Synthesis and Characterization of Novel Atypical Sphingoid Bases

10.26434/chemrxiv.12094041.v1 ◽

2020 ◽

Author(s):

Essa M. Saied ◽

Christoph Arenz

Keyword(s):

Analytical Data ◽

Synthesis And Characterization ◽

Sphingoid Bases ◽

Pathological Conditions

The synthesis of atypical sphingoid bases is described. The compounds described here have been postulated from biochemical investigations for pathological conditions or certain tissues. Most of the compounds here have been confirmed. Full synthetic and analytical data is provided. <br>

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Synthesis and Characterization of Cu(I) Complex Compounds With Methyl Isonicotinate

Canadian Journal of Chemistry ◽

10.1139/v75-376 ◽

1975 ◽

Vol 53 (17) ◽

pp. 2657-2663 ◽

Cited By ~ 13

Author(s):

Mohamed A. S. Goher

Keyword(s):

Charge Transfer ◽

Analytical Data ◽

Complex Compounds ◽

Synthesis And Characterization ◽

Conductivity Measurements ◽

Visible Spectra

The preparation of Cu(I) complexes of methyl isonicotinate, MeIN, of the formula (MeIN)nCuX, in which n = 1,2, 3, and 4 and X is Cl, Br, I, CN, SCN, and ClO4, has been described. The isolated complexes are characterized by their analytical data, diamagnetism, and conductivity measurements. The M → L charge transfer bands in the visible spectra and the i.r. spectra of these complexes are discussed.

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Synthesis and Characterization of Cu(II) and Mono-and Dinuclear Pb(II) Complexes Derived from 3,5-Diacetyl-1,2,4-triazole

Zeitschrift für Naturforschung B ◽

10.1515/znb-1994-0517 ◽

1994 ◽

Vol 49 (5) ◽

pp. 665-671 ◽

Cited By ~ 8

Author(s):

P. Souza ◽

A. I. Matesanz ◽

A. Arquero ◽

V. Fernandez

Keyword(s):

Mass Spectra ◽

Analytical Data ◽

Synthesis And Characterization ◽

Dinuclear Complexes ◽

Direct Reaction ◽

Analogous Reaction ◽

Metal Free ◽

H Nmr

Template 1:1 condensation of 3,5-diacetyl-1,2,4-triazole with thiocarbohydrazide or car- bohydrazide in the presence of 1 equivalent of Pb(SCN)2 produces mononuclear [2 + 1] complexes 1 and 3. The analogous reaction with thiosemicarbazide and semicarbazide produces the dinuclear [1+2] complex 2 and the mononuclear metal free 4. The carbohydrazide derivative 3 reacts with the carbohydrazide or the 1,3-diaminopropane to yield the macrocyclic dinuclear complexes 5 and 6. Direct reaction of 3,5-diacetyl-1,2,4-triazole with thiocarbohydrazide. carbohydrazide, thiosemicarbazide and semicarbazide leads to open [1+1] ligands L1, L2, L3, L4, and closed [1+1] ligands (mesocyclic ligands) L5 and L6 were prepared by addition of 1 equivalent of LiOH to the reaction mixture. The reaction of open and mesocyclic [1+1] ligands with copper(II) salts gives [CuLX2] and [Cu2+L2-] complexes. All these compounds have been characterized by 1H NMR, IR, electronic and mass spectra and by analytical data.

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Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx

International Journal of Molecular Sciences ◽

10.3390/ijms22158171 ◽

2021 ◽

Vol 22 (15) ◽

pp. 8171

Author(s):

Essa M. Saied ◽

Christoph Arenz

Keyword(s):

Plasma Membranes ◽

Stereoselective Synthesis ◽

Chemical Characterization ◽

Great Promise ◽

Sphingoid Bases ◽

Animal Physiology ◽

Pathological Conditions ◽

Low Concentrations ◽

Derivatives Of

Sphingolipids are ubiquitous in eukaryotic plasma membranes and play major roles in human and animal physiology and disease. This class of lipids is usually defined as being derivatives of sphingosine, a long-chain 1,3-dihydroxy-2-amino alcohol. Various pathological conditions such as diabetes or neuropathy have been associated with changes in the sphingolipidome and an increased biosynthesis of structurally altered non-canonical sphingolipid derivatives. These unusual or non-canonical sphingolipids hold great promise as potential diagnostic markers. However, due to their low concentrations and the unavailability of suitable standards, the research to explore the secret of this class of ‘Sphinx’ lipids is ultimately hampered. Therefore, the development of efficient and facile syntheses of standard compounds is a key endeavor. Here, we present various chemical approaches for stereoselective synthesis and in-depth chemical characterization of a set of novel sphingoid bases which were recently utilized as valuable tools to explore the metabolism and biophysical properties of sphingolipids, but also to develop efficient analytical methods for their detection and quantification.

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Synthesis and Characterization of New Kinds Sulfoxide Extractants for Palladium(II)

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.287-290.1841 ◽

2011 ◽

Vol 287-290 ◽

pp. 1841-1846

Author(s):

Li Li Chen ◽

Zu Min Qiu ◽

Zhen Zhong Huang ◽

Yan Fen Wu

Keyword(s):

Oxygen Atom ◽

Ir Spectra ◽

Coordination Number ◽

Elemental Analysis ◽

Ethyl Ether ◽

Analytical Data ◽

Synthesis And Characterization ◽

Ft Ir ◽

Extraction Parameters

Three new extractants for palladium(II) extraction: bis(noctyl-Sulfinyl-ethyl) ether(L1), bis(isooctyl-Sulfinyl-ethyl)ether(L2), bis(isooctyl-Sulfinyl-ethoxy)ethane(L3) were synthesized. Micro-analytical data, elemental analysis, 1HNMR and IR-spectra were used to confirm the structures. Based on independent extraction experiments of Pd(II) , the extraction parameters of Pd(II) were studied in detail, and the optimal extraction parameters were obtained and summarized as the following: H+ concentration of aqueous phase 1.0-1.5 mo1·L-1, sulfoxide extractants concentration 0.01-0.1 mo1·L-1. The order of the extractability of the three extractants towards palladium(II) was L2>L3>L1. The coordination number was studied by the slope method. The results indicated that, in low acidity, the coordination number for extracting palladium (II) was 1.0 with all three extractants, while it was 2.0 in high acidity. FT-IR spectra was used to analyze the structure of the complex. Palladium (II) was coordinated with the oxygen atom in S=O group of the three extractants. and palladium (II) may also coordinated with the oxygen atom in C-O-C group of extractant L1, L2.

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