scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

scholarly journals Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics

2019 ◽  
Vol 55 (27) ◽  
pp. 3868-3871 ◽  
Author(s):  
Barbara E. Souza ◽  
Svemir Rudić ◽  
Kirill Titov ◽  
Arun S. Babal ◽  
James D. Taylor ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Inelastic Neutron Scattering ◽  
Metal Organic Framework ◽  
Inelastic Neutron ◽  
Cancer Drug ◽  
Host Interactions ◽  
Composite Systems ◽  
Anti Cancer ◽  
Metal Organic ◽  
Organic Framework

Guest–host interactions of mechanochemically synthesized drug@MOF composite systems revealed by inelastic neutron scattering.

scholarly journals Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

CrystEngComm ◽  
2020 ◽  
Vol 22 (27) ◽  
pp. 4526-4530
Author(s):  
Barbara E. Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Delivery Systems ◽  
Low Cost ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
Drug Molecules ◽  
Anti Cancer ◽  
Metal Organic ◽  
Host Metal ◽  
Organic Framework

Low-cost mechanochemistry methods for in situ confinement of “guest” drug molecules into a “host” metal–organic framework to yield nanoscale guest@host drug delivery systems.

Targeted VEGF-triggered release of an anti-cancer drug from aptamer-functionalized metal–organic framework nanoparticles

Nanoscale ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 4650-4657 ◽  
Author(s):  
Wei-Hai Chen ◽  
Sohn Yang Sung ◽  
Michael Fadeev ◽  
Alessandro Cecconello ◽  
Rachel Nechushtai ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Cancer Drug ◽  
Triggered Release ◽  
Anti Cancer ◽  
Metal Organic ◽  
Targeted Release ◽  
Organic Framework

Drug-loaded DNA-capped metal–organic framework nanoparticles are unlocked by the VEGF biomarker, resulting in the targeted release of the drug.

Halogen Functionalization of Aluminium Fumarate Metal–Organic Framework via In Situ Hydrochlorination of Acetylenedicarboxylic Acid

2019 ◽  
Vol 72 (10) ◽  
pp. 835 ◽  
Author(s):  
Tobie J. Matemb Ma Ntep ◽  
Wei Wu ◽  
Hergen Breitzke ◽  
Carsten Schlüsener ◽  
Bastian Moll ◽  
...  
Keyword(s):  
Selective Adsorption ◽  
Metal Organic Framework ◽  
Fold Increase ◽  
Aluminium Chloride ◽  
One Pot ◽  
Metal Organic ◽  
Acetylenedicarboxylic Acid ◽  
Adsorption Of Co2 ◽  
Organic Framework

The successful chloro-functionalization of aluminium fumarate (MIL-53-Fum) was achieved by in situ hydrochlorination of acetylenedicarboxylic acid on reaction with aluminium chloride resulting in the formation of the aluminium chlorofumarate metal–organic framework (MIL-53-Fum-Cl=[Al(OH)(Fum-Cl)]) in a one-pot reaction. The chloro functional groups decorating the pores enhance gas (CO2, CH4, and H2) sorption capacities and affinity compared with the non-functionalized MIL-53-Fum. The functionalization also results in a 2-fold increase in the selective adsorption of CO2 over CH4 compared with MIL-53-Fum.

scholarly journals Elucidating the Drug Release from Metal–Organic Framework Nanocomposites via In Situ Synchrotron Microspectroscopy and Theoretical Modeling

2020 ◽  
Vol 12 (4) ◽  
pp. 5147-5156 ◽  
Author(s):  
Barbara E. Souza ◽  
Lorenzo Donà ◽  
Kirill Titov ◽  
Paolo Bruzzese ◽  
Zhixin Zeng ◽  
...  
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Theoretical Modeling ◽  
Metal Organic ◽  
Organic Framework

scholarly journals One-pot coating of LiCoPO4/C by a UiO-66 metal–organic framework

RSC Advances ◽  
2020 ◽  
Vol 10 (58) ◽  
pp. 35206-35213
Author(s):  
Abdelaziz M. Aboraia ◽  
Viktor V. Shapovalov ◽  
Alexnader A. Guda ◽  
Vera V. Butova ◽  
Alexander Soldatov
Keyword(s):  
Cathode Material ◽  
Electrochemical Properties ◽  
High Voltage ◽  
Metal Organic Framework ◽  
One Pot ◽  
Metal Organic ◽  
Organic Framework

LiCoPO4 (LCP) is a promising high voltage cathode material but suffers from low conductivity and poor electrochemical properties.

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