquitoes that are well suited to the ecology of mosquitoes that occur mainly in East Asia will be identified and introduced. By doing so, the diagnosis and treatment of patients with severe sensitivity to mosquito allergy will be improved by predicting the characteristics of East Asian mosquito allergy, presenting the future direction of production of recombinant allergens, and understanding the difference between East and West.

scholarly journals Nanoparticulate Adjuvants and Delivery Systems for Allergen Immunotherapy

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Juliana De Souza Rebouças ◽  
Irene Esparza ◽  
Marta Ferrer ◽  
María Luisa Sanz ◽  
Juan Manuel Irache ◽  
...  
Keyword(s):  
Allergen Immunotherapy ◽  
Allergic Diseases ◽  
Delivery Systems ◽  
Efficacy And Safety ◽  
Significant Progress ◽  
Reduced Dose ◽  
Promising Strategy ◽  
Polymeric Carriers ◽  
Local Side

In the last decades, significant progress in research and clinics has been made to offer possible innovative therapeutics for the management of allergic diseases. However, current allergen immunotherapy shows limitations concerning the long-term efficacy and safety due to local side effects and risk of anaphylaxis. Thus, effective and safe vaccines with reduced dose of allergen have been developed using adjuvants. Nevertheless, the use of adjuvants still has several disadvantages, which limits its use in human vaccines. In this context, several novel adjuvants for allergen immunotherapy are currently being investigated and developed. Currently, nanoparticles-based allergen-delivery systems have received much interest as potential adjuvants for allergen immunotherapy. It has been demonstrated that the incorporation of allergens into a delivery system plays an important role in the efficacy of allergy vaccines. Several nanoparticles-based delivery systems have been described, including biodegradable and nondegradable polymeric carriers. Therefore, this paper provides an overview of the current adjuvants used for allergen immunotherapy. Furthermore, nanoparticles-based allergen-delivery systems are focused as a novel and promising strategy for allergy vaccines.

scholarly journals Impact of Tree Pollen Distribution on Allergic Diseases in Serbia: Evidence of Implementation of Allergen Immunotherapy to Betula verrucosa

Medicina ◽  
2020 ◽  
Vol 56 (2) ◽  
pp. 59 ◽  
Author(s):  
Rajna Minić ◽  
Mirjana Josipović ◽  
Vesna Tomić Spirić ◽  
Marija Gavrović-Jankulović ◽  
Aleksandra Perić Popadić ◽  
...  
Keyword(s):  
Allergen Immunotherapy ◽  
Practical Importance ◽  
Allergic Diseases ◽  
Pollen Concentration ◽  
Tree Pollen ◽  
Starting Point ◽  
Pollen Species ◽  
Allergenic Plants ◽  
Betula Verrucosa ◽  
The Relationship

Background and objectives: The relationship between air pollen quantity and the sensitization of allergic patients is crucial for both the diagnosis and treatment of allergic diseases. Weather conditions influence the distribution of allergenic pollen and increases in pollen concentration may negatively affect the health of allergic patients. The aim of this study was to analyze the implementation of allergen immunotherapy with regard to air pollen concentration. Material and Methods: Here we examined the relationship between Betula air pollen concentration and the usage of Betula verrucosa allergen immunotherapy in Serbia. Examination covered the period from 2015 to 2018. Measurement of airborne pollen concentration was performed with Lanzoni volumetric pollen traps. The evidence of the usage of sublingual allergen immunotherapy (SLIT) was gathered from patients with documented sensitization to specific pollen. Results: During this period tree pollens were represented with 58% ± 21% of all measured air pollen species, while Betula pollen represented 15% ± 8% of all tree pollens. Betula pollination peaked in April. Allergen immunotherapy to Betula verrucosa in Serbia is entirely conducted as sublingual immunotherapy and represents 47.1% ± 1.4% of issued tree pollen SLIT. The use of pollen SLIT increased by 68% from 2015 to 2018, with an even greater increase in usage recorded for Betula SLIT—80%. Conclusions: This analysis shows a clear causative relationship between pollination and the type/prevalence of applied allergen immunotherapy. Information about the flowering seasons of allergenic plants is very important for people who suffer from allergy, for clinical allergologists, as well as for governing authorities. The presented data is of practical importance to the proper timing of immunotherapy initiation and of importance for urban landscaping. The obtained data can be the starting point for the instatement of a thorough epidemiological study and the inclusion of Serbia on the pollen map of Europe.

Recombinant allergens: What does the future hold?

2011 ◽  
Vol 127 (4) ◽  
pp. 860-864 ◽  
Author(s):  
Rudolf Valenta ◽  
Katarzyna Niespodziana ◽  
Margit Focke-Tejkl ◽  
Katharina Marth ◽  
Hans Huber ◽  
...  
Keyword(s):  
Recombinant Allergens ◽  
The Future

scholarly journals COVID-19-vaccination in patients receiving allergen immunotherapy (AIT) or biologics - EAACI recommendations

2021 ◽  
Author(s):  
Marek Jutel ◽  
María José Torres ◽  
Oscar Palomares ◽  
Cezmi Akdis ◽  
Thomas Eiwegger ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Modulation ◽  
Allergen Immunotherapy ◽  
Expert Panel ◽  
Allergic Diseases ◽  
Treatment Modalities ◽  
European Academy ◽  
Type 3

Immune modulation is a key therapeutic tool for allergic diseases and asthma. It can be achieved in an antigen-specific way via allergen immunotherapy (AIT) or in endotype-driven approach using biologicals that target the major pathways of the type 2 (T2) immune response: IgE, IL-5 and IL-4/IL-13. COVID-19 vaccine provides an excellent opportunity to tackle the global pandemics and is currently being applied in an accelerated rhythm worldwide. It works as well through immune modulation. Thus, as there is an obvious interference between these treatment modalities recommendations on how they should be applied in sequence are expected. The European Academy of Allergy and Clinical Immunology (EAACI) gathered an outstanding expert panel under its Research and Outreach Committee (ROC). This expert panel was called to evaluate the evidence and formulate recommendation on the administration of COVID-19 vaccine in patients with allergic diseases and asthma receiving AIT or biologicals. The panel also formulated recommendations for COVID-19 vaccine in association with biologicals targeting the type 1 or type 3 immune response. In formulating recommendations, the panel evaluated the mechanisms of COVID-19 infection, of COVID-19 vaccine, of AIT and of biologicals and considered the data published for other anti-infectious vaccines administered concurrently with AIT or biologicals.

Sign in / Sign up

Export Citation Format

Share Document