Targeted VEGF-triggered release of an anti-cancer drug from aptamer-functionalized metal–organic framework nanoparticles

Nanoscale ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 4650-4657 ◽  
Author(s):  
Wei-Hai Chen ◽  
Sohn Yang Sung ◽  
Michael Fadeev ◽  
Alessandro Cecconello ◽  
Rachel Nechushtai ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Cancer Drug ◽  
Triggered Release ◽  
Anti Cancer ◽  
Metal Organic ◽  
Targeted Release ◽  
Organic Framework

Drug-loaded DNA-capped metal–organic framework nanoparticles are unlocked by the VEGF biomarker, resulting in the targeted release of the drug.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

scholarly journals Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics

2019 ◽  
Vol 55 (27) ◽  
pp. 3868-3871 ◽  
Author(s):  
Barbara E. Souza ◽  
Svemir Rudić ◽  
Kirill Titov ◽  
Arun S. Babal ◽  
James D. Taylor ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Inelastic Neutron Scattering ◽  
Metal Organic Framework ◽  
Inelastic Neutron ◽  
Cancer Drug ◽  
Host Interactions ◽  
Composite Systems ◽  
Anti Cancer ◽  
Metal Organic ◽  
Organic Framework

Guest–host interactions of mechanochemically synthesized drug@MOF composite systems revealed by inelastic neutron scattering.

scholarly journals Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

CrystEngComm ◽  
2020 ◽  
Vol 22 (27) ◽  
pp. 4526-4530
Author(s):  
Barbara E. Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Delivery Systems ◽  
Low Cost ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
Drug Molecules ◽  
Anti Cancer ◽  
Metal Organic ◽  
Host Metal ◽  
Organic Framework

Low-cost mechanochemistry methods for in situ confinement of “guest” drug molecules into a “host” metal–organic framework to yield nanoscale guest@host drug delivery systems.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle

2018 ◽  
Vol 54 (55) ◽  
pp. 7617-7620 ◽  
Author(s):  
Kristina Roth Stefaniak ◽  
Charity C. Epley ◽  
Joshua J. Novak ◽  
Margaret L. McAndrew ◽  
Hannah D. Cornell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Small Molecules ◽  
Metal Organic Framework ◽  
Delivery Vehicle ◽  
Triggered Release ◽  
Drug Delivery Vehicle ◽  
Metal Organic ◽  
Organic Framework

A nano metal–organic-framework (nanoMOF) was employed as a first-of-its kind drug delivery vehicle (DDV) for the photo-controlled release of therapeutics with simultaneous breakdown of the carrier into small molecules.

Size and surface controllable metal–organic frameworks (MOFs) for fluorescence imaging and cancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (13) ◽  
pp. 6205-6211 ◽  
Author(s):  
Xuechuan Gao ◽  
Ruixue Cui ◽  
Guanfeng Ji ◽  
Zhiliang Liu
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Anti Cancer ◽  
Metal Organic ◽  
Organic Framework

This work presents a novel size and surface controllable metal–organic framework, UIO-66-NH2-FA-5-FAM/5-FU, which possesses the superior characteristics of targeted identification of cancer cells, bioimaging and obvious anti-cancer effects in vivo.

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